A5091367326- Pancreatic and Hepatic Oncology Research
- Phagocytosis and Immune Regulation
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Peptidase Inhibition and Analysis
- Cancer Research and Treatments
- Acute Kidney Injury Research
- Anesthesia and Neurotoxicity Research
- Mast cells and histamine
- Cancer-related molecular mechanisms research
- Receptor Mechanisms and Signaling
- Nanoparticle-Based Drug Delivery
- Molecular Biology Techniques and Applications
- RNA modifications and cancer
- Signaling Pathways in Disease
- Mass Spectrometry Techniques and Applications
- Cancer-related gene regulation
- Adenosine and Purinergic Signaling
- Nanoplatforms for cancer theranostics
- Melanoma and MAPK Pathways
- Drug Transport and Resistance Mechanisms
- Fibroblast Growth Factor Research
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer-related Molecular Pathways
- Circular RNAs in diseases
The University of Texas MD Anderson Cancer Center
2011-2025
Ardent Sound (United States)
2024
Xinjiang Production and Construction Corps
2024
Mianyang Central Hospital
2024
Baylor College of Medicine
2005-2022
Kaifeng City Children's Hospital
2020
Centre for Cancer Biology
2008
Genetic mutations that give rise to active mutant forms of Ras are oncogenic and found in several types tumor. However, such not clear biomarkers for disease, since they frequently detected healthy individuals. Instead, it has become elevated levels activity critical Ras-induced tumorigenesis. the mechanisms underlying production pathological unclear. Here, we show presence Ras, inflammatory stimuli initiate a positive feedback loop involving NF-κB further amplifies levels. Stimulation...
Abstract The mechanisms that allow cancer cells to adapt the typical tumor microenvironment of low oxygen and glucose high lactate are not well understood. GPR81 is a receptor recently identified in adipose muscle has been investigated cancer. In current study, we examined expression function cells. We found was present colon, breast, lung, hepatocellular, salivary gland, cervical, pancreatic carcinoma cell lines. Examination tumors resected from patients with indicated 94% (148 158)...
Abstract Purpose: Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes cancer death. No effective therapy currently available for PDAC because lack understanding mechanisms to its growth and development. Inflammatory cells, particularly mast have been shown play key roles in some cancers. We carried out this study test hypothesis that cells tumor microenvironment are essential tumorigenesis. Experimental Design: The presence inflammatory at various stages development was...
Lipocalin-2 (LCN2) promotes malignant development in many cancer types. LCN2 is upregulated patients with pancreatic ductal adenocarcinoma (PDAC) and obese individuals, but whether it contributes to PDAC unclear. In this study, we investigated the effects of Lcn2 depletion on diet-induced obesity, inflammation, development. Mice acinar cell-specific expression KrasG12D were crossed Lcn2-depleted animals fed isocaloric diets varying amounts fat content. Pancreas collected analyzed for...
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer death in USA, accounting for ~40,000 deaths annually. The dismal prognosis PDAC largely due to its late diagnosis. Currently, most sensitive diagnosis requires invasive procedures, such as endoscopic ultrasonography, which has inherent risks and accuracy that highly operator dependent. Here we took advantage a general characteristic solid tumors, acidic microenvironment generated by-product metabolism, develop...
Background The existence of immunologically ‘cold tumors’ frequently found across a wide spectrum tumor types represents significant challenge for cancer immunotherapy. Cold tumors have poor baseline pan-leukocyte infiltration, including low prevalence cytotoxic lymphocytes, and not surprisingly respond unfavorably to immune checkpoint (IC) inhibitors. We hypothesized that cold harbor mechanism escape upstream independent ICs may be driven by biology rather than differences in mutational...
<h3>Background and Aims</h3> Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer death in USA. Surgical resection only effective treatment; however, 20% patients are candidates for surgery. The ability to detect early PDAC would increase availability surgery improve patient survival. This study assessed feasibility using enzymatic activity cathepsin E (Cath E), a protease highly specifically expressed PDAC, as novel biomarker detection pancreas-bearing pancreatic...
Anterior gradient 2 (AGR2) promotes cancer growth, metastasis, and resistance to therapy via unknown mechanisms. We investigated the effects of extracellular AGR2 signaling through orphan glycosylphosphatidylinositol-linked receptor C4.4A in pancreatic ductal adenocarcinoma (PDAC). Proliferation, migration, invasion, apoptosis were measured using colorimetric, Boyden chamber, FACS analyses. developed blocking mAbs against tested their effects, along with siRNAs, on cell functions orthotopic...
Chronic inflammation (CI) is a risk factor for pancreatic cancer (PC) including the most common type, ductal adenocarcinoma (PDAC), but its role and mechanisms involved are unclear. To investigate of CI in PC, we generated genetic mouse models with specific presence or absence TP53. Mice were engineered to express either cyclooxygenase-2 (COX-2) IκB kinase-2 (IKK2), TP53+/+ TP53f/f specifically adult acinar cells by using full-length elastase promoter-driven Cre. Animals followed >80 weeks...
