A5101439947- Toxic Organic Pollutants Impact
- Pharmaceutical and Antibiotic Environmental Impacts
- Computational Drug Discovery Methods
- Nanoparticles: synthesis and applications
- Free Radicals and Antioxidants
- Effects and risks of endocrine disrupting chemicals
- Environmental Toxicology and Ecotoxicology
- Atmospheric chemistry and aerosols
- Water Quality Monitoring and Analysis
- Analytical Chemistry and Chromatography
- Carbon and Quantum Dots Applications
- Air Quality and Health Impacts
- Graphene and Nanomaterials Applications
- Electrochemical Analysis and Applications
- Advanced Nanomaterials in Catalysis
- Pesticide and Herbicide Environmental Studies
- Microplastics and Plastic Pollution
- Pesticide Residue Analysis and Safety
- Matrix Theory and Algorithms
- Advanced Optimization Algorithms Research
- Water Quality and Pollution Assessment
- Copper-based nanomaterials and applications
- HIV/AIDS Research and Interventions
- Diamond and Carbon-based Materials Research
- Nanocluster Synthesis and Applications
Dalian University of Technology
2016-2025
Yunnan Center for Disease Control And Prevention
2015-2025
China University of Mining and Technology
2022-2025
Xinxiang University
2024
Beijing Union University
2024
North China University of Technology
2023
Zibo Vocational Institute
2023
Liaoning Technical University
2023
Changsha Normal University
2022-2023
Zhongshan People's Hospital
2023
Background: Endocrine disrupting chemicals (EDCs) are xenobiotics that mimic the interaction of natural hormones and alter synthesis, transport, or metabolic pathways. The prospect EDCs causing adverse health effects in humans wildlife has led to development scientific regulatory approaches for evaluating bioactivity. This need is being addressed using high-throughput screening (HTS) vitro computational modeling. Objectives: In support Disruptor Screening Program, U.S. Environmental...
Hydroxylated polybrominated diphenyl ethers (HO-PBDEs) may disrupt thyroid hormone status because of their structural similarity to hormone. However, the molecular mechanisms interactions with receptors (TRs) are not fully understood.We investigated between HO-PBDEs and TRbeta identify critical features physicochemical properties related activity, develop quantitative structure-activity relationship (QSAR) models for activity HO-PBDEs.We used recombinant two-hybrid yeast assay determine...
Abstract Advanced data encryption requires the use of true random number generators (TRNGs) to produce unpredictable sequences bits. TRNG circuits with high degree randomness and low power consumption may be fabricated by using telegraph noise (RTN) current signals produced polarized metal/insulator/metal (MIM) devices as entropy source. However, RTN MIM made traditional insulators, i.e., transition metal oxides like HfO 2 Al O 3 , are not stable enough due formation lateral expansion defect...
Tris(2-chloroisopropyl) phosphate (TCPP), a widely used organophosphate flame retardant, has been recognized as an important atmospheric pollutant. It is notable that TCPP potential for long-range transport. However, its fate unknown, restricting environmental risk assessment. Herein we performed quantum chemical calculations to investigate the transformation mechanisms and kinetics of initiated by ·OH in presence O2/NO/NO2, effects ubiquitous water on these reactions. Results show...
Although substantial concerns about the inflammatory effects of engineered nanomaterial (ENM) have been raised, experimentally assessing toxicity various ENMs is challenging and time-consuming. Alternatively, quantitative structure-activity relationship (QSAR) models employed to assess nanosafety. However, no previous attempt has made predict potential ENMs.By employing metal oxide nanoparticles (MeONPs) as a model ENM, we aimed develop QSAR for prediction by their physicochemical...
Biofilm formation is a major threat to industry, the environment and human health. While killing of embedded microbes in biofilms may inevitably lead evolution antimicrobial resistance (AMR), catalytic quenching bacterial communications by lactonase promising antifouling approach. Given shortcomings protein enzymes, it attractive engineer synthetic materials mimic activity lactonase. Herein, an efficient lactonase-like Zn-Nx -C nanomaterial was synthesized tuning coordination around zinc...
