A5026461983- Sulfur Compounds in Biology
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Sulfur-Based Synthesis Techniques
- Genomics, phytochemicals, and oxidative stress
- Selenium in Biological Systems
- Alcohol Consumption and Health Effects
- Neuroscience of respiration and sleep
- Synthesis and biological activity
- Metal complexes synthesis and properties
- Polyamine Metabolism and Applications
- Luminescence and Fluorescent Materials
- Click Chemistry and Applications
- Odor and Emission Control Technologies
- Organoselenium and organotellurium chemistry
- Metabolism and Genetic Disorders
- Advanced Nanomaterials in Catalysis
- Enzyme function and inhibition
- Nonlinear Optical Materials Studies
- Redox biology and oxidative stress
- Industrial Gas Emission Control
- Porphyrin and Phthalocyanine Chemistry
University of Oregon
2017-2023
Impact
2020
Instituto de Ciencia de Materiales de Sevilla
2020
Impact Technology Development (United States)
2020
Hydrogen sulfide (H2S) is an important biomolecule, and responsive chemical tools for its delivery are needed. Here, we utilize the photocleavable o-nitrobenzyl group to unmask caged thiocarbamates access photoactivated H2S releasing molecules. These donors function by initial release of carbonyl (COS), which quickly hydrolyzed carbonic anhydrase (CA). Our investigations demonstrate that o-nitrobenzyl-caged can serve as a donor platform bio-orthogonal stimulated COS/H2S.
We demonstrate that positively-charged NBD amines can effectively scavenge biological H<sub>2</sub>S in live cells and mice.
Fluorophores are powerful tools for interrogating biological systems. Carbon nanotubes (CNTs) have long been attractive materials imaging due to their near-infrared excitation and bright, tunable optical properties. The difficulty in synthesizing functionalizing these with precision, however, has hampered progress this area. nanohoops, which macrocyclic CNT substructures, carbon nanostructures that possess ideal photophysical characteristics of nanomaterials, while maintaining the precise...
Hydrogen selenide (H2Se) is a central metabolite in the biological processing of selenium for incorporation into selenoproteins, which play crucial antioxidant roles systems. Despite being integral to proper physiological function, this reactive species (RSeS) has received limited attention. We recently reported an early example H2Se donor (TDN1042) that exhibited slow, sustained release through hydrolysis. Here we expand technology based on P═Se motif develop cyclic-PSe compounds with...
Sulfane sulfur, or S<sup>0</sup>, is found in polysulfide and persulfide compounds biology. We demonstrate that modified cyclodextrins can solubilize S<sub>8</sub> water, increase its reactivity with biological nucleophiles, enable delivery to live cells.
Several phosphaquinolinone derivatives have been synthesized and characterized to explore their usefulness in the realm of cell imaging. Solution-state photophysical properties both aqueous organic solutions were collected for these derivatives. Additionally, CCK-8 viability assays fluorescent imaging HeLa cells incubated with new heterocyclic show evidence favorable permeability, viability, moderate intracellular localization when appended well-known morpholine targeting motif.