A5010193265- Drug-Induced Hepatotoxicity and Protection
- Biochemical effects in animals
- Aldose Reductase and Taurine
- Heavy Metal Exposure and Toxicity
- Free Radicals and Antioxidants
- Pharmacological Effects and Toxicity Studies
- Liver Disease and Transplantation
- Medicinal Plants and Neuroprotection
- Sirtuins and Resveratrol in Medicine
- Bee Products Chemical Analysis
- Liver Disease Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Multiple Sclerosis Research Studies
- Reproductive Biology and Fertility
- Trace Elements in Health
- Neurological Complications and Syndromes
- Traditional Chinese Medicine Analysis
- Aluminum toxicity and tolerance in plants and animals
- Medicinal Plants and Bioactive Compounds
- Ovarian function and disorders
- Fluoride Effects and Removal
- Pomegranate: compositions and health benefits
- Selenium in Biological Systems
- Alcoholism and Thiamine Deficiency
- Chemotherapy-induced organ toxicity mitigation
Shiraz University of Medical Sciences
2016-2025
Shanxi Agricultural University
2019-2023
Ahvaz Jundishapur University of Medical Sciences
2015-2020
Hyperammonemia is associated with chronic and acute liver injury. There no promising therapeutic agent against ammonia-induced complications. Hence, finding molecules safe profile of administration has clinical value. The present study was conducted to evaluate the role taurine (TA) on plasma brain ammonia its consequent events in different models injury hyperammonemia. Bile duct ligated (BDL) rats were used as a model Thioacetamide acetaminophen-induced failure models. A high level detected...
Drug-induced kidney proximal tubular injury and renal failure (Fanconi syndrome; FS) is a clinical complication. Valproic acid (VPA) among the FS-inducing drugs. The current investigation was designed to evaluate role of mitochondrial dysfunction oxidative stress in VPA-induced injury.Animals received VPA (250 500 mg/kg, i.p., 15 consecutive days). Serum biomarkers markers were assessed. Moreover, mitochondria isolated indices, including succinate dehydrogenase activity (SDA),...
Sulfasalazine is a commonly used drug for the treatment of rheumatoid arthritis and inflammatory bowel disease. There are several cases renal injury encompass sulfasalazine administration in humans. The mechanism adverse effects toward kidneys obscure. Oxidative stress its consequences seem to play role sulfasalazine-induced injury. current investigation was designed investigate effect on kidney mitochondria. Rats received (400 600 mg/kg/day, oral) 14 consecutive days. Afterward,...
Lead (Pb) is a highly toxic heavy metal widely dispersed in the environment because of human industrial activities. Many studies revealed that Pb could adversely affect several organs, including male reproductive system. Pb-induced toxicity lead to infertility. Thus, finding safe and clinically applicable protective agents against this complication important. It has been found oxidative stress plays fundamental role pathogenesis reprotoxicity. Glycine simplest amino acid with wide range...
Introduction: Sodium benzoate (SB), as a chemical preservative, is used in many kinds of foodstuff. Some studies reported toxicity effects SB food products and suggested to limit its usage. The aim this study was evaluate the oral administration on antioxidant enzymes lipid peroxidation liver kidney mice. Materials Methods: A total 24 animals were divided into four groups: Control group three treated groups that received 150, 300, 600 mg/kg/day SB, respectively, drinking water for 4 weeks....
Fluoride (F) is capable of promoting abnormal proliferation and differentiation in primary cultured mouse osteoblasts (OB cells), although the underlying mechanism responsible remains rare. This study aimed to explore roles wingless INT-1 (Wnt) signaling pathways screen appropriate doses calcium (Ca2+) alleviate sodium fluoride (NaF)-induced OB cell toxicity. For this, we evaluated effect dickkopf-related protein 1 (DKK1) Ca2+ on mRNA levels wingless/integrated 3a (Wnt3a), low-density...
