A5089557681- Reproductive System and Pregnancy
- Hepatitis B Virus Studies
- SARS-CoV-2 and COVID-19 Research
- Pregnancy and Medication Impact
- Hepatitis C virus research
- Immunotherapy and Immune Responses
- COVID-19 Clinical Research Studies
- Immune Cell Function and Interaction
- Endometriosis Research and Treatment
- Liver Disease Diagnosis and Treatment
- Pregnancy and preeclampsia studies
- Dermatology and Skin Diseases
- Skin Protection and Aging
- Blood groups and transfusion
- T-cell and B-cell Immunology
- Complement system in diseases
- Preterm Birth and Chorioamnionitis
- COVID-19 Impact on Reproduction
- Long-Term Effects of COVID-19
- Renal Diseases and Glomerulopathies
- Immunodeficiency and Autoimmune Disorders
- Food Allergy and Anaphylaxis Research
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Vaccine Coverage and Hesitancy
Radboud University Nijmegen
2016-2025
Radboud University Medical Center
2016-2025
University Medical Center
2014-2025
Radboud Institute for Molecular Life Sciences
2019-2024
Erasmus University Rotterdam
2004-2012
Erasmus MC
2003-2008
Reinier de Graaf Hospital
2008
GTx (United States)
2004
Academic Medical Center
2004
Leiden University Medical Center
1998-2002
Chronic hepatitis B virus (HBV) infection is characterized by a weak immune response to HBV. Regulatory T cells (Treg) can suppress the function of effector and may thus be key players in this impaired response. Changes functionality or number Treg could explain decreased antiviral chronic HBV patients. To investigate role infection, we compared proportional frequency peripheral blood 50 patients, 23 healthy controls, 9 individuals with resolved infection. A higher percentage Treg, defined...
Effective immunity requires a complex network of cellular and humoral components that interact with each other are influenced by different environmental host factors. We used systems biology approach to comprehensively assess the impact genetic factors on immune cell populations in peripheral blood, including associations immunoglobulin concentrations, from ∼500 healthy volunteers Human Functional Genomics Project. Genetic heritability estimation showed variations T numbers more strongly...
Dendritic cells (DC) play an important role in the induction of T-cell responses. We hypothesize that hampered antiviral response chronic hepatitis B patients is a result impaired dendritic cell function. In this study, we compared number, phenotype and functionality two blood precursor DC, myeloid DC (mDC) plasmacytoid (pDC), with healthy volunteers. No differences percentages mDC pDC peripheral mononuclear were observed between controls. The allostimulatory capacity isolated vitro matured...
Chronic hepatitis B virus (HBV) infection is the result of an inadequate immune response towards virus. Myeloid dendritic cells (mDC) patients with chronic HBV are impaired in their maturation and function, resulting more tolerogenic rather than immunogenic responses, which may contribute to viral persistence. The mechanism responsible for altered mDC function remains unclear. HBV-infected display large amounts particles proteins circulation, especially surface antigen HBsAg, allows multiple...
Is menstrual blood a suitable source of endometrial derived lymphocytes?Mononuclear cells isolated from samples (menstrual mononuclear (MMC)) are clearly distinct peripheral (PBMC) and show strong resemblance with biopsy-derived cells.A critical event in the onset pregnancy is implantation embryo uterine wall. The immune cell composition endometrium at time considered pivotal for success. Despite advancing knowledge on population uterus, role reproductive disorders still not fully resolved,...
The immune response to COVID-19 vaccination is inferior in kidney transplant recipients (KTRs) and a lesser extent patients on dialysis or with chronic disease (CKD). We assessed the 6 months after mRNA-1273 compared this controls.
Natural killer (NK) cells, with a unique NK cell receptor phenotype, are abundantly present in the non-pregnant (endometrium) and pregnant (decidua) humanuterine mucosa. It is hypothesized that cells endometrium precursors for decidual during pregnancy. Microenvironmental changes can alter phenotype of but it unclear whether their repertoire under influence To examine reveal phenotypic modifications upon pregnancy, we immunophenotyped both endometrial early-pregnancy using flow cytometry. We...
The role of complement in the atypical form hemolytic uremic syndrome (aHUS) has been investigated extensively recent years. As HUS-associated bacteria Shiga-toxin-producing Escherichia coli (STEC) can evade system, we hypothesized that dysregulation is also important infection-induced HUS. Serological profiles (C3, FH, FI, AP activity, C3d, C3bBbP, C3b/c, TCC, αFH) and genetic (CFH, CFI, CD46, CFB, C3) alternative pathway were prospectively determined acute convalescent phase disease...
Abstract Pregnancy requires a delicate immune balance that nurtures the allogeneic fetus, while maintaining reactivity against pathogens. Despite increasing knowledge, data is lacking on transition of pre-pregnancy endometrial lymphocytes to pregnancy state. Here, we immunophenotyped from endometrium (MMC), term decidua parietalis (DPMC), and PBMC for direct comparison. We found cell composition MMC DPMC clearly differ each other, with less NK-cells, more NKT-cells T-cells in DPMC. An...
Abstract Background COVID-19 is associated with increased morbidity and mortality in patients chronic kidney disease (CKD) stages G4-G5, on dialysis or after transplantation (kidney replacement therapy, KRT). SARS-CoV-2 vaccine trials do not elucidate if vaccination effective these patients. Vaccination against other viruses known to be less Our objective assess the efficacy safety of various types vaccinations CKD G4-G5 KRT. Methods In this national prospective observational cohort study we...
Mesenchymal stem cells (MSCs) have demonstrated promising therapeutic potential across a wide range of diseases including (multi) organ injury in neonates. Despite the reported preclinical successes MSC therapy, major challenge their clinical translation is limited understanding biodistribution after administration. This knowledge gap needs to be addressed allow implementation. Accordingly, this study, we propose that silica-coated gold nanoparticles (AuMS) are tool for vivo tracing. study...
Background Drug survival of biologics for psoriasis has reported to be lower in females than males first-generation (TNF-α/interleukin (IL) 12/23 inhibitors (i)); insights newer (IL17i and IL23i) are scarce. Objectives To study sex-differences drug other treatment outcomes (including IL17i/IL23i) patients with psoriasis. Methods Data were obtained from the Dutch, prospective, multicenter, BioCAPTURE registry. Kaplan-Meier curves split specific discontinuation reasons stratified sex. Cox...