A5101566733- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Neuroendocrine Tumor Research Advances
- IgG4-Related and Inflammatory Diseases
- Fibroblast Growth Factor Research
- Peptidase Inhibition and Analysis
- Cancer Genomics and Diagnostics
- Phagocytosis and Immune Regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Crystallization and Solubility Studies
- Artificial Intelligence in Healthcare and Education
- PI3K/AKT/mTOR signaling in cancer
- Gastrointestinal disorders and treatments
- Gallbladder and Bile Duct Disorders
- Colorectal Cancer Screening and Detection
- X-ray Diffraction in Crystallography
- Diabetes and associated disorders
- Radiomics and Machine Learning in Medical Imaging
- Lipid metabolism and disorders
- Immune cells in cancer
- Neuroscience of respiration and sleep
- Glutathione Transferases and Polymorphisms
- Microbial Metabolites in Food Biotechnology
- Protein Kinase Regulation and GTPase Signaling
- Machine Learning in Healthcare
Changhai Hospital
2011-2025
Second Military Medical University
2012-2025
Naval University of Engineering
2025
National Clinical Research Center for Digestive Diseases
2024
Mayo Clinic
2024
Shanghai Institute of Hematology
2022
State Key Laboratory of Organic-Inorganic Composite Materials
2020
Beijing University of Chemical Technology
2020
The University of Texas MD Anderson Cancer Center
2012-2019
Canon (Japan)
2016
We demonstrate that positively-charged NBD amines can effectively scavenge biological H<sub>2</sub>S in live cells and mice.
Abstract Artificial intelligence (AI) is an epoch-making technology, among which the 2 most advanced parts are machine learning and deep algorithms that have been further developed by learning, it has partially applied to assist EUS diagnosis. AI-assisted diagnosis reported great value in of pancreatic tumors chronic pancreatitis, gastrointestinal stromal tumors, esophageal early cancer, biliary tract, liver lesions. The application AI still some urgent problems be solved. First, development...
Chronic inflammation (CI) is a risk factor for pancreatic cancer (PC) including the most common type, ductal adenocarcinoma (PDAC), but its role and mechanisms involved are unclear. To investigate of CI in PC, we generated genetic mouse models with specific presence or absence TP53. Mice were engineered to express either cyclooxygenase-2 (COX-2) IκB kinase-2 (IKK2), TP53+/+ TP53f/f specifically adult acinar cells by using full-length elastase promoter-driven Cre. Animals followed >80 weeks...
Background & AimsMutations in the trypsinogen gene (PRSS1) cause human hereditary pancreatitis. However, it is not clear how mutant forms of PRSS1 contribute to disease development. We studied effects expressing mice.MethodsWe expressed with and without mutation encoding R122H (PRSS1R122H) specifically pancreatic acinar cells under control a full-length elastase promoter. Mice that did express these transgenes were used as controls. given injections caerulein induce acute pancreatitis or...
Abstract Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the main types malignant tumor digestive system, and patient prognosis affected by difficulties in early diagnosis, poor treatment response, a high postoperative recurrence rate. Carbohydrate antigen 19-9 (CA19-9) has been widely used as biomarker for diagnosis follow-up PDAC patients. Nevertheless, production mechanism potential role CA19-9 progression have not yet elucidated. Methods: We performed single-cell RNA...
Abstract Generative artificial intelligence (AI) holds immense potential for medical applications, but the lack of a comprehensive evaluation framework and methodological deficiencies in existing studies hinder its effective implementation. Standardized assessment guidelines are crucial ensuring reliable consistent generative AI healthcare. Our objective is to develop robust, standardized tailored evaluating performance contexts. Through rigorous literature review utilizing Web Sciences,...
Abstract Autoimmune pancreatitis (AIP) is identified as a severe chronic immune‐related disorder in pancreas, including two subtypes. In this study, pancreatic lesions patients diagnosed either type 1 AIP or 2 are examined, and these patients’ peripheral blood at single‐cell level. Furthermore, flow cytometry, immunofluorescence, functional assays performed to verify the cell AIP, there notable increase amount of B cells plasma cells, IgG4+ key pathogenic AIP. The differentiation path...
OBJECTIVES: Endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNAB) is a useful tool in the diagnosis of pancreatic masses. Genetic analysis these samples could increase sensitivity and specificity diagnosis. This study aimed to evaluate usefulness novel method for detection mutations theKRAS(Kirsten rat sarcoma-2 virus) gene cancer. METHODS: EUS-FNABs were performed on 82 patients with masses, including 54 cases ductal adenocarcinoma 28 non-malignant The biopsies...
EUS-guided tissue acquisition (EUS-TA) is the preferred method to acquire pancreatic cancer (PC) tissues. The factors associated with false-negative outcomes and inadequate samples should be explored gain an understanding of EUS-TA.
Abstract Background The secreted protein acidic and rich in cysteine ( SPARC ) plays a pivotal role regulating cell-matrix interactions tumor angiogenesis, proliferation, migration. Detection of gene methylation may be useful as tumorigenesis marker for early detection pancreatic cancer. Methods Methylation the transcriptional regulation region (TRR) was detected using bisulfite-specific (BSP) PCR-based sequencing analysis 40 cases cancer adjacent normal tissues, 6 chronic pancreatitis...
Enteropeptidase (EP) is a type II transmembrane serine protease and physiological activator of trypsinogen. Extensive studies related to EP have been conducted date. However, no bibliometric analysis has systematically investigated this theme. Our study aimed visualize the current landscape frontier trends scientific achievements on EP, provide an overview past 120 years insights for researchers clinicians facilitate future collaborative research clinical intervention.Quantitative...
Validation of serum tumor biomarkers in predicting advanced cystic mucinous neoplasm the pancreas
Cathepsin B (CTSB) is a lysosomal protease implicated in the progression of various diseases. A large number CTSB-related studies have been conducted to date. However, there no comprehensive bibliometric analysis on this subject. In our study, we performed quantitative publications retrieved from Science Citation Index Expanded (SCIE) Web Core Collection (reference period: 2011-2021). total 3,062 original articles and reviews were retrieved. The largest USA (n = 847, 27.66%). research output...
Replacement of the exocrine parenchyma by fibrous tissue is a main characteristic chronic pancreatitis. Understanding mechanisms pancreatic fibrogenesis critical for development preventive and therapeutic interventions. Cyclooxygenase-2 (COX-2), rate-limiting enzyme prostaglandin synthesis, expressed in patients with However, it unknown whether COX-2 can cause To investigate roles acinar pancreatitis, was ectopically specifically cells transgenic mice. Histopathological changes expression...
Background: Calcium silicate biomaterials (CSB) have witnessed rapid development in the past 30 years. This study aimed to accomplish a comprehensive bibliometric analysis of published research literature on CSB for biomedical applications and explore hotspot current status. Methods: Articles related last three decades (1990-2020) were retrieved from Web Science Core Collection. The R bibliometrix package VOSviewer used construct publication outputs collaborative networking among authors,...
ABSTRACT Background and Objectives EUS is recommended for guiding pancreatic tissue acquisition in suspected autoimmune pancreatitis (AIP) cases. However, there a lack of comparative research on the effectiveness between EUS-guided fine-needle aspiration (EUS-FNA) biopsy (EUS-FNB) diagnosing AIP China. This study aimed to evaluate diagnostic accuracy (EUS-TA) specifically type 1 AIP. Methods Between 2010 2023, individuals with who received EUS-TA at Changhai Hospital were included study....