A5077006027- Childhood Cancer Survivors' Quality of Life
- Burn Injury Management and Outcomes
- Injury Epidemiology and Prevention
- Orthopedic Surgery and Rehabilitation
- Cardiac Arrest and Resuscitation
- Wound Healing and Treatments
- Cancer survivorship and care
- Palliative Care and End-of-Life Issues
- Acute Lymphoblastic Leukemia research
- Lymphoma Diagnosis and Treatment
- Family Support in Illness
- Chronic Lymphocytic Leukemia Research
- Foot and Ankle Surgery
- Glioma Diagnosis and Treatment
- Elbow and Forearm Trauma Treatment
- Shoulder Injury and Treatment
- Brain Metastases and Treatment
- Respiratory Support and Mechanisms
- Economic and Financial Impacts of Cancer
- Adolescent and Pediatric Healthcare
- Traumatic Brain Injury and Neurovascular Disturbances
- Mesenchymal stem cell research
- Lung Cancer Treatments and Mutations
- Cancer Treatment and Pharmacology
- Muscle activation and electromyography studies
The University of Texas MD Anderson Cancer Center
2020-2025
Scripps MD Anderson Cancer Center
2023-2024
The University of Texas Medical Branch at Galveston
2014-2023
University of California, Riverside
2023
Moffitt Cancer Center
2023
Mayo Clinic
2023
WinnMed
2023
Cancer Research Center
2023
Texas Tech University
2023
Fukushima Medical University
2022
Brown adipose tissue (BAT) has attracted scientific interest as an antidiabetic owing to its ability dissipate energy heat. Despite a plethora of data concerning the role BAT in glucose metabolism rodents, (if any) humans remains unclear. To investigate whether activation alters whole-body homeostasis and insulin sensitivity humans, we studied seven BAT-positive (BAT+) men five BAT-negative (BAT−) under thermoneutral conditions after prolonged (5–8 h) cold exposure (CE). The two groups were...
To estimate the incidence of immune checkpoint inhibitor-related myositis (ICI-myositis) in cancer patients receiving ICIs, and to report associated clinical manifestations, patterns care, outcomes.We identified a retrospective cohort ICIs between 2016 2019 seen at University Texas MD Anderson Cancer Center. Cases ICI-myositis were using International Classification Disease codes confirmed by reviewing medical records pathology, as available.A total 9,088 received an ICI. Thirty-six (0.40%)...
PURPOSE In this study, we aimed to evaluate the association between Extension for Community Healthcare Outcomes-Palliative Care (ECHO-PC; ECHO Model–Based comprehensive educational and telementoring intervention) health care professionals (HCPs) change in patient-reported quality-of-life (QOL; Functional Assessment of Cancer Therapy-General [FACT-G]) among patients with advanced cancer. We also examined ECHO-PC changes symptom distress (Edmonton Symptom Scale [ESAS]), patient experience...
Background: A cannulated screw is currently used to reduce and stabilize diastasis at the Lisfranc joint. The requires removal may break in situ. suture button does not have these disadvantages, but it known if can provide stability similar that provided by a or an intact ligament. objective of present study was compare with when associated ligament injury. Methods: Fourteen fresh-frozen, paired cadaveric feet were dissected expose dorsal region. registration marker triad consisting three...
Abstract Introduction Propranolol, a nonselective β-blocker, exerts an indirect effect on the vasculature by leaving α-adrenergic receptors unopposed, resulting in peripheral vasoconstriction. We have previously shown that propranolol diminishes blood following burn injury increasing vascular resistance. The purpose of this study was to investigate whether wound healing and perioperative hemodynamics are affected administration severely burned adults. Methods Sixty-nine adult patients with...
BACKGROUND This study was designed to adapt the Elixhauser comorbidity index for 4 cancer‐specific populations (breast, prostate, lung, and colorectal) compare 3 versions of score (individual comorbidities, summary score, score) with Charlson predicting 2‐year survival types cancer. METHODS cohort used Texas Cancer Registry–linked Medicare data from 2005 2011 older patients diagnosed breast (n = 19,082), prostate 23,044), lung 26,047), or colorectal cancer 16,693). For each cohort, were...
With improvements in survival for patients with metastatic cancer, long-term local control of brain metastases has become an increasingly important clinical priority. While consensus guidelines recommend surgery followed by stereotactic radiosurgery (SRS) lesions >3 cm, smaller (≤3 cm) treated SRS alone elicit variable responses. To determine factors influencing this response to SRS, we analyzed outcomes ≤3 cm diameter no prior systemic therapy frame-based single-fraction SRS. Following 259...
