A5101594274- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Wound Healing and Treatments
- Spinal Cord Injury Research
- Extracellular vesicles in disease
- Neuroendocrine regulation and behavior
- Spine and Intervertebral Disc Pathology
- RNA Interference and Gene Delivery
- Neuropeptides and Animal Physiology
- Stress Responses and Cortisol
- Musculoskeletal pain and rehabilitation
- Electrospun Nanofibers in Biomedical Applications
Air Force Medical University
2017-2020
Xijing Hospital
2017-2020
Institute of Oceanology
2011
Chinese Academy of Sciences
2011
Peripheral nerves are unique in their remarkable elasticity. Schwann cells (SCs), important components of the peripheral nervous system (PNS), constantly subjected to physiological and mechanical stresses from dynamic stretching compression forces during movement. So far, it is not clear if SCs sense respond signals. It also unknown whether stimuli can interfere with intercellular communications between neurons SCs, what role extracellular vesicles (EVs) play this process. The present study...
Delivery of multiple neurotrophic factors (NTFs), especially with time-restricted release kinetics, holds great potential for nerve repair. In this study, we utilized the tetracycline-regulatable Tet-On 3G system to control expression c-Jun, which is a common regulator NTFs in Schwann cells (SCs). vitro, Tet-On/c-Jun-modified SCs showed tightly controllable secretion NTFs, including glial cell line-derived NTF, growth factor, brain-derived and artemin, by addition or removal doxycycline...
Background Dopa decarboxylase (DDC) is a pyridoxal 5-phosphate (PLP)-dependent enzyme that catalyzes the decarboxylation of L-Dopa to dopamine, and involved in complex neuroendocrine-immune regulatory network. The function for DDC immunomodulation remains unclear invertebrate. Methodology full-length cDNA encoding (designated CfDDC) was cloned from mollusc scallop Chlamys farreri. It contained an open reading frame polypeptide 560 amino acids. CfDDC mRNA transcripts could be detected all...
Purpose: The clinical outcome of spinal cord injury is usually poor due to the lack axonal regeneration and glia scar formation. As one most classical supporting cells in neural regeneration, Schwann (SCs) provide bioactive substrates for migration release molecules that regulate growth. However, effect SC transplantation limited by their capacity astrocyte-rich central nervous system. Methods: In this study, we first magnetofected SCs with chondroitinase ABC-polyethylenimine functionalized...
Objective To explore the effect of single level lumbar disc herniation on morphology and diameter sciatic nerve, to identify correlation between change in nerve severity clinical symptoms, as well prognosis surgical treatment patients with herniation. Methods From January 1, 2017 December 31, 2017, Seventy (LDH) who underwent single-level posterior spine surgery were recruited this retrospective analysis study. Specific data including age, gender, a herniation, type symptomatic side,...