A5052838073- Thyroid Cancer Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- Thyroid Disorders and Treatments
- Cardiovascular Function and Risk Factors
- Growth Hormone and Insulin-like Growth Factors
- Cardiovascular Disease and Adiposity
- Cardiac Imaging and Diagnostics
- Adrenal and Paraganglionic Tumors
- Diet and metabolism studies
- Neuroendocrine Tumor Research Advances
- Adrenal Hormones and Disorders
- Liver Disease Diagnosis and Treatment
- Cardiovascular Health and Disease Prevention
- Thyroid and Parathyroid Surgery
- Advanced MRI Techniques and Applications
- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Immune Cell Function and Interaction
- Cancer, Hypoxia, and Metabolism
- Platelet Disorders and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Lipoproteins and Cardiovascular Health
- Diabetes Treatment and Management
- Parasites and Host Interactions
Radboud University Nijmegen
2015-2024
Radboud University Medical Center
2014-2024
University Medical Center
2002-2022
Leiden University Medical Center
2011-2021
Radboud Institute for Molecular Life Sciences
2016-2021
Geneeskundige en Gezondheidsdienst
2015-2020
University of Indonesia
2018
Vrije Universiteit Amsterdam
1974-2015
Leiden University
2004-2014
University Hospital and Clinics
2014
Journal Article European consensus for the management of patients with differentiated thyroid carcinoma follicular epithelium Get access Furio Pacini, Pacini Section Endocrinology and Metabolism, University Siena, Via Bracci, 53100 Italy (Correspondence should be addressed to F Pacini; Email: pacini8@unisi.it) Search other works by this author on: Oxford Academic Google Scholar Martin Schlumberger, Schlumberger Service de Médicine Nucléaire, Institut Gustave Roussy, Villejuif, France Henning...
The use of levothyroxine to treat subclinical hypothyroidism is controversial. We aimed determine whether provided clinical benefits in older persons with this condition.
The storage of triglyceride (TG) droplets in nonadipose tissues is called ectopic fat storage. Ectopic associated with insulin resistance and type 2 diabetes mellitus (T2DM). Not the triglycerides per se but accumulation intermediates lipid metabolism organs, such as liver, skeletal muscle, heart seem to disrupt metabolic processes impair organ function. We describe mechanisms depositions around consequences for each organs In addition, we systematically reviewed literature effects...
Abdominal obesity is a well-established risk factor for the development of type 2 diabetes. However, sex differences may exist. We aimed to investigate associations abdominal subcutaneous adipose tissue (SAT) and visceral (VAT) with insulin resistance secretion in men women.In this cross-sectional analysis Netherlands Epidemiology Obesity study, fasting postprandial concentrations glucose were measured fat depots assessed using magnetic resonance imaging 2253 participants (53% women). With...
Modern use of post-operative radioactive iodine (RAI) treatment for differentiated thyroid cancer (DTC) should be implemented in line with patients' risk stratification. Although beneficial effects radioiodine are undisputed high-risk patients, controversy remains intermediate-risk and some low-risk patients. Since the last consensus on post-surgical RAI DTC new retrospective data results prospective randomized trials have been published, which allowed development a European Thyroid...
Type 2 diabetes is associated with accelerated atherosclerosis. Because cell-derived microparticles support coagulation and inflammation, they may be involved in atherogenesis. We characterized circulating both patients uncomplicated, well-regulated type healthy subjects, as well their relationship metabolic control.Microparticles were isolated from plasma, stained annexin V, cell-specific monoclonal antibodies (MoAbs) a MoAb directed against tissue factor (TF), analyzed by flow cytometry....
Survival studies in differentiated thyroid carcinoma (DTC) may be biased because they have been performed heterogeneous populations. In addition, specific death causes DTC not documented well the literature.The aim of our study was to investigate survival and a homogeneous cohort patients.Patients included 366 consecutive patients with who had all treated according same protocol for initial therapy follow-up.Prognostic factors DTC-related were analyzed by univariate Cox regression analysis,...
To evaluate the long-term impact of cured Cushing's disease on subjective well-being, we assessed quality life by validated health-related questionnaires in 58 patients from transsphenoidal surgery (n = 58), some whom received additional radiotherapy 11) and/or bilateral adrenalectomy 3). The mean duration remission was 13.4 +/- 6.7 yr (range 2-25 yr). Patient data were compared with a control group 98 healthy subjects same age and sex distribution age-adjusted reference values available...
The long-term impact of acromegaly on subjective well-being after treatment GH excess is unclear. Therefore, we evaluated quality life by validated questionnaires in a cross-sectional study 118 successfully treated acromegalic patients. initial was transsphenoidal surgery most patients (92%), if necessary followed radiotherapy or octreotide. All were remission at the time assessment (GH, <1.9 mug/liter; normal IGF-I for age). General perceived reduced compared with controls all subscales (P...
Treatment options for patients with radioactive iodine (RaI) refractory metastases of differentiated thyroid carcinoma (DTC) are limited. We studied the effects multitarget tyrosine kinase inhibitor sorafenib on reinduction RaI uptake and tumor progression.Open, single center, arm 26-week prospective phase II study open-ended extension.We treated 31 progressive metastatic or locally advanced DTC 400 mg b.i.d. The primary endpoint was at 26 weeks. Additional endpoints were radiological...
Cardiac disease is the leading cause of mortality in type 2 diabetes mellitus (T2DM). Pioglitazone has been associated with improved cardiac outcome but also an elevated risk heart failure. We determined effects pioglitazone on myocardial function relation to high-energy phosphate, glucose, and fatty acid metabolism triglyceride content T2DM patients.Seventy-eight men without structural or inducible ischemia as assessed by dobutamine stress echocardiography were assigned (30 mg/d) metformin...
Transsphenoidal surgery is the treatment of choice for nonfunctioning pituitary macroadenomas (NFMA). In this study we evaluated long-term effects a strategy in which postoperative radiotherapy was not routinely applied to patients with NFMA.This retrospective follow-up study.We included 109 consecutive (age 56 +/- 13 yr) operated NFMA between 1992 and 2004.Radiological imaging revealed macroadenoma all patients, suprasellar extension 96% parasellar/infrasellar 36% cases. Visual field...