Hepatic encephalopathy (HE) is a neuropsychiatric syndrome ensuing from liver failure. The the major site of ammonia detoxification in human body. Hence, acute and chronic dysfunction can lead to hyperammonemia. Manganese (Mn) trace element incorporated several physiological processes Mn excreted through bile. It has been found that cirrhosis associated with hyperammonemia as well body accumulation. brain primary target organ for both toxicity. On other hand, mitochondria impairment involved...
Abstract Multiple sclerosis (MS) is a well‐known neurodegenerative disorder, causing toxicity in different organs, such as spinal cord tissue. The goal of this study was to investigate the protective effect ellagic acid (EA) against and sciatica function cuprizone (Cup)‐induced demyelination model. Animals were divided into six equal groups. first group received tap water control. Cup treated with (0.2% w/w fed). EA 100 orally (100 mg/kg). + groups three doses 5, 50, mg/kg plus w/w). All...
Background: Chloroquine and amodiaquine are used in the prophylaxis treatment of malaria. However, hepatic injury is associated with malaria drug therapy. On other hand, there no promising hepatoprotective agent for or antimalarial drugs‑induced liver injury. Carnosine a naturally occurring peptide pleiotropic protective properties different tissues. This investigation aimed to evaluate effect carnosine administration drugs-induced rats. Methods: Animals were treated (180 mg/kg, oral)...
Sodium benzoate (SB) is one of the food additives and preservatives that prevent growth fungi bacteria. SB has been shown to improve symptoms neurodegenerative disease such as Alzheimer's disease. The aim this study was evaluate effect on cell survival cellular antioxidant indices after exposure aluminum maltolate (Almal) in PC12 line a model neurotoxicity. cells exposed different concentrations (0.125 3 mg/mL) presence Almal (500 µM) viability, level reactive oxygen species (ROS),...
Abstract Cancer and diabetes, the two mitochondria‐related diseases, have recently been linked to silent mating‐type information regulation 2 homolog 3 (SIRT3) activity irregularities. In this study, effect of metformin, an antidiabetic with anticancer properties, has evaluated on mitochondrial functionality markers, cell death pathways, SIRT3 enzyme in colon cancer line, HT‐29, human embryonic kidney cells (HEK 293). HT‐29 were treated metformin (5, 10, 20, 40, 80 µM) for 24, 48, 72 h...
Background: Teucrium Polium and Prosopis Farcta have been traditionally employed in cancer treatment. In this study we evaluated the effects of methanolic extracts these two plants HT-29 cells. Methods: IC50s were obtained via MTT assay levels ROS production, cell death, collapse mitochondrial membrane potential Sirt3 enzyme activity determined. Results: After 48 hours exposure, for 3 2μg/ml, respectively. Extracts induced higher production after 6 than 12 hours. Mitochondrial death rate...
Background: Propylthiouracil (PTU) administration is associated with several cases of hepatotoxicity, especially in children. The mechanism(s) PTU-induced hepatotoxicity obscure. In the current study, we aimed to assess effect PTU on hepatocytes mitochondria different experimental models. Methods: Mice were treated (10, 20, 40, 80, and 100 mg/kg, i.p) then, liver isolated evaluated. Moreover, from normal mice incubated increasing concentrations (10 µM-1 mM). Mitochondrial dehydrogenases...
Paraquat (PQ) has accounted for numerous suicide attempts in developing countries. Aspirin (ASA) as an adjuvant treatment PQ poisoning ameliorative role. And, it's uncoupling of mitochondrial oxidative phosphorylation role been well established. The current study aimed at examining the aspirin mechanism on lung mitochondria rats exposed to PQ. Male were randomly allocated five groups: Control group, group (50 mg/kg; orally, only first day), and + ASA (100, 200, 400 i.p.) groups 3 weeks....
Background: Endocrine conditions that impact women define polycystic ovary syndrome. Previous studies have demonstrated a connection between PCOS and insulin intolerance, oxidative stress, immune system dysfunction. Additionally, some reports indicated propolis has antioxidant properties chitosan nanoparticles beneficial effects on the reproductive system. The goal of present study is to compare metformin (Met) chitosan-propolis explain how they protect against rat model caused by estradiol...