A5007315094- Malaria Research and Control
- Traditional Chinese Medicine Analysis
- Drug-Induced Hepatotoxicity and Protection
- Computational Drug Discovery Methods
- Monoclonal and Polyclonal Antibodies Research
- Mosquito-borne diseases and control
- Pharmacological Effects of Natural Compounds
- Second Language Learning and Teaching
- Bioactive Natural Diterpenoids Research
- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
- Virus-based gene therapy research
- Multilingual Education and Policy
- Animal Virus Infections Studies
- Vascular Tumors and Angiosarcomas
- Dermatological diseases and infestations
- Science, Research, and Medicine
- Multi-Agent Systems and Negotiation
- Advanced Decision-Making Techniques
- Folklore, Mythology, and Literature Studies
- Bird parasitology and diseases
- Vector-borne infectious diseases
- Nicotinic Acetylcholine Receptors Study
- Cancer Immunotherapy and Biomarkers
- Venomous Animal Envenomation and Studies
Tianjin People's Hospital
2025
Tianjin Anding Hospital
2025
Guangzhou University of Chinese Medicine
2019-2024
Xinxiang University
2024
Guangzhou Medical University
2024
State Key Laboratory of Respiratory Disease
2024
First Hospital of Shanxi Medical University
2024
Shanxi Medical University
2024
First Affiliated Hospital of Guangzhou Medical University
2024
Sichuan University
2024
Abstract: Uric acid (UA) is the end product of purine metabolism in human, and imbalance between production excretion results disturbance serum uric (SUA). There evidence suggesting that pituitary-target gland hormones can affect UA through regulating activity xanthine oxidase transporters. Related endocrine diseases including thyroid dysfunction, polycystic ovary syndrome, acromegaly Cushing’s syndrome are often accompanied by elevated levels. In addition to direct influence abnormal...
We aimed to verify the impact of functional remediation (FR) on serum brain-derived neurotrophic factor (BDNF) and tyrosine kinase receptor B (TrkB) levels, explore biomechanism FR intervention in patients with euthymic bipolar disorder (BD). This is a randomized controlled, 12-week study participants into group (n=39) treatment as usual (TAU, n=42) at 1∶1 ratio. 17-Hamilton Depression Rating Scale-17 (HDRS-17), Young Mania Scale (YMRS), Measurement Treatment Research Improve Cognition...
Malaria remains a serious threat to global public health. With poor efficacies of vaccines and the emergence drug resistance, novel strategies control malaria are urgently needed. We developed erythrocyte membrane-camouflaged nanoparticles loaded with artemether based on growth characteristics Plasmodium. The could capture merozoites inhibit them from repeatedly infecting normal erythrocytes, owing interactions between heparin-like molecules membrane. Modification...
Haemaphysalis longicornis is a blood-sucking ectoparasite that can cause diseases by transmitting some pathogens to humans and animals. Paramyosin (Pmy) an immunomodulatory protein, which plays important role in immune reactions against parasites. In this study, we evaluated the protection elicited recombinant plasmids encoding H. Pmy rabbits. Rabbits vaccinated with pcDNA3.1(+)-Pmy developed high level of IgG compared control group, suggesting humoral response was induced vaccination. On...
Objective: Human umbilical cord mesenchymal stem cells (hUC-MSCs) have shown very attractive potential in clinical applications for the treatment of various diseases. However, data about reproductive and developmental toxicity hUC-MSCs remains insufficient. Thus, we assessed effects intravenous injection on reproduction development Sprague-Dawley rats. Methods: In fertility early embryonic study, were administered at dose levels 0, 6.0 × 106, 8.5 1.2 107/kg to male female rats during...
The strategy of drug repurposing has gained traction in the field cancer therapy as a means discovering novel therapeutic uses for established pharmaceuticals. Paroxetine (PX), selective serotonin reuptake inhibitor typically utilized treatment depression, demonstrated promise an agent combating cancer. Nevertheless, specific functions and mechanisms by which PX operates context triple-negative breast (TNBC) remain ambiguous. This study aimed to examine impact on TNBC cells vitro both...
