A5033226078- Viral Infections and Immunology Research
- CAR-T cell therapy research
- Cytokine Signaling Pathways and Interactions
- Glioma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Monoclonal and Polyclonal Antibodies Research
- Inflammatory Myopathies and Dermatomyositis
- Brain Metastases and Treatment
- EEG and Brain-Computer Interfaces
- Advanced Neuroimaging Techniques and Applications
- Autoimmune Neurological Disorders and Treatments
- Cancer Treatment and Pharmacology
- Neurological Complications and Syndromes
- Neurobiology of Language and Bilingualism
- Peripheral Neuropathies and Disorders
- Myasthenia Gravis and Thymoma
- Advanced MRI Techniques and Applications
- CNS Lymphoma Diagnosis and Treatment
- Transcranial Magnetic Stimulation Studies
- Neural dynamics and brain function
- Chronic Lymphocytic Leukemia Research
- Functional Brain Connectivity Studies
- Polyomavirus and related diseases
- Pharmacological Effects and Toxicity Studies
- Intraoperative Neuromonitoring and Anesthetic Effects
The University of Texas MD Anderson Cancer Center
2016-2025
European School of Oncology
2014-2023
Scripps MD Anderson Cancer Center
2020-2022
Neurology, Inc
2014
Ipilimumab is a novel FDA-approved recombinant human monoclonal antibody that blocks cytotoxic T-lymphocyte antigen-4 and has been used to treat patients with metastatic melanoma. Immune-related neurological adverse effects include inflammatory myopathy, aseptic meningitis, posterior reversible encephalopathy syndrome, Guillain-Barré myasthenia gravis–type sensorimotor neuropathy, enteric neuropathy. To date, there no report for ipilimumab-induced chronic demyelinating polyneuropathy (CIDP),...
Abstract There is a critical need for effective treatments leptomeningeal disease (LMD). Here, we report the interim analysis results of an ongoing single-arm, first-in-human phase 1/1b study concurrent intrathecal (IT) and intravenous (IV) nivolumab in patients with melanoma LMD. The primary endpoints are determination safety recommended IT dose. secondary endpoint overall survival (OS). Patients treated alone cycle 1 IV included subsequent cycles. We 25 metastatic using 5, 10, 20 50 mg...
JC virus, the cause of progressive multifocal leukoencephalopathy (PML), and BK virus are genetically similar share sequence homology in immunogenic proteins. We treated three immunosuppressed patients with PML ex vivo-expanded, partially HLA-matched, third-party-produced, cryopreserved virus-specific T cells. The immunosuppression these was due to conditioning regimen for cord-blood transplantation one patient, a myeloproliferative neoplasm ruxolitinib another, acquired immunodeficiency...
The Endothelial Activation and Stress Index (EASIX) score, defined as [(creatinine × lactate dehydrogenase [LDH])/platelets], is a marker of endothelial activation that has been validated in the allogeneic hematopoietic stem cell transplant setting. one mechanisms driving immune-mediated toxicities patients treated with chimeric antigen receptor-T (CAR-T)-cell therapy. This study's objective was to evaluate association between EASIX other laboratory parameters collected before...
High-frequency oscillations in local field potentials recorded with intracranial EEG are putative biomarkers of seizure onset zones epileptic brain. However, localized 80-500 Hz can also be from normal and non-epileptic cerebral structures. When defined only by rate or frequency, physiological high-frequency indistinguishable pathological ones, which limit their application epilepsy presurgical planning. We hypothesized that occur a repetitive fashion similar waveform morphology specifically...
Neurotoxicity or immune effector cell-associated neurotoxicity syndrome (ICANS) is the second most common acute toxicity after chimeric antigen receptor (CAR) T-cell therapy. However, there are limited data on clinical and radiologic correlates of ICANS. We conducted a cohort analysis 100 consecutive patients with relapsed refractory large B-cell lymphoma (LBCL) treated standard care axicabtagene ciloleucel (axi-cel). ICANS was graded according to an objective grading system. Neuroimaging...
To estimate the incidence of immune checkpoint inhibitor-related myositis (ICI-myositis) in cancer patients receiving ICIs, and to report associated clinical manifestations, patterns care, outcomes.We identified a retrospective cohort ICIs between 2016 2019 seen at University Texas MD Anderson Cancer Center. Cases ICI-myositis were using International Classification Disease codes confirmed by reviewing medical records pathology, as available.A total 9,088 received an ICI. Thirty-six (0.40%)...
