A5038987580- Intracranial Aneurysms: Treatment and Complications
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Neurogenesis and neuroplasticity mechanisms
- Circular RNAs in diseases
- Mesenchymal stem cell research
- Nanoparticle-Based Drug Delivery
- Traumatic Brain Injury and Neurovascular Disturbances
- RNA Interference and Gene Delivery
- Angiogenesis and VEGF in Cancer
- Vascular Malformations Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Education and Learning Interventions
- Digital Mental Health Interventions
- Social Robot Interaction and HRI
- PI3K/AKT/mTOR signaling in cancer
- Cerebrovascular and Carotid Artery Diseases
- Neurological Disease Mechanisms and Treatments
- Stroke Rehabilitation and Recovery
- Neurological Disorders and Treatments
- Nanoplatforms for cancer theranostics
- Intraoperative Neuromonitoring and Anesthetic Effects
- Axon Guidance and Neuronal Signaling
Southern Medical University
2019-2025
Framingham Heart Study
2025
TCM-Intigrated Cancer Center of Southern Medical University
2019-2024
Zhongda Hospital Southeast University
2013-2024
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2023
Southeast University
2013-2022
Zhongshan Hospital of Xiamen University
2007-2011
Chinese PLA General Hospital
2010
Xiamen University
2009
Fujita Health University
2007
Glioblastoma multiforme (GBM) is the most lethal brain malignancy which involves multi‐gene abnormality. Unfortunately, effective therapy against GBM remains lacking. Previously, we found that NRP‐1 and its downstream NRP‐1/GIPC1 pathway played an important role in GBM. In our study, further investigated upstream signaling of to understand how it regulated. First, identified hsa‐miR‐124‐3p was miRNA differentially expressed normal tissues by high‐throughput sequencing. Then, dual luciferase...
Transplanted neural stem cells promote tissue regeneration and functional recovery primarily by releasing paracrine factors. Exosomes act as important secreted molecules to deliver therapeutic agents involved in cellular functions. Here, we focused on the role of exosomes (hNSC-Exo) derived from human (hNSCs). We utilized pro-inflammatory factor interferon gamma (IFN-γ) induce generation altered (IFN-γ-hNSC-Exo), compared their roles with those hNSC-Exo explored potential mechanism....
Our previous study demonstrated the potential therapeutic role of human neural stem cell-derived exosomes (hNSC-Exo) in ischemic stroke. Here, we loaded brain-derived neurotrophic factor (BDNF) into derived from NSCs to construct engineered (BDNF-hNSC-Exo) and compared their effects with those hNSC-Exo on stroke both vitro vivo. In a model H2O2-induced oxidative stress NSCs, BDNF-hNSC-Exo markedly enhanced cell survival. rat middle cerebral artery occlusion model, not only inhibited...
Using engineered exosomes produced from stem cells is an experimental therapeutic approach for treating brain diseases. According to reports, preclinical research has demonstrated notable neurogenesis and angiogenesis effects using modified cell-derived exosomes. These biological nanoparticles have a variety of anti-apoptotic, anti-inflammatory, antioxidant properties that make them very promising nervous system disorders.
Abstract A significant number of nucleic acid therapies have been approved, highlighting the vast potential therapeutics. Although numerous delivery strategies investigated, and progress has made in systems, oral route still presents a obstacle. Recently, novel promising force emerged, namely Decoctosomes Bencaosomes, obtained from decoction natural herbs, which refers to boiled Chinese herbal medicines. The active components include small molecules, peptides, RNAs (sRNAs). sRNAs were first...
Abstract Our objective was to determine the molecular mechanisms by which lncRNA HOXA‐AS3 regulates biological behaviour of glioblastoma multiforme (GBM). We used an microarray assay identify GBM‐related expression profiles. Qrt‐PCR survey levels long non‐coding RNA (lncRNA) and target gene. Dual‐luciferase reporter assays were investigate interaction HOXA‐AS3, gene miRNA. Western blot analysis examine USP3 epithelial‐mesenchymal transition (EMT) genes. The MTT assay, transwell wound healing...
Breakthroughs with rapid changes are the themes of development in Neurorestoratology this year. Given very difficult circumstances persistent COVID-19 pandemic, most colleagues have conducted meaningful research and obtained encouraging results, as described 2020 Yearbook Neurorestoratology. Neurorestorative progress during 2021 depicts recent findings on pathogenesis neurological diseases, neurorestorative mechanisms clinical therapeutic achievements. The risk factors Alzheimer's disease...
Introduction: The neurological impairment of survivors after ischemic stroke poses a serious risk to their quality life and health. Effective therapeutic options are still lacking. Neural stem cells (NSCs) promote neurogenesis via secreted extracellular vesicles (NSC-EVs), which would be potential option, but the insufficient quantity NSC-EVs in vivo restrains clinical application. Buyang Huanwu Decoction (BHD), classic traditional Chinese medicine (TCM) decoction, is promising alleviate...
Soft-growing robots (i.e., vine robots) are a promising class of soft that allow for navigation and growth in tightly confined environments. However, these remain challenging to model control due the complex interplay inflated structure inextensible materials, which leads obstacles autonomous operation design optimization. Although there exist simulators systems have achieved qualitative quantitative success matching high-level behavior, they still often fail capture realistic robot shapes...
Robust COVID-19 outcomes classification is important for ongoing epidemiology research on acute and post-acute conditions. Protocolized medical record review an established method to validate endpoints clinical trials cardiovascular cohorts; however, a protocol adjudicate hospitalizations among cohorts was lacking. We developed ascertain hospitalized across meta-cohort of 14 US prospective cohort studies. This report describes the first three years implementation (October 1, 2020-October...
Stroke has significantly contributed to the global mortality rate over years, emphasizing urgency of finding effective treatment strategies. Neural stem cell (NSC)-derived exosomes have potential improve neurological recovery after stroke; however, their therapeutic efficacy is hindered by rapid clearance and limited duration action. This study presents an innovative drug delivery method: a hydrogel based on NSC hydroxypropyl methylcellulose (HPMC), which intended offer continuous release,...
Stroke recovery is associated with neural stem cell (NSC) development and neurovascular unit reconstruction. The exosome, as an important intercellular player in communication, mediates neuro-restorative events by transferring exosomal protein RNA cargoes. In this study, we explored the role of microRNAs (miRNAs) human NSCs (hNSCs), analyzed expression profiles miRNAs hNSC-derived hypoxic preconditioning exosomes help next generation sequencing (NGS). results demonstrated that a certain...