A5061907191- Drug-Induced Hepatotoxicity and Protection
- Aldose Reductase and Taurine
- Biochemical effects in animals
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Free Radicals and Antioxidants
- Alcoholism and Thiamine Deficiency
- Chemotherapy-induced organ toxicity mitigation
- Drug Transport and Resistance Mechanisms
- Mitochondrial Function and Pathology
- Prenatal Substance Exposure Effects
- Pharmacogenetics and Drug Metabolism
- Trace Elements in Health
- Pesticide Exposure and Toxicity
- Neuroscience and Neuropharmacology Research
- Vitamin C and Antioxidants Research
- Alcohol Consumption and Health Effects
- Computational Drug Discovery Methods
- Antibiotics Pharmacokinetics and Efficacy
- Cancer, Lipids, and Metabolism
- Heavy Metals in Plants
- Garlic and Onion Studies
- Ginger and Zingiberaceae research
- Histone Deacetylase Inhibitors Research
- Milk Quality and Mastitis in Dairy Cows
Ferdowsi University of Mashhad
2025
Ministry of Health and Medical Education
2016-2024
Iran Nanohealth Committee Food and Drug Organization
2014-2024
Tabriz University of Medical Sciences
2013-2015
Biotechnology Research Center
2013-2014
Tehran University of Medical Sciences
2001
Hyperammonemia is associated with chronic and acute liver injury. There no promising therapeutic agent against ammonia-induced complications. Hence, finding molecules safe profile of administration has clinical value. The present study was conducted to evaluate the role taurine (TA) on plasma brain ammonia its consequent events in different models injury hyperammonemia. Bile duct ligated (BDL) rats were used as a model Thioacetamide acetaminophen-induced failure models. A high level detected...
Considering the importance of onions consumption in household diet, controlling heavy elements' concentration foodstuffs is important to ensure safety an individual's health. This study aimed evaluate risk metals through onion on human In this cross-sectional experimental study, 22 samples with varieties red, yellow, and white two autumn winter seasons 2020 were randomly collected from different provinces Kurdistan, Hamedan, Kermanshah. The concentrations evaluated atomic absorption...
Sulfasalazine is a commonly used drug for the treatment of rheumatoid arthritis and inflammatory bowel disease. There are several cases renal injury encompass sulfasalazine administration in humans. The mechanism adverse effects toward kidneys obscure. Oxidative stress its consequences seem to play role sulfasalazine-induced injury. current investigation was designed investigate effect on kidney mitochondria. Rats received (400 600 mg/kg/day, oral) 14 consecutive days. Afterward,...
ABSTRACT Statins are potent drugs, used as lipid‐lowering agents in cardiovascular diseases. Hepatotoxicity is one of the serious adverse effects statins, and exact mechanism hepatotoxicity not yet clear. In this study, cytotoxic most commonly that is, atorvastatin, lovastatin, simvastatin toward isolated rat hepatocytes, were evaluated. Markers, such cell death, reactive oxygen species (ROS) formation, lipid peroxidation, mitochondrial membrane potential, amount reduced oxidized glutathione...
Objective(s): Manganese (Mn) is an essential trace element physiologically incorporated in the structure of several vital enzymes. Despite its essentiality, excessive Mn exposure toxic with brain tissue as primary target organ. There no specific and clinically available therapeutic/preventive option against neurotoxicity. Carnosine a neuropeptide physiological roles. The neuroprotective properties this peptide have been evaluated different experimental models. current study was designed to...
ABSTRACT Aminoglycoside antibiotics are widely used against Gram‐negative infections. On the other hand, nephrotoxicity is a deleterious side effect associated with aminoglycoside therapy. Gentamicin most nephrotoxic aminoglycoside. Because of serious health complications ensue induced by aminoglycosides, finding new therapeutic strategies this problem has great clinical value. This study attempted to compare properties gentamicin and nanosized formulation drug in mice model. Animals were...
Background Proline is a proteinogenic amino acid with multiple biological functions. Several investigations have been supposed that cellular proline accumulation stress response mechanism. This acts as an osmoregulator, scavenges free radical species, boosts antioxidant defense mechanisms, protects mitochondria, and promotes energy production. The current study was designed to investigate the effect of treatment on liver in bile duct ligated (BDL) rats animal model cholestasis/cirrhosis....
Lead (Pb) is a highly toxic heavy metal widely dispersed in the environment because of human industrial activities. Many studies revealed that Pb could adversely affect several organs, including male reproductive system. Pb-induced toxicity lead to infertility. Thus, finding safe and clinically applicable protective agents against this complication important. It has been found oxidative stress plays fundamental role pathogenesis reprotoxicity. Glycine simplest amino acid with wide range...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Abdoli N, Sadeghian I, Azarpira Ommati M, Heidari R. Taurine mitigates bile duct obstruction-associated cholemic nephropathy: effect on oxidative stress and mitochondrial parameters. Clinical Experimental Hepatology. 2021;7(1):30-40. doi:10.5114/ceh.2021.104675. APA Abdoli, N., Sadeghian, I., Azarpira, Ommati, M., & Heidari, (2021). Hepatology, 7(1), 30-40. https://doi.org/10.5114/ceh.2021.104675 Chicago...
Imatinib is a tyrosine kinase inhibitor widely administered against chronic myeloid leukemia. On the other hand, drug-induced kidney proximal tubular injury, electrolytes disturbances, and renal failure clinical complication associated with imatinib therapy. There no precise cellular mechanism(s) for imatinib-induced injury. The current investigation aimed to evaluate role of mitochondrial dysfunction oxidative stress in pathogenesis nephrotoxicity. Rats received (50 100 mg/kg, oral, 14...
Hepatic encephalopathy (HE) is a serious clinical complication, which could lead to coma and death if not appropriately managed. There agreement on the predominant role of ammonia in etiology HE. Brain one most critical organs affected by ammonia. The oxidative stress its consequences pathogenesis ammonia-induced brain injury have been revealed before. On other hand, there no promising therapeutic option against neurotoxicity. Taurine abundant amino acids human body. Several pharmacological...
Cirrhosis-induced renal injury or cholemic nephropathy (CN) is a serious clinical complication with poor prognosis. CN could finally lead to failure and the need for organ transplantation. Unfortunately, there no specific pharmacological intervention against date. On other hand, various studies mentioned role of oxidative stress mitochondrial impairment in pathogenesis CN. The current study aimed evaluate potential protective effects NAC as thiol-reducing agent antioxidant Bile duct ligation...