A5010467917- Bone Tumor Diagnosis and Treatments
- Sarcoma Diagnosis and Treatment
- Musculoskeletal synovial abnormalities and treatments
- Bone and Joint Diseases
- Orthopedic Surgery and Rehabilitation
- Orthopaedic implants and arthroplasty
- Oral and Maxillofacial Pathology
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Bone health and osteoporosis research
- Cancer Cells and Metastasis
- Elbow and Forearm Trauma Treatment
- Hip and Femur Fractures
- Radiopharmaceutical Chemistry and Applications
- Bone fractures and treatments
- Bone health and treatments
- Shoulder Injury and Treatment
- Knee injuries and reconstruction techniques
- Cancer-related molecular mechanisms research
- Orthopedic Infections and Treatments
- Shoulder and Clavicle Injuries
- Cardiac tumors and thrombi
- Total Knee Arthroplasty Outcomes
- Cancer Genomics and Diagnostics
- Inflammatory Bowel Disease
- Osteoarthritis Treatment and Mechanisms
Iran University of Medical Sciences
2016-2025
University of Minnesota
2024-2025
University of Minnesota System
2025
Masonic Cancer Center
2024
Lorestan University of Medical Sciences
2021-2024
ORCID
2024
Tehran University of Medical Sciences
2015-2023
Shariati Hospital
2019-2023
ICT Research Institute
2023
Islamic Azad University Medical Branch of Tehran
2022
Abstract Long noncoding RNAs (lncRNAs) have been demonstrated to regulate a variety of cell processes and involve in the development progression colorectal cancer (CRC). Recently, circulating lncRNAs emerged as minimally invasive biomarkers for diagnosis prognosis. We aimed examine plasma expression level long lnc‐ATB, lnc‐CCAT1, lnc‐OCC‐1 CRC patients evaluate clinical values. A total 74 pretreatment healthy blood biopsies were subjected differentially levels three (OCC‐1, CCAT1, ATB)....
Colorectal cancer (CRC) is one of the most common cancers and a major cause cancer-related death worldwide. The early diagnosis colorectal tumors important challenges in management. MicroRNAs (miRNAs) have provided new insight into CRC development been suggested as reliable stable biomarkers for prognosis. This study's objective was to analyze differential expression miRNAs at differentstages searching possible correlation with clinicopathological features examine their potential value...
Aim: There is no consensus regarding the clinical significance of CD44 and CD24 as cancer stem cell (CSC) marker in colorectal (CRC). Methodology: A total 494 CRC samples (2008–2017) were assessed for (epithelial isoform) expression using tissue microarray. Results: individually or combination with was not associated any clinicopathologic characteristics tumor. inversely pathological Tumor, Node, Metastasis (pTNM) lower stages (p = 0.038) lymphatic invasion 0.05). Conclusion: In summary,...
Primary malignant tumors of the proximal femur in children are rare, and there is no consensus about optimal reconstruction method for this condition. While methods biological reconstruction-such as vascularized fibular allograft rotationplasty-and nonbiological options like expandable endoprosthesis exist reconstructive choices, each has its distinct advantages disadvantages. In study, we compared outcomes osteoarticular (OAA) with allograft-prosthetic component (APC) reconstructing a...
Cancer stem cell (CSC) markers have attracted considerable attention in tumor diagnostic, prognostic, and therapeutic implications. Detection of cancer cells circulating blood using has received remarkable recently. In this study, we aimed to investigate the messenger RNA (mRNA) expression level Lgr5 DCLK1 as most proposed colorectal CSC circulation also determine subsequent association patients' clinical pathological findings. Peripheral mononuclear (PBMCs) 58 patients with at stage I-IV 33...
The Scutellaria species (Lamiaceae) is used as a source of flavonoids to treat variety diseases in traditional medicine. In spite many reports about the cytotoxic and antitumor effects some this genus, anticancer researches on one Iranian S. litwinowii have not yet been conducted. properties total methanol extract its fractions were investigated different cancer cell lines including AGS, HeLa, MCF-7, PC12 NIH 3T3. Meanwhile, role apoptosis toxicity was explored. cells cultured DMEM medium...
