A5019156563- Osteoarthritis Treatment and Mechanisms
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Systemic Lupus Erythematosus Research
- Bone Metabolism and Diseases
- Autophagy in Disease and Therapy
- Heme Oxygenase-1 and Carbon Monoxide
- Spinal Cord Injury Research
- Neuroscience of respiration and sleep
- Muscle Physiology and Disorders
- Advanced X-ray and CT Imaging
- Phonocardiography and Auscultation Techniques
- TGF-β signaling in diseases
- Reproductive Biology and Fertility
- Bone health and treatments
- Neuropeptides and Animal Physiology
- Nutrition and Health in Aging
- Sperm and Testicular Function
- Radiomics and Machine Learning in Medical Imaging
- Facial Trauma and Fracture Management
- Muscle metabolism and nutrition
- Histone Deacetylase Inhibitors Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Shoulder Injury and Treatment
- Epilepsy research and treatment
Second Affiliated Hospital of Fujian Medical University
2015-2024
Fujian Medical University
2015-2024
University of California, San Francisco
2021
Xuzhou Central Hospital
2016
Pelvic bone tumors represent a harmful orthopedic condition, encompassing both benign and malignant forms. Addressing the issue of limited accuracy in current machine learning algorithms for tumor image segmentation, we have developed an enhanced segmentation algorithm. This algorithm is built upon improved full convolutional neural network, incorporating fully network (FCNN-4s) conditional random field (CRF) to achieve more precise segmentation. The was employed conduct initial on...
The mechanism by which spinal cord injury (SCI) induces neuronal death has not been thoroughly understood. Investigation on the molecular signal pathways involved in SCI-mediated apoptosis is important for development of new therapeutics SCI. In current study, we explore role heme oxygenase-1 (HO-1) modulation mixed lineage kinase 3/mitogen-activated protein kinase/cJUN N-terminal 3 (MLK3/MKK7/JNK3) signaling, a pro-apoptotic pathway, after We found that MLK3/MKK7/JNK3 signaling was...
Long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1) and growth arrest specific 5 (GAS5) have opposite functions in the apoptosis of chondrocytes, which are involved pathogenesis osteoarthritis (OA). The roles PVT1 GAS5 OA may indicate existence crosstalk between them OA. This study aimed to explore possible interaction Accumulation control synovial fluid samples was measured by RT-qPCR. chondrocytes explored overexpression experiments. Dual-luciferase reporter assay...
Abstract Background： Single-cell RNA sequencing (scRNA-seq) was recently adopted for exploring molecular programmes and lineage progression patterns of pathogenesis important diseases. In this study, we use scRNA-seq to identify potential markers chondrocytes in osteoarthritis (OA) explore the function different types OA. Methods： Here aimed identifies biomarkers differentiation chondrocyte by seq analysis. GO KEGG analysis were used prove candidate marker genes . Protein–protein interaction...
The aim of the study was to analyze effect ABCB1 genetic polymorphisms on efficacy phenytoin (PHT) treatment in epilepsy patients. In total, 200 patients who were administered PHT divided into responsive and pharmaco-resistance groups depending clinical data serum concentration detected by high-performance liquid chromatography (HPLC). analyzed polymerase chain reaction restriction-fragment length polymorphism method. C1236T, C3435T G2677T/A haplotypes reconstructed for gene using SHEsis...
Abstract Background: Single-cell RNA sequencing (scRNA-seq) was recently adopted for exploring molecular programmes and lineage progression patterns of pathogenesis important diseases. In this study, scRNA-seq used to identify potential markers chondrocytes in osteoarthritis (OA) explore the function different types OA. Methods: Here we aimed biomarkers differentiation chondrocyte by seq analysis. GeneOntology ( GO) Kyoto Encyclopedia Genes Genomes (KEGG) analysis were candidate marker genes...
Macrophages are one of the important cells in immune system. In this article, we aim to explore regulatory role miR-455-3p on proliferation and osteoblast differentiation RAW264.7 cells.Expression levels genes proteins were tested via qRT-PCR western blot. The targeted correlation between PTEN was identified by luciferase analysis. MTT assay flow cytometry applied detect apoptosis cells. Osteoclastogenesis completed stimulating RAW 264.7 with RANKL. Tartrate-resistant acid phosphatase (TRAP)...
As an active and predominant blood leukocyte population, granulocytes infiltrate into injured spinal cord produce pro-inflammatory mediators to aggravate neuroinflammation. In the current study, we identify role of T1R1/T1R3 receptor in granulocyte-mediated neuroinflammation a rat injury (SCI) model. We found that T1R1 T1R3 were substantially expressed both circulating infiltrating granulocytes. vitro stimulation with L-serine notably reduced production reactive oxygen species (ROS) several...
Abstract Dysregulation of osteoblastic differentiation is an important risk factor osteoporosis, the therapy which challenging. Dehydrocostus lactone (DHC), a sesquiterpene isolated from medicinal plants, has displayed anti‐inflammatory and antitumor properties. In this study, we investigated effects DHC on mineralization MC3T3‐E1 cells. Interestingly, found that increased expression marker genes differentiation, such as alkaline phosphatase (ALP), osteocalcin (OCN), osteopontin (OPN)....
To investigate the short-term effectiveness of modified tarsal sinus approach and traditional in treatment Sanders Ⅱ-Ⅲ type calcaneal fractures.Between January 2015 August 2017, 53 patients with fractures were selected divided into observation group (21 cases, using for fracture reduction after exposure subtalar joint below long short fibular tendon) control (32 approach) by random number method. There was no significant difference between two groups terms gender, age, side, cause injury,...
Abstract Background： Single-cell RNA sequencing (scRNA-seq) was recently adopted for exploring molecular programmes and lineage progression patterns of pathogenesis important diseases. In this study, scRNA-seq used to identify potential markers chondrocytes in osteoarthritis (OA) explore the function different types OA. Methods： Here we aimed biomarkers differentiation chondrocyte by seq analysis. GeneOntology ( GO) Kyoto Encyclopedia Genes Genomes (KEGG) analysis were candidate marker genes...
Abstract Purpose To investigate the feasibility and reliability of pulse oximeter (POX) as a fast-screening device for congenital heart disease (CHD) through comparing performances cardiac auscultation POX in large retrospective single center study. Methods Every newborn received tests separately. When an abnormal murmur or SpO 2 level is detected, echocardiogram will be ordered to confirm diagnosis CHD newborn. Results From January 1, 2018 December 31, 2019, there were 44,147 livebirths at...