A5046751956- Cervical Cancer and HPV Research
- Viral-associated cancers and disorders
- Respiratory viral infections research
- Herpesvirus Infections and Treatments
- Cytomegalovirus and herpesvirus research
- T-cell and Retrovirus Studies
- MicroRNA in disease regulation
- Chromosomal and Genetic Variations
- Animal Virus Infections Studies
- Cancer-related molecular mechanisms research
- Viral gastroenteritis research and epidemiology
- Circular RNAs in diseases
- Virus-based gene therapy research
- Viral Infections and Vectors
- Congenital Diaphragmatic Hernia Studies
- Genital Health and Disease
- Viral Infections and Immunology Research
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- TGF-β signaling in diseases
- Cancer-related gene regulation
- Cancer Research and Treatments
- RNA modifications and cancer
- Sperm and Testicular Function
- Toxin Mechanisms and Immunotoxins
Shahid Beheshti University of Medical Sciences
2016-2024
Weatherford College
2019
GTx (United States)
2018
Tehran University of Medical Sciences
2011-2016
The nuclear factor erythroid 2 related (Nrf2) is a major regulator of intracellular inducible defense systems against harmful endogenous and exogenous substances in the body. Under normal conditions Nrf2 mainly binds to keap1 located cytoplasm. However, response oxidative electrophile stress, translocated nucleus link anti‐oxidant elements induce transcription cytoprotective genes. Most viruses cause stress increase activity radicals reactive oxygen species (ROS), subsequently, cellular...
Colorectal cancer (CRC) is one of the most common cancers and a major cause cancer-related death worldwide. The early diagnosis colorectal tumors important challenges in management. MicroRNAs (miRNAs) have provided new insight into CRC development been suggested as reliable stable biomarkers for prognosis. This study's objective was to analyze differential expression miRNAs at differentstages searching possible correlation with clinicopathological features examine their potential value...
Abstract Background Finding new biomarkers for the early detection of cervical cancer is an essential requirement in this field. In study, we aimed to evaluate expression level potential progression patients with compared normal subjects. Methods The levels tissue and serum miRNAs, including miR-9, miR-192 miR-205, were investigated 36 normal, 18 precancer, samples using real-time polymerase chain reaction. Results results showed higher significant expressions miR-205 than those samples....
Breast cancer is one of the most common health problems. It has been suggested that several risk factors, either considered as external or internal, play a critical role in pathogenesis breast cancer, which among them, HERV-k, fundamental role. In present study, we aimed to evaluate HERV-k env, gag, rec, np9 expressions progression.We collected 40 tissues and their normal adjacent ones. After extracting RNA samples, evaluated expression by using Quantitative real-time PCR (qRT-PCR).The...
Breast cancer (BC) is the most common malignancy affecting females worldwide. Various risk factors play a role in developing of BC. Infectious agents like viruses have been proposed for this and Epstein-Barr virus (EBV) widely researched candidate virus. This study detects presence EBV-DNA breast patients.The was conducted on 59 formalin-fixed paraffin-embedded (FFPE) tissue blocks samples women with carcinoma 11 non-neoplastic controls. The DNA extracted all samples. Then detection EBNA1...
Abstract Background The role of viruses as a cause breast cancer (BC) has been significantly investigated in recent years. Human papillomavirus (HPV) detected invasive carcinomas, while most studies have only focused on the detection viral DNA, we aimed to examine prevalence and genotypes HPV among Iranian BC patients. We also examined presence herpes simplex-1 (HSV-1), simplex-2 (HSV-2), varicella zoster virus (VZV), cytomegalovirus (CMV) these samples. Methods collected analyzed 70...
Given the global outbreak of breast cancer and its debilitating effect on women's health, it is not surprising that tremendous efforts have been made with an aim shedding more light mechanisms involved in pathogenesis this type cancer. Among long list risk factors associated malignancy, recently, role microRNAs (miRNAs or miRs) has turned into a hotspot for investigations. miRNAs approximately 20 nucleotides length are located either exon intron, playing regulation gene expression. In...
Background: Nisin is a potent bacteriocin produced by Lactococcus lactis subsp. and anti bacterial peptide. Colorectal cancer (CRC) considered as one of the most prevalent mortal cancers throughout world. Genetic variations environmental factors are responsible for initiation development cancer. Regulation apoptosis process plays an important role in crc. bax, bcl2, caspase 3, 6, 8 9 genes involved induction apoptosis. Objectives: The present study describes cytotoxic effects nisin gene...
Colorectal cancer (CRC) is a notable cause of cancer‑associated mortality worldwide, making it pertinent topic for the study and its treatment. Staphylococcal enterotoxin B (SEB), an produced by Staphylococcus aureus, has been demonstrated to exert anticancer antimetastatic effects due ability modify cell immunity cellular signaling pathways. In current study, SEB was investigated, including whether exerts growth inhibitory on colon adenocarcinoma cells. This may occur through manipulation...