A5035784439- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Drug-Induced Hepatotoxicity and Protection
- Drug Transport and Resistance Mechanisms
- Heavy Metal Exposure and Toxicity
- Aldose Reductase and Taurine
- Prenatal Substance Exposure Effects
- Cancer Mechanisms and Therapy
- Inflammasome and immune disorders
- Biochemical effects in animals
- Heavy Metals in Plants
- Electrolyte and hormonal disorders
- Polymer crystallization and properties
- Chemotherapy-induced organ toxicity mitigation
- Metabolism and Genetic Disorders
- Muscle and Compartmental Disorders
- Effects of Radiation Exposure
- Mesenchymal stem cell research
- Polymer Science and PVC
- Craniofacial Disorders and Treatments
- Histone Deacetylase Inhibitors Research
- Inflammatory Biomarkers in Disease Prognosis
- Menstrual Health and Disorders
- Hibiscus Plant Research Studies
- Neurological Disorders and Treatments
Lorestan University of Medical Sciences
2019-2025
Shahid Sadoughi University of Medical Sciences and Health Services
2024
Shiraz University of Medical Sciences
2012-2021
Shiraz University
2019
Yasuj University of Medical Sciences
2019
Shahid Beheshti University of Medical Sciences
2017-2018
Tehran University of Medical Sciences
2016
Mazandaran University of Medical Sciences
2016
Smokeless tobacco (ST) products create a deadly combination of addiction to nicotine and exposure toxic substances. Nass is the predominant smokeless product consumed in Iran. This study was conducted evaluate levels arsenic (As), lead (Pb), nickel (Ni), cadmium (Cd) brands available Iranian market. A total 42 samples were analyzed for heavy metals using flame atomic absorption spectrometry. The also evaluated risk associated with carcinogenic non-carcinogenic metal contamination level...
Background Proline is a proteinogenic amino acid with multiple biological functions. Several investigations have been supposed that cellular proline accumulation stress response mechanism. This acts as an osmoregulator, scavenges free radical species, boosts antioxidant defense mechanisms, protects mitochondria, and promotes energy production. The current study was designed to investigate the effect of treatment on liver in bile duct ligated (BDL) rats animal model cholestasis/cirrhosis....
Cirrhosis-induced heart injury and cardiomyopathy is a serious consequence of this disease. It has been shown that bile duct ligated (BDL) animals could serve as an appropriate experimental model to investigate tissue in cirrhosis. The accumulation cytotoxic chemicals (e.g., acids) also adversely affect the tissue. Oxidative stress mitochondrial impairment are most prominent mechanisms acid cytotoxicity. Taurine (Tau) abundant non-protein amino human body. cardioprotective effects have...
We decided to investigate the antileishmanial, cellular mechanisms, and cytotoxic effects of green synthesized Zinc nanoparticles (ZnNPs) alone combined with glucantime against Leishmania major infection.The effect ZnNP on L. amastigote was studied through macrophage cells. The mRNA expression level iNOS IFN-γ followed by exposure J774-A1 cells ZnNPs assessed Real-time PCR. Caspase-3-like activity promastigotes exposed studied. Effects (MA) were cutaneous leishmaniasis in BALB/c mice.ZnNPs...
It has been well documented that cirrhosis is associated with the intestinal injury. Intestinal injury in could lead to bacterial lipopolysaccharide (LPS) translocation systemic circulation. found high plasma LPS connected higher morbidity and mortality cirrhotic patients. Therefore, finding therapeutic approaches mitigate this complication great clinical value. Several investigations mentioned pivotal role of oxidative stress cirrhosis-associated well-known redox balance enterocytes...
Imatinib is a tyrosine kinase inhibitor widely administered against chronic myeloid leukemia. On the other hand, drug-induced kidney proximal tubular injury, electrolytes disturbances, and renal failure clinical complication associated with imatinib therapy. There no precise cellular mechanism(s) for imatinib-induced injury. The current investigation aimed to evaluate role of mitochondrial dysfunction oxidative stress in pathogenesis nephrotoxicity. Rats received (50 100 mg/kg, oral, 14...