Acute alterations in skeletal muscle protein metabolism are a well-established event associated with the stress response to burns. Nevertheless, long-lasting effects of burn injury on turnover incompletely understood. This study was undertaken investigate fractional synthesis (FSR) and breakdown (FBR) rates pediatric patients (n = 42, >30% total body surface area burns) for up 1 year after injury. Skeletal kinetics were measured post-prandial state following bolus injections 13C6 15N...
Abstract Zika virus (ZIKV) emerged from obscurity in 2013 to spread Asia the South Pacific and Americas, where millions of people were infected, accompanied by severe disease including microcephaly following congenital infections. Phylogenetic studies have shown that ZIKV evolved Africa later Asia, Asian lineage is responsible for recent epidemics Americas. However, reasons sudden emergence remain enigmatic. Here we report evolutionary analyses revealed four mutations, which occurred just...
Administration of oxandrolone, a nonaromatizable testosterone analog, to children for 12 months following severe burn injury has been shown improve height, increase bone mineral content (BMC), reduce cardiac work, and augment muscle strength. Surprisingly, the in BMC persists well beyond period oxandrolone administration. This study was undertaken determine if administration 2 years yields greater effects on long-term density (BMD). Patients between 0 18 age with ≥30% total body surface area...
The long-term impact of burn trauma on skeletal muscle bioenergetics remains unknown. Here, the authors determined respiratory capacity and function mitochondria in healthy individuals victims for up to 2 years postinjury. Biopsies were collected from m. vastus lateralis 16 men (26 ± 4 years) 69 children (8 5 with burns encompassing ≥30% their total BSA. Seventy-nine biopsies cohorts at weeks (n = 18), 6 months 12 25), 24 18) postburn. Hypermetabolism was by difference predicted measured...
Background: The hypercatabolic response in severely burned pediatric patients is associated with increased production of catecholamines and corticosteroids, decreased formation testosterone, reduced strength alongside growth arrest for up to 2 years after injury. We have previously shown that, the population, administration testosterone analog oxandrolone improves lean body mass accretion bone mineral content that β1-, β2-adrenoceptor antagonist propranolol decreases cardiac work resting...
LamB (maltoporin) of Escherichia coli outer membrane was reconstituted into artificial lipid bilayer membranes. The channel contains a binding site for sugars and is blocked ions when the occupied by sugar. on off reactions sugar cause an increase noise current through channel. sugar-induced maltoporin used evaluation sugar-binding kinetics different maltooligosaccharide series sucrose. rate constant between 10(6) 10(7) M-1.s-1 maltooligosaccharides corresponds to movement from aqueous phase...
There are inconsistencies in the descriptive anatomy of Lisfranc ligament. No information is available on orientation fibers or presence bundles, nor there 3-dimensional anatomic data ligaments their attachments. This study assessed ligament and its attachment sites.A total 37 cadaver feet were dissected to expose attachments at joint. The plantar outlined separately then removed with outlines preserved. A digitizer was used digitize bony articular surfaces, as well sites, approximately 1 mm...
Abstract Background: There is a growing population of adolescent and young adult (AYA, age 15–39 years) acute leukemia survivors in whom long-term mortality outcomes are largely unknown. Methods: The current study utilized the Surveillance, Epidemiology, End Results (SEER) registry to assess AYA 5-year survivors. impact diagnosis age, sex, race/ethnicity, socioeconomic status, decade on survival were assessed utilizing an accelerated failure time model. Results: A total 1,938 lymphoblastic...
PI3K/mTOR inhibition leads to apoptosis of NOTCH1-mutant head and neck squamous cell carcinoma (HNSCC) cells. We tested the efficacy inhibitor bimiralisib in patients with HNSCC.Patients recurrent/metastatic HNSCC who had progressed during chemotherapy immunotherapy received until unacceptable toxicity or progression. To assess whether NOTCH1 mutations can be detected blood, we measured circulating tumor DNA (ctDNA). activated protein levels, quantitated cleaved (cl-NOTCH) by...
Survivors of adolescent and young adult (AYA) cancer experience significant psychological distress encounter barriers to accessing mental health care. Few studies have investigated racial/ethnic disparities in outcomes among AYA survivors, none compared within a racially minoritized population.
Abstract The concurrent use of medications can either compromise or enhance treatment (Tx) outcomes in patients with solid tumors (pts) receiving immunotherapy compounds (IO) including monoclonal antibodies (Abs), fusion proteins (FP), immune modulators (IM), oncolytic viruses (OV) and vaccines (VAC). To assess the impact on Tx outcomes, we conducted a retrospective analysis pts enrolled early IO clinical trials at Department Investigational Cancer Therapeutics (ICT) MD Anderson Center...