A5059208997- Aluminum toxicity and tolerance in plants and animals
- Genomic variations and chromosomal abnormalities
- Medicinal Plants and Neuroprotection
- Prenatal Screening and Diagnostics
- Protein Hydrolysis and Bioactive Peptides
- Medicinal Plants and Bioactive Compounds
- Seaweed-derived Bioactive Compounds
- Biomarkers in Disease Mechanisms
- Hemoglobinopathies and Related Disorders
- Phytochemical and Pharmacological Studies
- Protease and Inhibitor Mechanisms
- Peptidase Inhibition and Analysis
- Marine Sponges and Natural Products
- Ginseng Biological Effects and Applications
- Alzheimer's disease research and treatments
- S100 Proteins and Annexins
- Vitamin C and Antioxidants Research
- Anesthesia and Neurotoxicity Research
- Cancer-related gene regulation
- Heavy Metal Exposure and Toxicity
- Heme Oxygenase-1 and Carbon Monoxide
- Chromosomal and Genetic Variations
- Forensic and Genetic Research
- Cancer Mechanisms and Therapy
- Curcumin's Biomedical Applications
Shiraz University of Medical Sciences
2016-2024
Sodium benzoate (SB) is one of the food additives and preservatives that prevent growth fungi bacteria. SB has been shown to improve symptoms neurodegenerative disease such as Alzheimer's disease. The aim this study was evaluate effect on cell survival cellular antioxidant indices after exposure aluminum maltolate (Almal) in PC12 line a model neurotoxicity. cells exposed different concentrations (0.125 3 mg/mL) presence Almal (500 µM) viability, level reactive oxygen species (ROS),...
Aluminum (Al) exposure is among the environmental risk factors that may involve in pathogenesis of neurodegenerative diseases. Oxidative stress has a critical role Al-induced toxicity. Saffron plant with potent radical scavenging and anti-oxidative properties. This investigation was designed to evaluate possible protective effects saffron extract (SE) on aluminum maltolate (Almal)-induced oxidative apoptosis PC12 cell line.In this vitro study, cells were divided into four groups including...
According to recent studies, valproate shows some protection against oxidative stress (OS) induced by neurotoxins. Current investigation tried determine the possible ameliorating effects of sodium (SV) aluminum (Al)-induced cell death, apoptosis, mitochondrial membrane potential (MMP), and OS in PC12 cells.In this vitro study, cells were treated with different concentrations maltolate (Almal) without SV (50-400 µM). Cell viability was assessed MTT assay. To measure quantitatively on...
Background: Sodium benzoate, a food preservative, prevents the growth of fungi and bacteria. Numerous studies have reported protective effects sodium benzoate on nervous system. This study investigated effect cell apoptosis mitochondrial function in an aluminum toxicity model. Methods: After 48 hr treating PC-12 cells with varying concentrations (0.125, 0.25 or 0.5 mg/ml) presence maltolate (500 μM), viability was assessed by MTT assay. The type death (necrosis apoptosis) analyzed flow...
Epithelial-to-mesenchymal transition (EMT) plays a critical role in colorectal cancer (CRC) metastasis. In the present study, we evaluated effects of annexin A5 (ANXA5) overexpression on invasiveness as well expression genes involved EMT HCT 116 cell line. PCMV6-AC-IRES-GFP plasmid harboring ANXA5 cDNA was constructed. line transfected with recombinant plasmids using Lipofectamine 3000. Fluorescent microscopy used to determine efficiency transfection. Cell viability determined MTT assay....
Quantitative fluorescent polymerase chain reaction (QF-PCR), in recent years, has been accepted as a rapid, high throughput, and sensitive method for prenatal diagnosis of common chromosomal aneuploidies. Since short tandem repeats (STRs) are the cornerstone QF-PCR technique, selection most polymorphic STR markers is an essential step successful assay. The genetic variation parameters each marker differ among different populations. In this study, we investigated size, frequency,...
Background: Gilbert’s syndrome can present as a chronic or benign asymptomatic condition, characterized by slight increase in the serum bilirubin level without any hemolysis. In 1995, genetic variation, located TATA box of UGT1A1 gene promoter, was identified patients with syndrome. Also, further analysis new missense Gly71Arg, within codon region gene. Coincidence and Gly71Arg variations their relationship clinical findings are mostly variable. Objectives: The aim this study to determine...
Abstract Background It is believed that loss of p53 function plays a crucial role in the progression well to poorly differentiated thyroid cancers including anaplastic carcinoma (ATC). Given poor prognosis ATC due its strong therapeutic resistance, there need establish new targets extend survival patients. Activating transcription factor 3 (ATF3) can inhibit oncogenic activity mutant and, as result, contribute tumor suppression several TP53-mutated cancers. Herein, we demonstrate ectopic...