The object of this study was to describe the utility and safety using a single probe for combined intraoperative navigation subcortical mapping in an MR (iMR) imaging environment during brain tumor resection.The authors retrospectively reviewed those patients who underwent resection iMR environment, as well functional electrophysiological monitoring with continuous motor evoked potential (MEP) direct diffusion tensor tractography. RESULTS As navigational tool monopolar used safe accurate....
Tailored craniotomies for awake procedures limit cortical exposure. Recently we demonstrated that the identification of eloquent areas increased risk postoperative deficits. However, it was not clear whether observed neurological deficits were caused by proximity functional cortex to tumor [cortical injury] or subcortical injury.We hypothesize injury during resection is an important predictor compared injury.A retrospective review 214 patients undergoing craniotomy carried out in whom...
Object The object of this study was to describe the experience combining awake craniotomy techniques with high-field (1.5 T) intraoperative MRI (iMRI) for tumors adjacent eloquent cortex. Methods From a prospective database authors obtained and evaluated records all patients who had undergone procedures cortical subcortical mapping in iMRI suite. integration these two modalities assessed respect safety, operative times, workflow, extent resection (EOR), neurological outcome. Results Between...
Preoperative diffusion tensor imaging (DTI) is used to demonstrate corticospinal tract (CST) position. Intraoperative brain shifts may limit preoperative DTI value, and studies characterizing such are lacking.To examine tumor characteristics that could predict intraoperative shift in tumor-to-CST distance using high-field magnetic resonance imaging.We retrospectively evaluated DTIs, pathology, of patients who underwent resection an intra-axial adjacent the CST identify covariates...
Atezolizumab is a monoclonal antibody that targets programmed death ligand-1. Treatments with this drug may cause immune-related adverse events by creating an exaggerated inflammatory response. The most common side effects are fatigue, rash, and gastrointestinal symptoms. Cases of central nervous system toxicity such as encephalitis encephalopathy uncommon. We present the case 53-year-old female metastatic squamous cell carcinoma cervix who presented to emergency room 13 days after receiving...
Abstract Immune checkpoint therapies (ICT) can induce life-threatening immune-related adverse events, including myocarditis and myositis, which are rare but often concurrent. The molecular pathways immune subsets underlying these toxicities remain poorly understood. To address this need, we performed single-cell RNA sequencing of heart skeletal muscle biopsies obtained from living patients with cancers treated ICTs admitted to the hospital and/or myositis (overlapping plus n = 10;...
10008 Background: MM pts with LMD have a dismal prognosis, median overall survival (OS) < 3 months and no approved therapies. IT administration of interleukin-2 (IL2) achieves in ~15% pts, but at cost severe toxicities. Given the favorable clinical activity safety systemic anti-PD1, we hypothesized that N is safe can achieve benefit LMD. Methods: The primary objectives this first-in-human study (NCT03025256) were to determine maximum tolerated dose (MTD) given IV Eligible had MM, ECOG PS...
It is well known that motor cortical oscillatory components are modulated in their amplitude during voluntary and imagined movements. These patterns have been used to develop brain-machine interfaces (BMI) which focused mostly on movement kinematics. In contrast, there only a few studies the relation between brain activity control of force, particular, grasping primary importance for common daily activities. this study, we recorded intraoperative high-density electrocorticography (ECoG) from...
This article reports a fatal case of human herpesvirus 6 (HHV-6) myelitis following CD19-targeted chimeric antigen receptor T-cell therapy. Infection from HHV-6 reactivation after haematopoietic stem cell transplant is established, and outside this population limited to reports. The patient developed cytokine release syndrome immune effector cell-associated neurotoxicity that responded corticosteroids both clinically on imaging. Subsequently, ascending flaccid paralysis developed, leading...
Background: Tumors infiltrating the precentral gyrus remain a unique operative challenge. In this study, we explored novel approach for awake craniotomy involving patient playing drum pad during resection of low-grade glioma, with use preoperative navigated transcranial magnetic stimulation (nTMS)-generated diffusion tensor imaging (DTI) and high-density real-time electrocorticography (ECoG). Observation: A 36-year-old left-handed male glioma in left hemisphere hand knob region had grand mal...