A5103072883- Sepsis Diagnosis and Treatment
- Acute Kidney Injury Research
- Chronic Kidney Disease and Diabetes
- Astronomy and Astrophysical Research
- Astronomical Observations and Instrumentation
- Renal function and acid-base balance
- Stellar, planetary, and galactic studies
- Pneumonia and Respiratory Infections
- Hemodynamic Monitoring and Therapy
- Immune Response and Inflammation
- Respiratory viral infections research
- Neonatal Respiratory Health Research
- CAR-T cell therapy research
- Influenza Virus Research Studies
- Nosocomial Infections in ICU
- Cancer-related molecular mechanisms research
- Protein Degradation and Inhibitors
- Neonatal and Maternal Infections
- Intensive Care Unit Cognitive Disorders
- Respiratory Support and Mechanisms
- Autoimmune and Inflammatory Disorders Research
- RNA regulation and disease
- Cardiac Arrest and Resuscitation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immunotherapy and Immune Responses
Stomatology Hospital
2025
Sun Yat-sen University
2025
Soochow University
2015-2024
People's Hospital of Xinjiang Uygur Autonomous Region
2024
Soochow University
2019-2022
Children's Hospital of Suzhou University
2021
National Astronomical Observatories
2017
Temple University
2015
Acute kidney injury (AKI) is a common and serious organ dysfunction in critically ill children. Early identification prediction of AKI are great significance. However, current criteria insufficiently sensitive specific, heterogeneity limits the clinical value biomarkers. This study aimed to establish validate an explainable model based on machine learning (ML) approach for AKI, assess its prognostic implications children admitted pediatric intensive care unit (PICU).
Abstract Background Hyperlactatemia upon admission is a documented risk factor for mortality in critically ill adult patients. However, the predictive significance of single lactate measurement at general population children remains uncertain. This study evaluated value blood levels and determined cut-off values predicting in-hospital pediatric population. Methods We enrolled 1109 who were admitted to intensive care unit between July 2008 December 2010. Arterial samples collected first 2...
To evaluate whether early and acquired daily fluid overload (FO), as well fluctuations in accumulation, were associated with adverse outcomes critically ill children severe sepsis.This study enrolled 202 a pediatric intensive care unit (PICU) sepsis. Early was defined ≥5% accumulation occurring the first 24 hours of PICU admission. The maximum during next 6 days patients at least 48 stay PICU-acquired overload. fluctuation calculated difference between minimum obtained 7 after admission.Of...
Abstract Background T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive disease with a high risk of induction failure and poor outcomes, relapse due to drug resistance. Recent studies show that bromodomains extra-terminal (BET) protein inhibitors are promising anti-cancer agents. ARV-825, comprising BET inhibitor conjugated cereblon ligand, was recently developed attenuate the growth multiple tumors in vitro vivo. However, functional molecular mechanisms ARV-825 T-ALL remain...
Abstract Background Nosocomial infections (NIs) are an important cause of mortality, and increasing evidence reveals that the prevalence NIs can be reduced through effective prevention control measures. The aim this study was to investigate impact measures for COVID-19 pandemic on NIs. Methods A retrospective conducted analyze before after 6 months in Children’s Hospital Soochow University. Results total 39,914 patients 2019 34,645 2020 were admitted hospital during study. There 1.39%...
Abstract Background Pneumonia is the major cause of death under 5 years. With high CAP numbers in China and growing access to PICUs, factors associated with severe need be determined optimize care. Objective To prospectively determine PICU admission features outcomes. Methods A 4 year prospective study aged 1 month <14 years admitted PICU, Children's Hospital Affiliated Soochow University, China. All were managed a standard manner. Clinical, laboratory, imaging findings collected...
Abstract Notch signaling regulates multiple helper CD4+ T cell programs. We have recently demonstrated that dendritic cells (DCs) expressing the ligand DLL4 are critical for eliciting alloreactive responses and induction of graft-versus-host disease in mice. However, human counterpart murine DLL4+ DCs has yet to be examined. report identification their role regulating Th1 Th17 differentiation. CD1c+ plasmacytoid (pDCs) from peripheral blood (PB) healthy donors did not express DLL4. In...
The detection of microbial pathogens relies on the recognition highly conserved structures by membrane sensor Toll-like receptors (TLRs) and cytosolic NOD-like (NLRs). Upon detection, these sensors trigger innate immune responses to eradicate invaded pathogens. However, it is unclear whether TLR NOD signaling are both critical for immunity initiate inflammatory antimicrobial against infection. Here we report that activation resulted in an augmented response crosstalk between led amplified...