Background TM4SF1 is overexpressed in pancreatic ductal adenocarcinoma (PDAC) and affects the development of this cancer. Also, multidrug resistance (MDR) generally associated with tumor chemoresistance However, correlation between MDR remains unknown. This research aims to investigate effect on gemcitabine PDAC explore possible molecular mechanism MDR. Methods The expression was evaluated cancer cell lines human duct epithelial (HPDE) by quantitative RT-PCR. siRNA transfection carried out...
DKK3 is produced by the stroma in pancreatic cancer, promotes tumor progression and resistance to therapy, a therapeutic target.
PI3K/mTOR inhibition leads to apoptosis of NOTCH1-mutant head and neck squamous cell carcinoma (HNSCC) cells. We tested the efficacy inhibitor bimiralisib in patients with HNSCC.Patients recurrent/metastatic HNSCC who had progressed during chemotherapy immunotherapy received until unacceptable toxicity or progression. To assess whether NOTCH1 mutations can be detected blood, we measured circulating tumor DNA (ctDNA). activated protein levels, quantitated cleaved (cl-NOTCH) by...
The maxianion channel is widely expressed in many cell types, where it fulfills a general physiological function as an ATP-conductive gate for cell-to-cell purinergic signaling. Establishing the molecular identity of this crucial to understanding mechanisms regulated ATP release. A mitochondrial porin (voltage-dependent anion (VDAC)) located plasma membrane has long been considered molecule underlying activity, based upon similarities biophysical properties these two channels and purported...
Pancreatic ductal adenocarcinoma (PDAC) is highly malignant disease that the fourth leading cause of cancer-related death in US. Gene therapy using AAV vectors to selectively deliver genes PDAC cells an attractive treatment option for pancreatic cancer. However, most serotypes display a broad spectrum tissue tropism and none existing specifically target cells. This study tests hypothesis AAV2 can be genetically re-engineered by modifying capsid surface peptide has previously been shown bind...
Introduction: Pancreatic ductal adenocarcinoma (PDAC) and hepatocellular carcinoma (HCC) remain the leading causes of cancer-related mortality, with poor outcomes. This study comprehensively evaluated mechanisms polymeric micelles co-encapsulating cyclopamine (CPA) paclitaxel (PTX) (M-CPA/PTX, ONP-001) effectiveness against HCC PDAC. The dual-drug delivery system targets embryonic signaling pathways, such as Hedgehog (Hh), which drives tumor progression resistance. Methods: CPA PTX were...
ABSTRACT We identified frequent inactivating notch1 mutations in HNSCC over a decade ago, indicating its role as tumor suppressor—unlike oncogenic function leukemias and salivary gland tumors. However, there has been much debate the literature regarding possible well, based on reports that signaling drives growth cancer stem cell phenotype some lines patient samples. Clarifying whether NOTCH1 occasionally functions an driver is crucial to prognosis personalized therapy of patients with...
Although patients with Glioblastoma multiforme (GBM) have grave prognosis, significant variability in patient outcome is observed. The objective of this study to identify a molecular signature for GBM prognosis. We subjected 355 mRNA and microRNA expression profiles elastic net-regulated Cox regression identification an integrated RNA A prognostic index (PI) was generated stratification. Survival comparison conducted by Kaplan-Meier method general multivariate procedure applied evaluate the...
Pancreatic stellate cells (PSC) have been recognized as the principal responsible for production of fibrosis in pancreatic ductal adenocarcinoma (PDAC). Recently, PSCs noted to share characteristics with monocyte-macrophage lineage (MML cells). Thus, we tested whether could be targeted nitrogen-containing bisphosphonates (NBP; pamidronate or zoledronic acid), which are potent MML cell inhibitors. In addition, NBPs treatment combination nanoparticle albumin-bound paclitaxel (nab-paclitaxel)...
MAP4K5 plays an important role in regulating a range of cellular responses and is involved Wnt signaling hematopoietic cells. However, its functions human malignancies have not been studied. The major objectives this study are to examine the expression, clinical significance pancreatic ductal adenocarcinoma (PDAC).The expression levels MAP4K5, E-cadherin, vimentin, carboxylesterase 2 (CES2) were examined by immunohistochemistry 105 PDAC matched non-neoplastic pancreas samples from our...
Role of cyclin dependent kinase 9(CDK9) as a potential target in esophageal adenocarcinoma (EAC) is unknown. We investigated CDK9 protein expression EAC and Barrett's esophagus role oncogenic processes vitro murine xenografts. The was significantly higher compared to patient samples. Stable shCDK9 SKGT4 reduced proliferation by 37% at day 4, increased apoptosis 48 hours induced G1 cell cycle arrest (58.4% vs. 45.8%) controls cells. SKGT4-shCDK9 cell-derived tumors were smaller than control...
Abstract The NIH categorizes Biofield Therapy (BT) as therapeutic approaches within energy medicine that involve using the body's field (biofield) for benefit. Although controversial, in some cases devices have been developed mimic electromagnetic fields (EMF) are emitted from people when delivering BTs. We previously reported BT significantly inhibited growth of pancreatic cancer cells and liver metastasis their relevant animal models mediated part through modification cell cycle,...