A5049106656- Autophagy in Disease and Therapy
- Aldose Reductase and Taurine
- Heme Oxygenase-1 and Carbon Monoxide
- Sperm and Testicular Function
- Anesthesia and Neurotoxicity Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Reproductive Biology and Fertility
- Spinal Cord Injury Research
- Calcium signaling and nucleotide metabolism
- Advanced Malware Detection Techniques
- Chalcogenide Semiconductor Thin Films
- Eicosanoids and Hypertension Pharmacology
- Silicon and Solar Cell Technologies
- Luminescence and Fluorescent Materials
- Dermatological and Skeletal Disorders
- Neonatal and fetal brain pathology
- Hydrogen's biological and therapeutic effects
- Acupuncture Treatment Research Studies
- solar cell performance optimization
- Cardiomyopathy and Myosin Studies
- Skin and Cellular Biology Research
- CNS Lymphoma Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- Food Quality and Safety Studies
- Hedgehog Signaling Pathway Studies
Hubei University of Science and Technology
2018-2021
Cangzhou Central Hospital
2021
Jinyintan Hospital
2021
Kunming Medical University
2017
Sichuan University
2017
Pingjin Hospital
2017
Guizhou Provincial People's Hospital
2016-2017
Kunming Children's Hospital
2017
The First Affiliated Hospital, Sun Yat-sen University
2016
Sun Yat-sen University
2016
Oxidative damage, inflammation, and apoptosis are the primary features of diabetic testicular damage. Curcumin protects against injury, but underlying mechanisms remain obscure. This study examined effect curcumin on type 2 diabetes mellitus- (T2DM-) induced oxidative stress, apoptotic changes. T2DM rats were intraperitoneally injected with 40 mg/kg STZ after being fed a high-fat diet for 8 weeks. One week injection, 100 or 200 was administered orally to 16 Histological changes in testes...
Approximately 90% of male diabetes mellitus patients have varying degrees testicular dysfunction. The molecular mechanism underlying diabetes-induced damage has not been thoroughly elucidated. In this research, we sought to determine the influence metformin (Met) on injury and involved with a focus dysfunction, apoptosis, autophagy, prokineticin 2 (PK2) signalling. our study, C57BL/6J mice were randomly divided into normal control group, Met-treated group. Streptozotocin (50 mg·kg-1·d-1) was...
Diabetic cardiomyopathy (DCM) is a complication of diabetes that can cause damage to myocardial structure and function. Metformin (Met) widely used type 2 treatment drug exerts cardioprotective effects through multiple pathways. Prokineticin (PK2) small-molecule secreted protein plays pivotal parts in cardiomyocyte survival angiogenesis. However, the role Met regulating PK2 signaling pathway DCM remains unclear. This experiment explored on high glucose (HG)-induced injury PK2/PKR vivo vitro....
Osteosarcoma is a kind of high-risk sarcoma the skeleton typically observed in people under 25 years old. Currently, radiotherapy widely applied cancer treatment. However, osteosarcoma radioresistant and accordingly new, more effective radiosensitizers are needed. miRNAs have been reported to play an important role radiosensitivity. We examined modulating effect miR‑328‑3p vivo vitro. was downregulated HOS‑2R cells. The overexpression enhanced radiosensitivity inhibited proliferation...
Traumatic brain injury (TBI) has been a serious public health issue. Clinically, there is an urgent need for agents to ameliorate the neuroinflammation and oxidative stress induced by TBI. Our previous research demonstrated that quercetin could protect neurological function. However, detailed mechanism underlying this process remains poorly understood.This was designed investigate mechanisms of cortical neurons.A modified weight-drop device used TBI model. 5, 20 or 50 mg/kg injected...
Aim: To investigate the protective effect of hypothermia (HT) on brain injury in moderate traumatic (TBI) rat models and potential mechanisms, especially involvement RIPK1 apoptosis necroptosis.Methods: Adult Sprague-Dawley rats were randomized to four groups: sham+normothermia (sham+NT), sham+hypothermia (sham+HT), TBI+normothermia (TBI+NT) TBI+hypothermia (TBI+HT). The sham+HT TBI+HT groups submitted 32°C for 6 hours. regional cerebral blood flow (rCBF) was assessed 24 hours after TBI; 48...
With the growing popularity of modularity in software development comes rise package managers and language ecosystems. Among them, npm stands out as most extensive manager, hosting more than 2 million third-party open-source packages that greatly simplify process building code. However, this openness also brings security risks, evidenced by numerous poisoning incidents. In paper, we synchronize a local cache containing 3.4 near real-time to give us access code details. Further, perform...
Hyperoxia therapy for acute lung injury (ALI) may unexpectedly lead to reactive oxygen species (ROS) production and cause additional ALI. Calcitonin gene‑related peptide (CGRP) is a 37 amino acid neuropeptide that regulates inflammasome activation. However, the role of CGRP in DNA damage during hyperoxia unclear. Therefore, aim present study was investigate effects on cell death alveolar epithelial type II cells (AEC II) exposed 60% oxygen. AEC were isolated from 19‑20 gestational day fetal...
Prokineticin 2 (PK2) is a small 8 kDa protein that participates in many physiological processes, such as angiogenesis, inflammation, and neurogenesis. This experiment investigated the effect of PK2 on high glucose/high palmitic acid-induced oxidative stress, apoptosis, autophagy cardiomyocytes AKT/GSK3 β signalling pathway. H9c2 cells were exposed to normal concentrations (33 mM) glucose acid (150 μ M) with or without (10 nM) for 48 h. Reactive oxygen species detected using fluorescent...
Ample clinical case reports suggest a high incidence of cardiomyopathy in diabetes mellitus (DM). Recent evidence supports an essential role trehalose (TLS) cardiomyocyte survival signaling. Our previous study found that prokineticin2 (PK2) was involved the process diabetic (DCM). The present examined protective effects and mechanisms TLS on DM‐induced injury mice H9c2 cardiomyocytes. C57BL/6J were intraperitoneally injected with 50 mg·kg -1 ·d streptozotocin for five consecutive days to...
Extranodal natural killer/T-cell lymphoma (ENKTL) is an extremely rare and aggressive lymphoma. We report interesting case of extranodal in a middle-aged woman which mimicked erythema multiforme. The skin lesions this looked like multiforme due to the tagetoid mucosal erosions. two biopsies from her chest scalp were different. One exhibited characteristics CD4+ CD56+ CD8-mycosis fungoides whereas other biopsy showed classical ENKTL histopathological manifestation with positive CD56,...
This study was to detect the protective effects of Houttuynia cordata extract on damage induced by propofol in hippocampal neuron rats.Propofol-induced injury model and H. administration were conducted. Immunofluorescence immunoblot conducted for effect neuronal activity inflammation detected this model.H. extracts increased activity, reduced propofol-induced levels. also apoptosis. Mechanically, we noticed activated phosphoinositide 3-kinase/AKT pathway suppressed Toll-like receptor...
Objective To study the effect of aralia total saponins on renal function type 2 diabetic mice, and its Bax Bcl-2 protein in tissues, order to provide some references for development saponins. Methods The mice were divided into normal group, model positive control low, medium high dose group by random number method. Except others received with high-fat diet one month+one-time large streptozotocin (STZ) induce model, then intragastrically administered same volume saline, was given 1...