A5042704518- Renal cell carcinoma treatment
- Epigenetics and DNA Methylation
- Renal and related cancers
- Ferroptosis and cancer prognosis
- Solar Thermal and Photovoltaic Systems
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Immunotherapy and Biomarkers
- Bladder and Urothelial Cancer Treatments
- Venous Thromboembolism Diagnosis and Management
- Photovoltaic System Optimization Techniques
- Solar-Powered Water Purification Methods
- Cancer, Hypoxia, and Metabolism
- Electrical and Bioimpedance Tomography
- Mechanical Engineering and Vibrations Research
- Solar Radiation and Photovoltaics
- Aerodynamics and Fluid Dynamics Research
- Palliative Care and End-of-Life Issues
- Urinary and Genital Oncology Studies
- Cancer-related gene regulation
- Disaster Response and Management
- Heat Transfer and Optimization
- Vehicle Dynamics and Control Systems
- Heat Transfer Mechanisms
- Spectroscopy Techniques in Biomedical and Chemical Research
- Mineral Processing and Grinding
PLA Academy of Military Science
2021-2024
Chinese PLA General Hospital
2021-2024
Nanjing University of Chinese Medicine
2024
State Key Laboratory of Kidney Diseases
2022
Chinese People's Liberation Army
2022
Nankai University
2021
Union Hospital
2020
Huazhong University of Science and Technology
2017-2020
m6A modification has been studied in tumors, but its role host anti-tumor immune response and TAMs polarization remains unclear. The fatty acid oxidation (FAO) process of is also attracting attention. A co-culture model colorectal cancer (CRC) cells macrophages was used to simulate the tumor microenvironment. Expression changes demethylase genes FTO ALKBH5 were screened. further investigated. Gain-of-function experiments conducted study ALKBH5's effects on macrophage M2 polarization, CRC...
Previous studies have suggested that patients with cancer may be at an increased risk of death from unintentional injury, but to our knowledge, no large examined the rates injury among cancer.To characterize incidence in United States.This retrospective cohort study included diagnosed a first primary between January 1, 1973, and December 31, 2015, identified Surveillance, Epidemiology, End Results (SEER) program data. Comparisons general US population were based on mortality data collected...
Ferredoxin 1 (FDX1), an iron-sulphur protein, is responsible for electron transfer in a range of metabolic redox reactions. Clear cell renal carcinoma (ccRCC) aggressive cancer characterised by reprogramming, and FDX1 critical regulator cuproptosis. However, the expression profile prognostic value associated with clinicopathological features ccRCC remain largely unelucidated. In this study, we integrated series public bioinformatic analysis to explore mRNA protein profiles across human...
Abstract Xp11.2 translocation renal cell carcinomas (tRCC) are a rare and highly malignant type of cancer, lacking efficient diagnostic indicators therapeutic targets. Through the analysis public databases our cohort, we identified NMRK2 as potential marker for distinguishing tRCC from kidney clear carcinoma (KIRC) papillary (KIRP) due to its specific upregulation in tissues. Mechanistically, discovered that TFE3 fusion protein binds promoter gene, leading upregulation. Importantly,...
Cell division cycle‑associated 5 (CDCA5) protein, which is involved in cohesion, contributes to cell cycle regulation and chromosome segregation by maintaining genomic stability. Accumulating evidence indicates that CDCA5 expression upregulated a number of types cancer associated with poor prognosis. However, the biological function clear renal carcinoma (ccRCC) remains largely unknown. In present study, The Cancer Genome Atlas data mining revealed was more highly expressed ccRCC than...
Clear cell renal carcinoma (ccRCC), which is the most prevalent subtype, has a poor prognosis. Emerging strategies for enhancing immune response in ccRCC therapy are currently being investigated. Fibrinogen-like Protein 1(FGL1) novel mechanism that tumors may use to evade system by binding LAG-3 and negatively regulating T cells. In this study, we aimed at investigating underlying of FGL1 ccRCC, its expression prognostic value. We found was upregulated tumor tissues plasma specimens...
CD146 is highly expressed in various malignant tumors and associated with the poor prognosis. However, role of clear cell renal carcinoma (ccRCC) still unknown. This study aimed to identify ccRCC by integrated bioinformatics analysis.CD146 mRNA expression methylation data was examined using TIMER, UALCAN, MethSurv databases. paraffin-embedded tissues (140 cancer samples 140 paracancer tissues) from our cohort were immunohistochemistry assay. The LinkedOmics database used signaling pathways...