Abstract Porcine Epidemic Diarrhea Virus (PEDV) poses a significant threat to neonatal piglets, particularly due the limited efficacy of existing vaccines and scarcity efficacious therapeutic drugs. Gegen Qinlian Decoction (GQD) has been employed for over two millennia in treating infectious diarrhea. Nonetheless, further scrutiny is required improve drug’s elucidate its underlying mechanisms action. In this study, modified GQD (MGQD) was developed demonstrated capacity inhibit replication...
Immune checkpoint inhibitor-related pneumonitis (CIP) stands out as a particularly severe adverse event caused by immune inhibitors, with substantial real-world incidence ranging from 13 to 19%. While systemic corticosteroids represent the standard treatment for CIP, therapeutic options become limited in cases where patients do not respond corticosteroid therapy. Such are classified having steroid-resistant often associated poor prognosis. This case study provides insight into symptoms,...
Gancao Xiexin decoction (GCXXD), a well-known classic traditional Chinese medicine prescription, is used to treat various oral ulcers, Behcet disease, gastrointestinal etc. However, there very little information on its safety. This study aimed investigate the acute and subacute toxicity of GCXXD in Sprague-Dawley rats. In study, rats were orally administered 10 g/kg three times day. Clinical signs abnormality mortality observed daily for 14 days. 0, 1.47, 3.83, or 28 The rats' clinical...
Artemisinin-hydroxychloroquine sulfate tablets (AH) are relatively inexpensive and a novel combination therapy for the treatment of all forms malaria, especially aminoquinine drug-resistant strains P. falciparum. Our aim was to assess pharmacokinetics (PK) toxicokinetics (TK) AH following oral administration in Sprague Dawley rats Beagle dogs by using liquid chromatography tandem mass spectrometry methods (LC-MS/MS). The PK studies were carried out eighteen at three doses six rounds after...
Wuzhuyu decoction (WZYD) is a well-known classic traditional Chinese medicine prescription and has been widely used to treat headache, nausea, vomiting, insomnia, etc. However, little published information available about its safety. Our aim was investigate the acute subacute oral toxicity of WZYD extract in rats following technical guidelines from China's National Medical Products Administration (NMPA) for single repeated doses studies drugs. Acute assessed via administration at 4 g/kg...
e20138 Background: Treatment options are limited for EGFR-TKIs-resistant advanced NSCLC. A retrospective study from our center showed that ICIs plus platinum-free, single-agent chemotherapy provided progression-free survival, overall response rate benefit, and a low of severe AEs in such pts. Meanwhile,there were many NSCLC patients after treatment failure with EGFR-TKIs who ECOG performance status was 2 ,they excluded existing prospective studies. This designed to further explore the...
The WHO recommends artemisinin-based combination regimens for uncomplicated Plasmodium falciparum malaria. One such is artemisinin-piperaquine tablets (ATQ). ATQ has outstanding advantages in anti-malarial, as good efficacy, fewer side effects, easy promotion and application deprived regions. However, the data about reproductive endocrine toxicity of remains insufficient. Thus, we assessed potential effects its individual components artemisinin (ART) piperaquine (PQ) on systems Wistar...
Artemisinin-hydroxychloroquine sulfate tablets (AH) are regarded as a relatively inexpensive and novel combination therapy for the treatment of various forms malaria, particularly aminoquinoline drugs-resistant strains Plasmodium falciparum. Our aim was to conduct acute subacute oral toxicity studies in non-rodents obtain more nonclinical data on safety AH. Acute evaluation performed beagle dogs at single doses 230, 530, 790, 1180, 2660, 5000 mg/kg. Beagle 0, 56, 84, 126 mg/kg were used...