A5100721745- MicroRNA in disease regulation
- Obstructive Sleep Apnea Research
- Liver Disease Diagnosis and Treatment
- Neuroscience of respiration and sleep
- RNA modifications and cancer
- Sleep and Wakefulness Research
- Cancer, Hypoxia, and Metabolism
- Traditional Chinese Medicine Studies
- Pancreatic function and diabetes
- Temporomandibular Joint Disorders
- Phagocytosis and Immune Regulation
- Epigenetics and DNA Methylation
- Oral and Maxillofacial Pathology
- Voice and Speech Disorders
- Dysphagia Assessment and Management
- Cleft Lip and Palate Research
- dental development and anomalies
- Genetic Associations and Epidemiology
- Sleep and related disorders
- Bone and Dental Protein Studies
- Amino Acid Enzymes and Metabolism
- Mesenchymal stem cell research
- Orthodontics and Dentofacial Orthopedics
- Piperaceae Chemical and Biological Studies
- Birth, Development, and Health
Sichuan University
2014-2025
Stomatology Hospital
2018-2024
Peking University
2010-2024
Panyu District Central Hospital
2024
Guangzhou Medical University
2024
Nanjing Medical University
2022-2024
Jiangsu Province Hospital
2022-2024
Wuhan University
2020-2024
Renmin Hospital of Wuhan University
2020-2024
Technical University of Munich
2024
Abstract Pyroptosis, an inflammatory caspase-dependent programmed cell death, plays a vital role in maintaining tissue homeostasis and activating responses. Orthodontic tooth movement (OTM) is aseptic force-induced bone remodeling process mediated by the activation of periodontal ligament (PDL) progenitor cells. However, whether how force induces PDL pyroptosis, thereby influencing OTM alveolar remains unknown. In this study, we found that mechanical induced expression pyroptosis-related...
Abstract The regenerative treatment of infectious vertical bone defects remains difficult and challenging today. Current clinical treatments are limited in their ability to control bacteria infection, which is unfavorable for new formation calls a type material with excellent osteogenic antibacterial properties. Here multifunctional scaffold synthesized that mimics natural nanostructures by incorporating silver nanowires into hierarchical, intrafibrillar mineralized collagen matrix...
Abstract Scaffolding adapter Grb2-associated binder 2 (Gab2) is a key component of FcεRI signaling in mast cells, required for the activation PI3K. To understand how Gab2 activated signaling, we asked which protein tyrosine kinase phosphorylation. We found that tyrosyl phosphorylation requires Lyn and Syk. In agreement with published results, Fyn also contributes to However, Syk defective Fyn−/− suggesting proximal responsible Then, domains are Grb2-Src homology 3 (SH3) binding sites for,...
The scaffolding adapter Gab2 mediates cell signaling and responses evoked by various extracellular stimuli including several growth factors. Kit, the receptor for stem factor (SCF), plays a critical role in proliferation differentiation of variety types, mast cells. via Tyr(567) Tyr(719), activates Src family kinases (SFK) PI3K respectively, which converge on activation Rac/JNK pathway required proliferation. However, how Kit signals to is not well understood. By analyzing Gab2(-/-) cells,...
Periodontal ligament (PDL), as a mechanical connection between the alveolar bone and tooth, plays pivotal role in force-induced orthodontic tooth movement (OTM). However, how force controls remodeling of PDL collagenous extracellular matrix (ECM) is largely unknown. Here, we aimed to evaluate stress distribution ECM fiber during process OTM. An experimental model was built by ligating coil spring left maxillary first molar central incisors. After activating for 7 days, distance 0.324 ± 0.021...
Evidence of associations between type-specific bullying victimization and suicidal ideation suicide attempt among adolescents is scant. This study examined these middle high school students in China.A cross-sectional 27,030 with mean age 15.7 ± 1.7 years, including 13,946 boys 13,084 girls, was carried out April June 2022.The prevalence 19.7 % 2.9 %, respectively. 30.0 (95%CI: 28.8-31.1) reported being bullied (i.e., victimization) the past 30 days, corresponding figs. (95%CI) for verbal...
Mandibular advancement device (MAD) is a good alternative for patients with obstructive sleep apnea (OSA). However, the treatment response varies amongst individuals.This study aimed to explore role of craniofacial features in MADs improve prognostication and patient selection.The retrospective trial contained 42 males aged 41.5 ± 9.0 years, an apnea-hypopnea index (AHI) 21.5 13.8 events/h. According mandibular plane angle, participants were divided into three groups: low angle (n = 13),...
Abstract Hemorrhage is a common clinical manifestation in patients with cancer. Intratumor hemorrhage has been demonstrated to be poor prognostic factor for cancer patients. In this study, we investigated the role of RBCs and hemoglobin (Hb) process tumor progression therapeutical response. Hb potently promoted cell proliferation syngenic growth. activated reactive oxygen species–NF-κB pathway both cells macrophages. also induced chemoresistance mediated, part, by upregulating ABCB1 gene...
Oligosaccharides play crucial roles in many biorecognition processes by the so-called "cluster glycosidic effect". We here report a facile synthesis of lactose-CdSeS/ZnS quantum dot conjugate (Lac-QDs) use 1-thiol-β-d-lactose via ligand exchange, which exhibits significantly high affinity and specificity to leukocytes contrast monovalent lactose. Structural analyses indicate that there are about 132 lactosyl molecules assembled on single QDs hydrodynamic diameter is small, close 8.2 nm....
Tongue plays an important part in oral and maxillofacial system. Measurement of tongue pressure helps to evaluate the performance movement.To establish a system for measuring against hard palate preliminarily explore distribution individual normal occlusions relationship with dental arch form.A total 19 volunteers out 189 students met inclusion criteria (nine males, ten females, aged 25.53 ± 0.96 years). A force-sensing resistor device was used measure at rest functional state (swallowing)....
Transcription factor SOX2 is multiple phosphorylated. However, the kinase and timing regulating phosphorylation remains poorly understood. Here we reported mitotic of by Aurora A (AURKA). AURKA inhibitors (VX680, Inhibitor I) but not PLK1 (BI2536, CBB2001) eliminate SOX2. Consistently, siRNA inhibition can phosphorylation. Ser220 Ser251 are two sites that identified for on Moreover, mutants (S220A S251A) promote induced OCT4 re-expression in differentiated cells. These findings reveal a...
To analyze the effect of gradual increments mandibular advancement on treatment efficacy devices and identify determinants effective target protrusion for OSA.Patients were prospectively recruited. The mandible was titrated from 0 mm with a stepwise increment 0.5 until AHI reduced to lowest level. Rhinospirometry, rhinomanometry, magnetic resonance imaging used observe change respiratory function upper airway morphology.Forty-two patients aged 41.5 ± 9.0 years participated. There...
Objectives To explore the relationship between sleep duration and cognitive functions in older adults using NHANES, a national US population study dataset, to causal association with Mendelian randomization (MR) UK Biobank. Methods First, an observational was conducted NHANES database participants ≥60 years. Sleep measured accelerometers for 7 consecutive days. Participants were divided into habitual short (<7 h) long (>9 groups. Cognitive CERAD Word Learning sub-set, Animal Fluency,...
Zebrafish is a prominent vertebrate model for low cost in vivo whole organism screening. In our recent screening of the distribution patterns fluorescent compounds live zebrafish larvae, fifteen with tissue-specific distributions were identified. Several observed to accumulate tissues where they reported induce side effects, and similar structures tended be enriched same tissues, minor differences. particular, we found three novel red bone staining dyes: purpurin, lucidin...