A5100678220- Cancer-related molecular mechanisms research
- Drug Transport and Resistance Mechanisms
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Prostate Cancer Treatment and Research
- Urinary Bladder and Prostate Research
- Circular RNAs in diseases
- Prostate Cancer Diagnosis and Treatment
- MicroRNA in disease regulation
- RNA Research and Splicing
- Hormonal and reproductive studies
- Pediatric Hepatobiliary Diseases and Treatments
- Sexual function and dysfunction studies
- Virus-based gene therapy research
- Ferroptosis and cancer prognosis
- Smart Grid Energy Management
- Lipid metabolism and disorders
- Inflammatory mediators and NSAID effects
- Pharmacological Effects and Toxicity Studies
- Bone health and treatments
- Osteoarthritis Treatment and Mechanisms
- Nanoplatforms for cancer theranostics
- Viral Infectious Diseases and Gene Expression in Insects
- RNA and protein synthesis mechanisms
- Autophagy in Disease and Therapy
Sichuan University
2018-2025
West China Hospital of Sichuan University
2018-2025
Wenzhou Medical University
2024-2025
Union Hospital
2024
Harbin Medical University
2024
Fujian Medical University
2024
Northwest University
2024
Wenzhou University
2023-2024
Beijing Center for Disease Prevention and Control
2023
Shanghai University of Electric Power
2023
Metabolic reprogramming fuels cancer cell metastasis and remodels the immunosuppressive tumor microenvironment (TME). We report here that circPETH, a circular RNA (circRNA) transported via extracellular vesicles (EVs) from tumor-associated macrophages (TAMs) to hepatocellular carcinoma (HCC) cells, facilitates glycolysis in recipient HCC cells. Mechanistically, circPETH-147aa, encoded by circPETH an m6A-driven manner, promotes PKM2-catalyzed ALDOA-S36 phosphorylation MEG pocket. Furthermore,...
Abstract Understanding the roles of noncoding RNAs (ncRNA) in tumorigenesis and metastasis would establish novel avenues to identify diagnostic therapeutic targets. Here, we aimed hepatocellular carcinoma (HCC)–specific ncRNA investigate their hepatocarcinogenesis metastasis. RNA-seq xenografts generated by lung identified long RNA small nucleolar host gene 10 (SNHG10) its homolog SCARNA13 as drivers for development HCC. SNHG10 expression positively correlated with 64 HCC cases, high or was...
Depression is a neuropsychiatric disease associated with neuronal anomalies within specific brain regions. In the present study, we screened microRNA (miRNA) expression profiles in dentate gyrus (DG) of hippocampus and found that miR-26a-3p was markedly downregulated rat model depression, whereas upregulation DG regions rescued deterioration depression-like phenotypes resulting from stress exposure, effects appear to be mediated by PTEN pathway. The knockdown normal control rats induced...
Abstract Background The HSP70 family of heat shock protein plays a critical role in synthesis and transport to maintain homeostasis. Several studies have indicated that HSP70s are related the development occurrence various cancers. Methods relationship between overall survival rate hepatocellular carcinoma patients expression 14 from multiple databases, such as TCGA, ONCOMINE, cBioPortal was investigated. Western Blot PCR were used evaluate HSPA4 HSPA14 expressions HCC cells identify...
Abstract Background Hepatocellular carcinoma (HCC) is the world’s third leading cause of cancer-related death; due to fast growth and high prevalence tumor recurrence, prognosis HCC patients remains dismal. Long non-coding RNA CEBPA-DT, a divergent transcript CCAAT Enhancer Binding Protein Alpha (CEBPA) gene, has been shown participate in multiple progression. However, no research established its cancer-promoting mechanism yet. Methods CEBPA-DT was identified human tissues through...
Highlights•PTEN/TP53 loss drives HK2-dependent prostate tumor growth bypassing anti-AR axis therapy•Targeting HK2-mediated Warburg effect activates AMPK-ULK1-dependent autophagy for cell survival•Targeting regulates AMPK-mTORC1-S6K1 translation signaling to reduce MCL-1 apoptosis•Co-targeting and suppresses in Pten-/p53-deficient cancer modelsAbstractCurrently, no therapeutic options exist castration-resistant (CRPC) patients who have developed resistance the second generation anti-androgen...