Cholestasis-associated renal injury or cholemic nephropathy (CN) is a serious clinical problem. Previous studies mentioned that oxidative stress and mitochondrial impairment play role in CN. There no specific pharmacological intervention for Metformin an anti-diabetic drug administered decades. On the other hand, novel properties have emerged this drug. The effect of metformin on parameters has been well-recognized different experimental models. It also found positively affected function....
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Mohammadi H, Sayad A, M, Niknahad Heidari R. N-acetyl cysteine treatment preserves mitochondrial indices of functionality in the brain hyperammonemic mice. Clinical and Experimental Hepatology. 2020;6(2):106-115. doi:10.5114/ceh.2020.95814. APA Mohammadi, H., Sayad, A., M., Niknahad, & Heidari, (2020). Hepatology, 6(2), 106-115. https://doi.org/10.5114/ceh.2020.95814 Chicago Hamidreza, Abolfazl Mohsen Hossein...
Purpose: Hepatic encephalopathy (HE) is a critical situation in which liver failure affects brain function. HE could result state of coma and death. The the main organ for ammonium ion (NH 4 + ) metabolism. Hence, acute and/or chronic lead to hyperammonemia. NH most suspected neurotoxic agent HE. Thus, finding new therapeutic options decrease plasma levels has significant clinical value. Mesoporous silica (MS) particles have revolutionized many aspects pharmaceutical sciences, including drug...
Abstract Background Ifosfamide (IFO) is an alkylating agent administered against different types of malignancies. Several cases renal injury and serum electrolytes disturbances have been reported in IFO-treated patients. Oxidative stress mitochondrial dysfunction are suspected being involved the mechanism IFO nephrotoxicity. Carnosine a dipeptide which its antioxidant mitochondria protecting properties mentioned experimental models. The current study aimed to evaluate nephroprotective...
Melanin is a group of natural pigments that determines the human skin color and provides fundamental protection against harmful impacts physical chemical stimuli. The aim this study was to establish regulatory role aryl hydrocarbon receptor (AhR) in α-melanocyte-stimulating hormone (α-MSH) induced melanogenesis. In present study, following knockdown AhR, murine B16F10 cells were treated with α-MSH (200 nM) tyrosinase activities, cellular melanin content, mRNA levels several important genes...
Abstract The aim of this study was the identification luteolin in Prosopis farcta extract (PFE) and melatonin to evaluate its effect on THC withdrawal syndrome mice. Luteolin identified by high‐performance liquid chromatography (HPCL). Signs toxicity mice PFE were monitored for LD50 calculation. behavioral symptoms (stereotypies, ambulation, inactivity time) induced rimonabant challenge illustrated THC‐dependent receiving PFE, luteolin, melatonin. expression mature BDNF (mBDNF) evaluated...
Heavy metals are environmental pollutants which pose toxicity toward biological systems. Most organs susceptible to heavy metals-induced toxicity. Hence, finding protective agents against is valuable. The post-nuclear supernatant (PNS) has been accepted as an in vitro model for assessing xenobiotic-induced Monitoring the toxic effects of a large number xenobiotics short time one superiorities PNS system. goal present study was validate investigating effect (Cd, Co, Cu, Fe, As, Hg, Cr, and...
Taurine (TAU) is the most abundant free amino acid in human body. High concentrations of this are found tissues such as skeletal muscle, brain, and kidney. Recently, a focus has emerged on effects TAU cellular mitochondria. It been that could positively affect organelle by enhancing mitochondrial membrane potential, increasing ATP levels, mitigating mitochondria-mediated ROS formation. The current study aimed to evaluate effect wide range (0.01 mM-1000 mM) function. Mice liver mitochondria...
Microbial exopolysaccharides have recently served as an efficient substrate for the production of biocompatible metal nanoparticles given their favorable stabilizing and reducing properties properties.