A5100684466- Pain Mechanisms and Treatments
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Lung Cancer Treatments and Mutations
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Pain Management and Opioid Use
- RNA modifications and cancer
- Mycobacterium research and diagnosis
- Genomics and Phylogenetic Studies
- Effects of Radiation Exposure
- Bone Metabolism and Diseases
- Cancer Mechanisms and Therapy
- Neuropeptides and Animal Physiology
- Berberine and alkaloids research
- Cancer Treatment and Pharmacology
- Lung Cancer Diagnosis and Treatment
- Plant-based Medicinal Research
- Colorectal Cancer Treatments and Studies
- RNA and protein synthesis mechanisms
- Pharmacological Effects of Natural Compounds
- Wnt/β-catenin signaling in development and cancer
- Cancer, Hypoxia, and Metabolism
- Angiogenesis and VEGF in Cancer
Guang’anmen Hospital
2016-2025
China Academy of Chinese Medical Sciences
2012-2025
Henan Forestry Vocational College
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
State Key Laboratory of Virology
2024
Beijing University of Chinese Medicine
2017-2024
Capital Medical University
2017-2024
Zhongnan Hospital of Wuhan University
2024
Wuhan University
2024
Beijing YouAn Hospital
2024
Dendritic cells play a pivotal role in host immune defense, such as elimination of foreign pathogen and inhibition tumorigenesis. In this paper, we report that [Gd@C82(OH)22]n could induce phenotypic maturation dendritic by stimulating DC production cytokines including IL-12p70, upregulating co-stimulatory (CD80, CD83, CD86) MHC (HLA-A,B,C HLA-DR) molecules, switching DCs from CCL5-responsive to CCL19-responsive phenotype. We found can become functionally mature illustrated their capacity...
Colorectal cancer, a leading cause of cancer death, has been linked to inflammation and obesity. Berberine, an isoquinoline alkaloid, possesses anti‐inflammatory, anti‐diabetes anti‐tumor properties. In the azoxymethane initiated dextran sulfate sodium (AOM/DSS) promoted colorectal carcinogenesis mouse model, berberine treated mice showed 60% reduction in tumor number ( P = 0.009), 48% tumors <2 mm, 0.05); 94% 2–4 0.001), 100% >4 mm 0.02) compared vehicle mice. Berberine also decreased...
To investigate the role of Wnt–β-catenin signaling in bone remodeling, we analyzed phenotype female Axin2-lacZ knockout (KO) mice. We found that trabecular mass was significantly increased 6- and 12-month-old Axin2 KO mice formation rates were also 6-month-old compared with wild-type (WT) littermates. In vitro studies performed using marrow stromal (BMS) cells isolated from WT Osteoblast proliferation differentiation osteoclast reduced Nuclear β-catenin protein levels BMS derived deletion...
In chondrocytes, PTHrP maintains them in a proliferative state and prevents premature hypertrophy. The mechanism by which does this is not fully understood. Both Runx2 Runx3 are required for chondrocyte maturation. We recently demonstrated that cyclin D1 induces protein phosphorylation degradation. the present studies, we tested hypothesis regulates both stability through D1. analyzed effects of on function using COS cells, osteoprogenitor C3H10T1/2 cells chondrogenic RCJ3.1C5.18 cells....
Abstract Purpose: NAT10 (N-acetyltransferase 10) is a nucleolar protein, but may show subcellular redistribution in colorectal carcinoma. In this study, we evaluated membranous staining of carcinoma and its clinical implications, explored the mechanism regulation redistribution. Experimental Design: The expression NAT10, β-catenin, E-cadherin, GSK-3β were by immunohistochemistry 222 cases Regulation influence on cell motility analyzed with inhibitors GSK-3β, transfection wild-type or...
Cancer stem cells (CSCs) play an important role in cancer initiation, relapse and metastasis. To date, no specific medicine has been found to target CSCs as they are resistant most conventional therapies proliferate indefinitely. Compound Kushen Injection (CKI) widely used for patients with remarkable therapeutic effects Chinese clinical settings many years. This study focused on whether CKI could inhibit MCF-7 SP vitro vivo.The analysis of population the main genes Wnt signaling pathway...
Background: Bone cancer pain is currently a major clinical challenge for the management of patients, and cellular molecular mechanisms underlying spinal sensitization remain unclear. While several studies demonstrated critical role proteinase-activated receptor (PAR2) in pathogenesis types inflammatory or neuropathic pain, involvement PAR2 pertinent signaling central not determined yet rodent model bone pain. Findings: Implantation tumor cells into tibias induced significant thermal...
Chinese cancer patients often use Traditional Medicine (TCM) herbal medicine during or after active treatments. However, little is known about how TCM impacts outcomes. This study aimed to evaluate the association between therapy and survival outcomes in with stage II III colorectal cancer.We conducted an eight-center prospective cohort China among who had undergone radical resection for cancer. All received comprehensive conventional treatments according National Comprehensive Cancer...
Objective. To evaluate ginsenoside Rg3 combined with chemotherapy for non‐small‐cell lung cancer (NSCLC) treatment, in a meta‐analysis. Materials and Methods . We searched PubMed, EMBASE, the Cochrane Library, China National Knowledge Infrastructure, VIP Wanfang databases eligible studies. manually printed journals relevant textbooks. Statistical analyses were performed Revman 5.3 STATA 14.0 software packages. Results Twenty studies included. Ginsenoside could enhance response, improve...
Increasing evidence suggests that the failure of lung cancer treatment may occur as a result tumor invasion and metastasis. Signal transducer activator transcription 3 (STAT3), an epithelial-mesenchymal transition-inducing factor, is key signaling molecule involved in proliferation, apoptosis, metastasis cells. Sinomenine alkaloid compound with antineoplastic potential against variety The aim present study was to assess antitumor mechanisms sinomenine A549 human cell line. results...