Photoacoustic imaging (PAI) is a new and attractive modality, it has strong potential for application in the early detection of tumors through use optically absorbing targeted contrast agents. Ag2S quantum dots (QD) are promising bionanomaterial have attracted significant attention field bioimaging. In this study, water-soluble carboxylic acid group-coated QDs with an ultrasmall size (∼8 nm) were synthesized via one-step method. Their surface plasmon resonance wavelength was determined to be...
The macrolide antibiotics azithromycin and clarithromycin are large molecular weight compounds that exhibit moderate to excellent oral bioavailability in preclinical species humans. Previous concomitant dosing studies rats using rifamycin SV, a general organic anion-transporting polypeptide (OATP) inhibitor, suggested the high absorption of may be caused by facilitative uptake intestinal Oatps. In this study, we used OATP/Oatp-expressing cells investigate interaction macrolides with rat...
Abstract Hepatocellular carcinoma (HCC) is one of the most prevalent subtypes liver cancer worldwide. LncRNAs have been demonstrated to be associated with progression HCC, but a systematic identification and characterization their clinical roles molecular mechanisms in HCC has not conducted. In this study, aberrantly expressed lncRNAs tissues were analyzed based on TCGA RNA-seq data. 1162 found tissues, including 232 down-regulated 930 up-regulated lncRNAs. The top 5 highest diagnostic...
Hepatocellular carcinoma (HCC) remains one of the most lethal malignant tumors. Multimodal therapeutics with synergistic effects for treating HCC have attracted increasing attention, instance, designing biocompatible porphyrin-based nanomedicines enzyme-mimetic and ultrasound (US)-activable reactive oxygen species (ROS) generation. Despite promise, landscape such advancements sparse. Here, we propose de novo design a π-conjugated, osmium (Os)-coordinated polyporphyrin (P-Por-Os) nanovesicle...
Background Long non-coding RNA (LncRNA) plays an important role in the occurrence and development of hepatocellular carcinoma (HCC). This study aims to establish immune-related LncRNA model for risk assessment prognosis prediction HCC patients. Methods Hepatocellular patient samples with complete clinical data corresponding whole transcriptome expression were obtained from Cancer Genome Atlas (TCGA). Immune-related genes acquired Gene Set Enrichment Analysis (GSEA) website matched TCGA get...
The current study aimed to identify a comprehensive expression-profile of microRNAs (miRNAs) in expressed prostatic secretion (EPS) collected from healthy men and patients with CP/CPPS (Chronic prostatitis/Chronic pelvic pain syndrome). After clinical screening 382 participants, 60 59 IIIA significant pelvic-pain were included into this March 2012 December 2014. High-throughput sequencing was employed characteristic EPS-miRNAs. QRT-PCR further performed confirm elevated levels differential...
Objective The workers in emerging manufacturing are at decreased risk of traditional occupational diseases, while probably increased work-related musculoskeletal disorders (WMSDs). This study aimed to investigate the prevalence and factors WMSDs among Beijing. Methods A total 3,359 valid questionnaires were collected from 10 enterprises electronics, pharmaceutical, motor industries. was assessed using Nordic Musculoskeletal Questionnaire. work posture load evaluated through a questionnaire....
<i>Background/Aims:</i> Mutations in the apical sodium-dependent bile acid transporter <i>(SLC10A2)</i> block intestinal absorption, resulting a compensatory increase hepatic synthesis. Inactivation of basolateral membrane (OSTα-OSTβ) also impairs but synthesis was paradoxically repressed. We hypothesized that altered homeostasis resulted from ileal trapping acids act via farnesoid X receptor (FXR) to induce overexpression FGF15. To test this hypothesis, we...
Current studies support lipid ratios [the total cholesterol (TC)/high-density lipoprotein (HDL-C) ratio; the triglyceride (TG)/HDL-C low-density (LDL -C)/HDL-C and non-HDL-C] as reliable indicators of cardiovascular disease, stroke, diabetes. However, whether could serve markers for hyperuricemia (HUA) remains unclear due to limited research. This study aimed explore association between HUA in hypertensive patients.The data from 14,227 Chinese individuals were analyzed. Multiple logistic...