A5039248175- Ferroptosis and cancer prognosis
- Thyroid Cancer Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Machine Learning in Bioinformatics
- Biomarkers in Disease Mechanisms
- Cancer-related molecular mechanisms research
- Microbial Fuel Cells and Bioremediation
- Bioinformatics and Genomic Networks
- Liver Disease Diagnosis and Treatment
- Photodynamic Therapy Research Studies
- Head and Neck Anomalies
- Prostate Cancer Treatment and Research
- Nanoplatforms for cancer theranostics
- Thyroid and Parathyroid Surgery
- Microbial Community Ecology and Physiology
- Complement system in diseases
- Liver Diseases and Immunity
- Cancer Immunotherapy and Biomarkers
- Gene Regulatory Network Analysis
- Inflammatory Bowel Disease
- Higher Education and Teaching Methods
- CO2 Reduction Techniques and Catalysts
- Cancer, Hypoxia, and Metabolism
- Electrocatalysts for Energy Conversion
Sichuan University
2024
West China Hospital of Sichuan University
2024
Hangzhou Normal University
2024
China Medical University
2021-2023
First Hospital of China Medical University
2021-2023
Jinhua Central Hospital
2023
Zhejiang University
2023
Chizhou University
2007-2022
Papillary thyroid carcinoma (PTC) is the most common type of cancer (TC), accounting for more than 80% all cases. Ferroptosis a novel iron-dependent and Reactive oxygen species (ROS) reliant cell death which distinct from apoptosis, necroptosis pyroptosis. Considerable studies have demonstrated that ferroptosis involved in biological process various cancers. However, role PTC remains unclear. This study aims at exploring expression ferroptosis-related genes (FRG) their prognostic values PTC.
Pyroptosis is a form of programmed cell death triggered by inflammasomes. However, the roles pyroptosis-related genes in thyroid cancer (THCA) remain still unclear.This study aimed to construct signature that could effectively predict THCA prognosis and survival.A LASSO Cox regression analysis was performed build prognostic model based on expression profile each gene. The predictive value validated internal cohort.A consisting four constructed all patients were classified into high- low-risk...
Hepatocellular carcinoma (HCC) remains one of the most lethal malignant tumors. Multimodal therapeutics with synergistic effects for treating HCC have attracted increasing attention, instance, designing biocompatible porphyrin-based nanomedicines enzyme-mimetic and ultrasound (US)-activable reactive oxygen species (ROS) generation. Despite promise, landscape such advancements sparse. Here, we propose de novo design a π-conjugated, osmium (Os)-coordinated polyporphyrin (P-Por-Os) nanovesicle...
Stromal and immune cells are major components of tumor microenvironment (TME) affect the growth development thyroid carcinoma (THCA). However, data on exact mechanisms that define relationship between TME THCA remain scant. We calculated stromal scores proportion tumor-infiltrating (TICs) by CIBERSORT ESTIMATE based gene expression from Cancer Genome Atlas (TCGA). In addition, we evaluated differentially expressed genes (DEGs) high- low-score groups performed functional enrichment analysis....
Cuproptosis is a novel programmed cell death that depends on copper. The role and potential mechanism of cuproptosis-related genes (CRGs) in thyroid cancer (THCA) are still unclear. In our study, we randomly divided THCA patients from the TCGA database into training set testing set. A signature consisting six (SLC31A1, LIAS, DLD, MTF1, CDKN2A, GCSH) was constructed using to predict prognosis verified with All were classified low- high-risk groups according risk score. Patients group had...
Background: Necroptosis, a type of programmed cell death, has been implicated in variety cancer-related biological processes. However, the roles necroptosis-related genes thyroid cancer yet remain unknown. Methods: A gene signature was constructed using least absolute shrinkage and selection operator (LASSO) regression analysis Cox analysis. The predictive value prognostic validated an internal cohort. Additionally, single-sample set enrichment (ssGSEA) used to examine relationships between...
The functional alterations of eRNAs have been reported to be correlated with tumorigenesis. However, the roles in thyroid cancer (THCA) remain still unclear. This study aimed construct an immune-related eRNA prognostic signature that could effectively predict survival and prognosis for THCA.The Weighted Gene Co-Expression Network Analysis (WGCNA) was performed identify THCA-specific hub genes were obtained using Pearson correlation analysis. Univariate least absolute shrinkage selection...
Observational studies have indicated that immune dysregulation in primary sclerosing cholangitis (PSC) primarily involves intestinal-derived cells. However, the causal relationship between peripheral blood cells and PSC remains insufficiently understood.
Abstract Purpose c -Type cytochromes are essential for extracellular electron transfer (EET) in electroactive microorganisms. The expression of appropriate -type is an important feature these microorganisms response to different acceptors. However, how diverse tightly regulated still poorly understood. Methods In this study, we identified the high co-fitness genes that potentially work with by using genome-wide analysis. We also constructed and studied networks composed top 20 them. Results...
Because of the ability to metabolize a large number electron acceptors such as nitrate, nitrite, fumarate, and metal oxides, Shewanella species have attracted much attention in recent years. Generally, use these is mainly achieved through transfer proteins their interactions which will dynamically change across different environmental conditions cells. Therefore, functional analysis condition-specific molecular networks can reveal biological information on processes. By integrating...
Abstract Background Hepatocellular carcinoma (HCC) is extremely heterogeneous, abd predicting patient outcomes remains a challenge. Anoikis distinct type of cell death that exerts an essential role in oncogenic invasion and spread. The presence anti-anoikis factors contributes to cancer aggressiveness drug resistance. Methods HCC transcriptomic clinical data were accessed using public databases. A least absolute shrinkage selection operator (LASSO) Cox approach was used define multigenic...
Abstract Background The functional alterations of eRNAs have been reported to be correlated with tumorigenesis. However, the roles in thyroid cancer (THCA) remain still unclear. This study aimed construct an immune-related eRNA prognostic signature that could effectively predict survival and prognosis for THCA. Methods Weighted Gene Co-Expression Network Analysis (WGCNA) was performed identify THCA-specific hub genes were obtained using Pearson correlation analysis. Univariate least absolute...
Abstract Background: Stromal and immune cells are major components of tumor microenvironment (TME) affect the growth development thyroid carcinoma (THCA). However, data on exact mechanisms that define relationship between TME THCA remains scant. Results: Here, we calculated stromal scores proportion tumor-infiltrating (TICs) by CIBERSORT ESTIMATE based gene expression from The Cancer Genome Atlas database (TCGA). In addition, evaluated differentially expressed genes (DEGs) high- low-score...
Abstract Background : Papillary thyroid carcinoma (PTC) is the most common type of cancer (TC), accounting for more than 80% all cases. Ferroptosis a novel iron-dependent and Reactive oxygen species (ROS) reliant cell death which distinct from apoptosis, necroptosis pyroptosis. Considerable studies have demonstrated that ferroptosis involved in biological process various cancers. However, role PTC remains unclear. This study aims at exploring expression ferroptosis-related genes (FRG) their...