The advancement of nanotechnology underscores the imperative need for establishing in silico predictive models to assess safety, particularly context chronic respiratory afflictions such as lung fibrosis, a pathogenic transformation that is irreversible. While compilation descriptors pivotal model development, key features specifically tailored predicting fibrosis remain elusive. This study aimed uncover essential governing nanoparticle-induced pulmonary fibrosis. We conducted comprehensive...
The wide uses of nanosilver (nAg) have resulted in concerns regarding ecotoxicity to aquatic organisms. Some previous studies found that the toxicity nAg is due nanoparticles themselves, while others ionic silver (Ag(+) ) released by particles plays an important role. In present study, authors quantitatively evaluated relative contribution and Ag(+) three organisms different trophic levels, including algal species (Raphidocelis subcapitata), a cladoceran (Chydorus sphaericus), freshwater...
Computational approaches are crucial to risk assessment and pollution prevention of newly synthesized compounds prior large-scale production commercialization. Understanding the kinetics mechanism tropospheric reaction semivolatile organic with ·OH is an indispensable component assessment. In this study, we show that density functional theory (DFT) can be successfully employed probe atmospheric photooxidation polybrominated diphenyl ethers (PBDEs) by ·OH, taking 4,4′-dibromodiphenyl ether...
Many Staphylococcus aureus have lost a major genetic barrier against phage infection, termed clustered regularly interspaced palindromic repeats (CRISPR/cas). Hence, S. strains frequently exchange material via phage-mediated horizontal gene transfer events, but, in turn, are vulnerable particular to lytic phages. Here, novel strategy of is described, which protects the activity Podoviridae, unique family staphylococcal phages with short, non-contractile tails. Unlike most phages, Podoviridae...
Despite the importance of phages in driving horizontal gene transfer (HGT) among pathogenic bacteria, underlying molecular mechanisms mediating phage adsorption to S. aureus are still unclear. Phage ϕ11 is a siphovirus with high transducing efficiency. Here, we show that tail protein Gp45 localized within baseplate. was efficiently neutralized by anti-Gp45 serum, and its host cells inhibited recombinant dose-dependent manner. Flow cytometry analysis demonstrated biotin-labelled stained...
BACKGROUND: Groundwater is a main drinking-water source for Chinese rural residents.The overall pollution status of organic micropollutants (OMPs) and metals in the groundwater corresponding health risks are unknown.OBJECTIVES: Our objective was to comprehensively screen assess OMPs areas China where used drinking so as provide benchmark monitoring improving quality future developments.METHODS: One hundred sixty-six samples were collected China, 1,300 25 screened by GC-MS, LC-QTOF/MS, ICP-MS...
Understanding the mechanism and thermodynamics of adsorption chemicals on carbon nanotubes (CNTs) is important to risk assessment pollution control both CNTs chemicals. We computed cyclohexane, benzene derivatives, polycyclic aromatic hydrocarbons (PAHs) (8,0) single-walled by M05-2X density functional theory. The energies (E(a)) in aqueous phase are lower than those gaseous phase, indicating that more favorable. contribution π-π interactions enhancing effect a -NO(2) substituent were...
Drought is a severe abiotic stress that affects global crop production. A drought model was created for 'Toyonoka' Fragaria <TEX>${\times}$</TEX> ananassa, and the effects of on contents proline, sugars, antioxidant enzyme activities were investigated. Strawberry transplants with identical growth chosen experiments randomized design included four replications (10 plants per block). The experimental sets differed in moisture level culture medium relative to range content as follows: control,...
Potential immune responses resulting from exposure to metal oxide nanoparticles (MeONPs) have been the subject of intensive discussion in last decade. Despite extensive use MeONPs several applications, their toxic effects on cells rarely predicted silico because complexity and complicated properties MeONPs. In present study, machine learning (ML) methods coupled with high-throughput vitro bioassays were used develop models for predicting toxicity cells. An ML model a high prediction accuracy...
Abstract Biofilm formation is a major threat to industry, the environment and human health. While killing of embedded microbes in biofilms may inevitably lead evolution antimicrobial resistance (AMR), catalytic quenching bacterial communications by lactonase promising antifouling approach. Given shortcomings protein enzymes, it attractive engineer synthetic materials mimic activity lactonase. Herein, an efficient lactonase‐like Zn−N x −C nanomaterial was synthesized tuning coordination...