Spi-1 proto-oncogene (SPI1), which encodes an ETS-domain transcription factor, can activate gene expression in myeloid and lymphoid lineages. The role of SPI1 the tumor immune microenvironment clear cell renal carcinoma (ccRCC) remains unknown. In this study, we investigated possible ccRCC using independent cohort a comprehensive bioinformatics analysis.Quantitative real-time PCR, western blot immunohistochemistry assays were used to compare levels between tissues normal tissues, analyze...
Germline pathogenic variants are estimated to affect 3-5% of patients with renal cell carcinoma (RCC). The identification hereditary RCC is important for cancer screening and treatment guidance.Whole-exome sequencing (WES) (n=69) or gene panel containing 139 genes (n=54) related germline predisposition was used analyze mutations in 123 admitted Department Urology, Third Medical Center Chinese PLA General Hospital. Chi-square test (χ2) relationship between clinicopathologic parameters...
Accurate granularity estimation of ore images is vital in automatic geometric parameter detecting and composition analysis dressing progress. Machine learning based methods have been widely used multi-scenario estimation. However, the adhesion coal particles usually results lower segmentation accuracy. Because much powdery fills between blocky ones, making edge contrast them not distinct. Currently, still carried out empirical nature. We propose a novel method for on deep neural network...
Purpose To investigate the significance of demographic and pathological characteristics on survival outcomes urachal adenocarcinoma (UrAC), primary bladder (BAC) urothelial carcinoma with glandular differentiation (UCGD) in China. Materials Methods We retrospectively analyzed cases non-distant metastases (≤ T4M0). Of 106 patients, 30 (28.3%), 40 (37.7%), 36 (34.0%) met criteria for UrAC, BAC, UCGD, respectively. Data patient demographics, tumor pathology, were collected. The median follow-up...
Birt-Hogg-Dube syndrome is an autosomal dominant condition that arises from germline folliculin (FLCN) mutations. It characterized by skin fibrofolliculomas, lung cysts, pneumothorax, and renal cancer. Here, we present the case of a 36-year-old woman with asymptomatic, multiple tumors history spontaneous pneumothorax. Genetic analysis revealed hotspot FLCN mutation, c.1285dupC (p.H429fs), novel somatic c.470delT (p.F157fs). This information results immunohistochemical indicated features...
In this paper, a 3-D numerical model is proposed to investigate the capability of generating high operating temperature for modified solar cavity receiver in large-scale dish Stirling system. The aims evaluate influence radiation intensity on performance. properties heat transfer fluid pipe and losses are investigated by varying direct normal irradiance from 400W/m2 1000W/m2. fluid, as well effect have been critically presented discussed. simulation results reveal that thermal efficiency...
Abstract Objectives : To evaluate the prognostic value of preoperative lymphocyte to monocyte ratio (LMR) in patients with renal cell carcinoma and venous tumor thrombus (RCC-VTT) after surgery. Methods We retrospectively reviewed medical data 144 consecutive RCC level I-IV VTT Kaplan-Meier method was used assess compare survival. Univariable multivariable Cox proportional hazard models were constructed identify independent factor for The Harrell concordance index predictive accuracy....
Abstract Background : The aim of the study was to evaluate prognostic value preoperative lymphocyte monocyte ratio (LMR) in patients with renal cell carcinoma and inferior vena cava tumor thrombus (RCC-IVCTT) after surgery. Methods We retrospectively reviewed medical data 144 consecutive who underwent RCC-IVCTT Time-dependent receiver operating characteristic curve analysis performed calculate optimal cutoff for LMR. Kaplan-Meier method used assess compare survival. Univariable multivariable...
Abstract Background: Cell division cycle-associated 5 (CDCA5) protein, which is involved in cohesion, contributes to cell cycle regulation and chromosome segregation by maintaining genomic stability. Accumulating evidence indicates that CDCA5 upregulated many types of cancers with poor prognoses. However, it remains largely unknown about the biological function clear renal carcinoma (ccRCC). Methods: UALCAN databases were used display expression profile its prognosis ccRCC patients....