A5059748298- Dietary Effects on Health
- Exercise and Physiological Responses
- Infant Nutrition and Health
- Asthma and respiratory diseases
- Diet and metabolism studies
- Eosinophilic Esophagitis
- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Microbial Metabolites in Food Biotechnology
- Behavioral Health and Interventions
- COVID-19 and Mental Health
- Mycotoxins in Agriculture and Food
- Diet, Metabolism, and Disease
- Smoking Behavior and Cessation
- Diabetic Foot Ulcer Assessment and Management
- Studies on Chitinases and Chitosanases
- Immunotoxicology and immune responses
- IL-33, ST2, and ILC Pathways
- Biomedical Research and Pathophysiology
- Tryptophan and brain disorders
- Occupational exposure and asthma
- Pressure Ulcer Prevention and Management
- Air Quality and Health Impacts
- Education and Learning Interventions
- Freezing and Crystallization Processes
Utrecht University
2012-2024
Cow’s milk allergy is a common food among infants. Improved hygiene conditions and loss of microbial diversity are associated with increased risk development. The intestinal immune system essential for oral tolerance induction. In this respect, bacterial CpG DNA known to drive Th1 regulatory T-cell (Treg) development via Toll-Like-Receptor 9 (TLR-9) signaling, skewing away from the allergic Th2 phenotype. We aimed induce allergen specific delivery poly (lactic-co-glycolic acid) nanoparticles...
The aim of this cross-sectional study was to investigate the association between a healthier diet, perceived immune fitness, and biomarkers system. N = 108 participants (31 men 77 women), 18–30 years old, completed questionnaire, comprising Healthy Diet Scale (HDS) 1-item scale assessing fitness. In addition, saliva samples were collected C-reactive protein (CRP) cytokine concentrations interleukin (IL)− 1β IL-8 determined. Overall, significant correlation found HDS score fitness (r 0.221, p...
Background: Dietary non-digestible galacto-oligosaccharides (GOS) suppress allergic responses in mice sensitized and challenged with house dust mite (HDM). Budesonide is the standard therapy for asthma humans but not always completely effective. Aim: To compare efficacy of budesonide or different doses GOS alone a combination on HDM-allergic mice. Methods: BALB/c were HDM, while fed control diet supplemented 1 2.5 w/w% GOS, either oropharyngeally instilled budesonide. Systemic local...
Two to four percentage of infants are affected by cow's milk allergy (CMA), which persists in 20% cases. Intervention approaches using early oral exposure protein or hydrolysed formula being studied for CMA prevention. Yet, concerns regarding safety and/or efficacy remain be tackled particular high-risk non-exclusively breastfed infants. Therefore, safe and effective strategies improve life tolerance induction may considered.We aim investigate the prevention pre-exposure two selected 18-AA...
Deoxynivalenol (DON), a highly prevalent contaminant of grain-based products, is known to induce reproductive- and immunotoxicities. Considering the importance immune development in early life, present study investigated effects perinatal DON exposure on allergy vaccine responsiveness offspring. Pregnant mice received control or DON-contaminated diets (12.5 mg/kg diet) during pregnancy lactation. After weaning, female offspring were sensitized ovalbumin (OVA) by oral administration OVA with...
Background Pregnancy is a portentous stage in life, during which countless events are precisely orchestrated to ensure healthy offspring. Maternal microbial communities thought have profound impact on development. Although antibiotic drugs may interfere these processes, they constitute the most frequently prescribed medication pregnancy prohibit detrimental consequences of infections. Gestational intervention linked preeclampsia and negative effects neonatal immunity. Even though...
Cow's milk allergy is a common food in infants, and associated with an increased risk of developing other allergic diseases. Dietary selenium (Se), one the essential micronutrients for humans animals, important bioelement which can influence both innate adaptive immune responses. However, effects Se on are still largely unknown. In current study it was investigated whether dietary supplementation inhibit whey-induced animal research model. Three-week-old female C3H/HeOuJ mice were...
Deoxynivalenol (DON), a highly prevalent food contaminant, is known to induce reproductive and immunotoxicity in humans upon exposure. The present study focused on the consequences of exposure DON during pregnancy for placental barrier immune function, as well fetal survival. Female mice received diets contaminated with (6.25 12.5 mg/kg diet), starting immediately after mating until end experiment. On day 17 animals were killed, maternal samples collected further analysis. Feeding...
Early-life nutrition significantly impacts vaccination efficacy in infants, whose immune response to vaccines is weaker compared adults. This study investigated female C57Bl/6JOlaHsd mice (6 weeks old) fed diets with 0.7% galacto-oligosaccharides (GOS)/long-chain fructo-oligosaccharides (lcFOS) (9:1), 0.3% human milk oligosaccharides (HMOS), or a combination (GFH) for 14 days prior and during vaccination. Delayed-type hypersensitivity (DTH) was measured by assessing ear swelling following an...
Survey research found poorer baseline immune fitness for self-reported hangover-sensitive drinkers compared to hangover-resistant drinkers. However, up now a limited number of clinical studies revealed mixed results regarding the relationship between concentrations biomarkers systemic inflammation in blood or saliva with hangover severity, and could not differentiate The aim this study was assess at multiple timepoints following an alcohol day alcohol-free control day.The had...
It is vital that Immune fitness, i.e., how well the immune system functions and reacts to challenges, can be reliably examined. The current study aimed compare fitness with assessments of saliva biomarkers systemic inflammation.N = 108 healthy young adults (18-30-year-old students Utrecht University, Netherlands) participated in study. A sample was collected for biomarker assessment (Interleukin (IL)-1β, IL-6, IL-8, IL-10, immunoglobulin (IgA), tumor necrosis factor-alpha (TNF-α), c-reactive...
Abstract Exercise is generally beneficial for health but strenuous exercise can have detrimental effects on the gastrointestinal tract. The combination of ischemia and heat shock during a crucial contributor to intestinal epithelial damage. Growing evidence points towards an important regulatory role gut microbes in homeostasis. Here, we characterize compare moderate vigorous training damage, stress response, inflammatory microbiota alterations mice investigate mechanisms underlying...
Exercise is generally beneficial for health but strenuous exercise can have detrimental effects on the gastrointestinal tract. The combination of ischemia and heat shock during a crucial contributor to intestinal epithelial damage. Growing evidence points towards an important regulatory role gut microbes in homeostasis. Here, we characterize compare moderate vigorous training damage, stress response, inflammatory microbiota alterations mice investigate mechanisms underlying exercise-induced...
Exercise is generally beneficial for health but strenuous exercise can have detrimental effects on the gastrointestinal tract. The combination of ischemia and heat shock during a crucial contributor to intestinal epithelial damage. Growing evidence points towards an important regulatory role gut microbes in homeostasis. Here, we characterize compare moderate vigorous training damage, stress response, inflammatory microbiota alterations mice investigate mechanisms underlying exercise-induced...
Abstract Nephropathic cystinosis is a rare monogenetic kidney disease caused by mutations in the lysosomal transporter cystinosin (encoded CTNS ) that, to date, has no cure. The hallmark of this accumulation cystine and decline proximal tubular function leading failure early life. In project, we developed novel gene repair strategy using CRISPR/Cas9 Homology-Independent Targeted Integration (HITI) restore . A novel, non-viral peptide-mediated approach was used deliver Cas9-guideRNA...