A5046577446- Bone Tissue Engineering Materials
- Nerve injury and regeneration
- Bone Metabolism and Diseases
- Spinal Cord Injury Research
- Orthopaedic implants and arthroplasty
- Magnesium Alloys: Properties and Applications
- Tissue Engineering and Regenerative Medicine
- Neurogenesis and neuroplasticity mechanisms
- RNA Interference and Gene Delivery
- Acupuncture Treatment Research Studies
- Graphene and Nanomaterials Applications
- Sperm and Testicular Function
- Cerebral Palsy and Movement Disorders
- Dental Implant Techniques and Outcomes
- Endodontics and Root Canal Treatments
- Mesenchymal stem cell research
- Bone health and treatments
- Neuroscience and Neural Engineering
- Magnesium in Health and Disease
Xi'an Honghui Hospital
2022-2024
Xi'an Jiaotong University
2022-2024
Neural stem cells (NSCs) are considered to be prospective replacements for neuronal cell loss as a result of spinal cord injury (SCI). However, the survival and differentiation NSCs strongly affected by unfavorable microenvironment induced SCI, which critically impairs their therapeutic ability treat SCI. Herein, strategy fabricate PDGF-MP hydrogel (PDGF-MPH) microspheres (PDGF-MPHM) instead bulk hydrogels is proposed dramatically enhance efficiency platelet-derived growth factor mimetic...
Abstract Active artificial bone substitutes are crucial in repair and reconstruction. Calcium phosphate cement (CPC) is known for its biocompatibility, degradability, ability to fill various shaped defects. However, low osteoinductive capacity limits regeneration applications. Effectively integrating magnesium ions with CPC remains a challenge. Herein, we developed malate-modified (MCPC). Incorporating 5% malate significantly enhances the compressive strength of (6.18 ± 0.49) MPa, reduces...
Calcium phosphate cement (CPC) has been widely studied, but its lack of osteoinductivity and inadequate mechanical properties limit application, while strontium is able to promote bone formation inhibit resorption. In this study, different proportions tristrontium silicate were introduced create a novel strontium-modified calcium (SMPC). The physicochemical SMPC CPC compared, the microstructures cements characterized with scanning electron microscopy assays. Then, effect on cell...
Neural tissue engineering is an essential strategy to repair long-segment peripheral nerve defects. Modification of the conduit effective way improve local microenvironment injury site and facilitate regeneration. However, concurrent release multiple growth cues that regulate activity Schwann cells neurons remains a challenge. The present study involved fabrication composite hydrogel, specifically methacrylate-anhydride gelatin-ciliary neurotrophic factor/insulin-like factor-1...
Modified macroporous structures and active osteogenic substances are necessary to overcome the limited bone regeneration capacity low degradability of self-curing calcium phosphate cement (CPC). Curcumin (CUR), which possesses strong activity poor aqueous solubility/bioavailability, esterifies side chains in hyaluronic acid (HA) form a water-soluble CUR-HA macromolecule. In this study, we incorporated glucose microparticles (GMPs) into CPC powder fabricate CUR-HA/GMP/CPC composite, not only...
Background: Spinal cord injury (SCI) induces neuronal death and disrupts the nerve fiber bundles, which leads to partial or complete sensorimotor function loss of limbs.Transplantation exogenous neurons derived from stem cells lesion site becomes a new neurorestorative strategy for SCI treatment.Spermatogonial (SSCs) can attain pluripotency features by converting embryonic stem-like in vitro.However, differentiating SSCs into lineage-specific is quite difficult low efficiency.Methods:...
Bone tissue engineering considers bone scaffolds as a key method for repairing critical-sized defects. Bone's unique combination of organic and inorganic elements, porous structure, mechanical strength is crucial. However, many artificial overlook the potential disruption to natural repair process, hindering clinical translation. We propose biomimetic perspective design that closely replicate bone's composition, strength, physiological process repair. The across four dimensions significantly...
Calcium phosphate cement (CPC) is an injectable bone with excellent biocompatibility, widely used for filling defects of various shapes. However, its slow degradation, insufficient mechanical strength, and poor osteoinductivity limit further clinical applications. In this study, we developed a novel composite magnesium-based calcium by integrating magnesium microspheres into PLGA fibers obtained through wet spinning incorporating these CPC. The inclusion enhanced the compressive strength...