To investigate the clinical sub-phenotype (SP) of pediatric acute kidney injury (AKI) and their association with outcomes. General status initial values laboratory markers within 24 hours after admission to intensive care unit (PICU) were recorded for children AKI in derivation cohort (n=650) validation (n=177). In cohort, a least absolute shrinkage selection operator (LASSO) regression analysis was used identify death-related indicators, two-step cluster employed obtain SP AKI. A logistic...
Circadian rhythm disruption, commonly caused by factors such as jet lag and shift work, is increasingly recognized a critical factor impairing wound healing. Although melatonin known to regulate circadian rhythms has potential in repair, its clinical application limited low bioavailability. To address these challenges, we developed an alginate-based dual-network hydrogel delivery system for melatonin, ensuring stable sustained release at the site. This approach enhances efficacy of...
<title>Abstract</title> Insider threats can cause significant damage to a business or organisation, and insider threat detection is critical maintaining the security of vital corporate information. By evaluating monitoring behaviours visiting users, abnormal behaviours, unusual activities potential threatening be detected at an early stage, which will help improve identification in business/organisation take effective measures deal with risks. Existing methods rely more on predefined rules,...
Research on acute kidney injury (AKI) has focused identifying early biomarkers. However, whether AKI could be diagnosed in the absence of classic signs clinical and condition subclinical AKI, identified by damage or functional biomarkers oliguria increased serum creatinine (sCr) levels, is clinically significant remains to elucidated critically ill children. The aims study were investigate associations between urinary cystatin C (uCysC) levels mortality determine uCysC-positive associated...
Abstract The radial velocity (RV) is a basic physical quantity that can be determined through the Doppler shift of spectrum star. precision RV measurement depends on resolution we used and accuracy wavelength calibration. In this work, velocities Large Sky Area Multi-Object Fibre Spectroscopic Telescope-II (LAMOST-II) medium-resolution ( R ∼ 7500) spectra are measured for 1,594,956 (each has two wavebands) matching with templates. A set standard stars to recalibrate zero point measurement,...
Acute lung injury (ALI) caused by sepsis is a common respiratory critical illness with high morbidity and mortality. Protein kinase C-alpha (PRKCA) plays protective role in sepsis-induced ALI.
Abstract High mobility group box 1 (HMGB1), a chromatin-binding nuclear protein, plays critical role in sepsis by acting as key “late-phase” inflammatory mediator. Integrin CD11b is essential for cell activation and migration, thus mediating responses. However, it unclear whether participates the development of sepsis. In this study, we report that contributes to LPS-induced endotoxin shock microbial sepsis, antagonism with blocking Ab or inhibitor Gu-4 protects mice against LPS-...
Substantial interstudy heterogeneity exists in defining acute kidney injury (AKI) and baseline serum creatinine (SCr). This study assessed AKI incidence its association with pediatric intensive care unit (PICU) mortality under different SCr definitions to determine the preferable approach for diagnosing AKI.In this multicenter prospective observational cohort study, was defined staged according Kidney Disease: Improving Global Outcome (KDIGO), modified KDIGO, reference change value optimized...
POLR3-related leukodystrophy is an autosomal recessive neurodegenerative disorder characterized by onset time ranging from the neonatal period to late childhood, progressive motor decline that manifests as spasticity, ataxia, tremor, and cerebellar symptoms, well mild cognitive regression hypodontia. belongs family of RNA polymerase III-related leukodystrophy, which are caused biallelic mutations in POLR3A, POLR3B, POLRC1, or POLR3K genes. In this study, we report a female child with...
Neonates are susceptible to a wide range of microbial infection and at high risk develop severe sepsis septic shock. Emerged evidence has shown that induction trained immunity triggers much stronger inflammatory response in adult monocytes/macrophages, thereby conferring protection against infection.This study was carried out examine whether is inducible exerts its neonates.Induction by Bacillus Calmette-Guerin (BCG) plus bacterial lipoprotein (BLP) protected neonatal mice cecal slurry...
Abstract Background There are incomplete data on the global burden of viral lower respiratory tract infection, in particular role Respiratory Syncytial Virus, children requiring health services. Findings In this study set a large urban area southern China from 1 January 2007 to 31 December 2010, month 14 years age with RSV-associated “severe” or “very severe pneumonia” according World Health Organization definitions, and meeting local criteria for admission pediatric intensive care unit,...
The aims of this study are to evaluate the relationship between early blood glucose concentrations and mortality define a 'safe range' during first 24 h after pediatric intensive care unit (PICU) admission with lowest risk mortality. We further determine whether associations exist PICU hyperglycemia hypoglycemia occurring within admission, even adjusting for illness severity assessed by III (PRISM III) score.This retrospective cohort included patients admitted July 2008 June 2011 in tertiary...