Effects of vitamin D optimization on quality life patients with fibromyalgia: A randomized controlled trial
BACKGROUND: DCLK1, as the most potential colorectal cancer stem cell (CSC) marker has been core of many recent investigations. However, no study performed to evaluate circulating cellular DCLK1 protein (CCDP) that might reflect presences CSC in circulation. OBJEC TIVES: We aimed CCDP peripheral blood mononuclear cells (PBMCs) (CRC) patients applying immunoassay based methods including PLA, IPCR and ELISA order introduce method choice for clinical detection CCDP. METHODS: PBMCs were extracted...
The status of the local and circulating SOX9, a master regulator tumor fate, its relevance to types, severity, invasion feature, response therapy, chemotherapy treatment were surveyed in bone cancer current study.The SOX9 expression level was evaluated tissue peripheral blood mononuclear cells from patients with different types malignant benign tumors also margin tissues using Real-Time PCR. protein assessed immunohistochemistry western blot analysis. Also, correlations patient's clinical...
Machine learning (ML) has shown exceptional promise in various domains of medical research. However, its application predicting subsequent fragility fractures is still largely unknown. In this study, we aim to evaluate the predictive power different ML algorithms area and identify key features associated with risk osteoporotic patients.
Predicting the response of inflammatory bowel disease (IBD) patients to infliximab (IFX) is an unmet clinical need. The expression and density transmembrane tumor necrosis factor-α in circulating leukocytes maybe directly related by promoting apoptosis.We tested hypothesis that direct apoptosis assessment real-time polymerase chain reaction evaluation pro-apoptotic (Bax) anti-apoptotic (Bcl-2) proteins peripheral blood mononuclear cells (PBMCs) might be associated with IFX.IFX naïve (Crohn's...
Aims The crucial role of the radial head in stability elbow terrible triad injury is acknowledged. This retrospective study aims to compare results resection a severely comminuted with or without prosthetic arthroplasty as part reconstruction for this injury. Patients and Methods outcome was compared 29 15 patients injuries, respectively. There were ten female (34.5%) group six (40%) prosthesis group. mean age 40.7 years (sd 13.6) 36 9.4) follow-up 24.4 months 12) 45.8 6.8) Outcome measures...
Giant cell tumours (GCTs) of the proximal femur are rare, and there is no consensus about best method filling defect left by curettage. In this study, we compared outcome using a fibular strut allograft bone cement to reconstruct after extended curettage GCT femur.In retrospective reviewed 26 patients with in whom had been filled either (n = 12) or 14). Their demographic details oncological nononcological complications were retrieved from their medical records. Limb function was assessed...
Cancer stem cell (CSC) markers could serve as potential prognostic procedure. This study is aimed to investigate the local expression of doublecortin-like kinase 1 (DCLK1) and Lgr5 in colorectal cancer tissues (CRC) at both protein messenger RNA (mRNA) level, followed by providing a comparison circulating pattern these markers, based on our present previous study. The mRNA level DCLK1 was evaluated using comparative real-time PCR method applying 58 fresh tumor their correspondent normal...
OBJECTIVES: Anti-tumor necrosis factor (TNF)-α agents like Infliximab (IFX) are effective in the treatment of inflammatory bowel diseases (IBDs) and widely used. However, a considerable number patients do not respond or lose response to this therapy. Preliminary evidence suggests that transmembrane TNF-α (tmTNF-α) might be linked IFX by promoting reverse signaling-induced apoptosis cells. The main aim study was evaluation hypothesis primary non-responders. METHODS: A total 47 naive IBD were...
This study is aimed to unravel the status of local and circulating β-catenin in different primary bone tumors its relevance tumor types, severity, chemotherapy. The mRNA expression level protein (intensity level) were evaluated tissue peripheral blood mononuclear cells 150 patients with types (78 malignant 72 benign tumors) using Real-Time PCR immunohistochemistry. increased which was positively correlated malignancy. Amongst osteosarcoma, Ewing's Sarcoma, chondrosarcoma, osteochondroma,...