A5100386283- Diabetes Treatment and Management
- Thyroid Cancer Diagnosis and Treatment
- Thyroid Disorders and Treatments
- Pancreatic function and diabetes
- Diabetes Management and Research
- Long-Term Effects of COVID-19
- Growth Hormone and Insulin-like Growth Factors
- Radiomics and Machine Learning in Medical Imaging
- Hormonal Regulation and Hypertension
- Diet, Metabolism, and Disease
- Metabolism, Diabetes, and Cancer
- Mast cells and histamine
- Diabetic Foot Ulcer Assessment and Management
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- COVID-19 and Mental Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Head and Neck Anomalies
- Thyroid and Parathyroid Surgery
- COVID-19 Clinical Research Studies
- Estrogen and related hormone effects
- Diet and metabolism studies
- Diabetes Management and Education
- Adrenal and Paraganglionic Tumors
- Diabetes and associated disorders
- Natural Antidiabetic Agents Studies
Soochow University
2022-2025
Second Affiliated Hospital of Soochow University
2022-2025
University of Oklahoma Health Sciences Center
2018-2025
Renji Hospital
2025
Shanghai Jiao Tong University
2025
Shenzhen Third People’s Hospital
2014-2025
Beth Israel Deaconess Medical Center
2006-2025
Capital Medical University
2012-2024
Beijing Chao-Yang Hospital
2022-2024
Sichuan University
2024
Background: Papillary thyroid microcarcinoma (PTMC) typically carries an excellent prognosis regardless of the treatment option pursued. Radiofrequency ablation (RFA) for disease has been utilized benign lesions and in patients who are poor surgical candidates cancers with compression symptoms, but efficacy limitations RFA as first-line therapy PTMC not described adequate detail. The purpose our study was to investigate versus thyroidectomy terms efficacy, oncologic outcomes, quality life,...
Growing evidence suggests that symptoms associated with post-COVID-19 condition (also known as long COVID) can affect multiple organs and systems in the human body, but their association viral persistence is not clear. The aim of this study was to investigate SARS-CoV-2 diverse tissues at three timepoints following recovery from mild COVID-19, well its COVID symptoms.
Importance Persistent symptoms and disability following SARS-CoV-2 infection, known as post–COVID-19 condition or “long COVID,” are frequently reported pose a substantial personal societal burden. Objective To determine time to recovery infection identify factors associated with by 90 days. Design, Setting, Participants For this prospective cohort study, standardized ascertainment of was conducted starting in April 1, 2020, across 14 ongoing National Institutes Health–funded cohorts that...
Inflammation and cancer, two therapeutic areas historically addressed by separate drug discovery efforts, are now coupled in treatment approaches a growing understanding of the dynamic molecular dialogues between immune cancer cells. Agents that target specific compartments system, therefore, not only bring new disease modifying modalities to inflammatory diseases, but also offer avenue therapy disrupting components microenvironment foster tumor growth, progression, evasion, resistance....
The Collaborative Cohort of Cohorts for COVID-19 Research (C4R) is a national prospective study adults comprising 14 established US cohort studies. Starting as early 1971, investigators in the C4R studies have collected data on clinical and subclinical diseases their risk factors, including behavior, cognition, biomarkers, social determinants health. links this pre-coronavirus disease 2019 (COVID-19) phenotyping to information severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)...
Understanding the mechanisms controlling forest carbon accumulation is crucial for predicting and mitigating future climate change. Yet, it remains unclear whether dominance of ectomycorrhizal (EcM) trees influences entire forests. In this study, we analyzed inventory data from over 4000 plots across Northeast China. We find that EcM tree consistently exerts a positive effect on tree, soil, stocks. Moreover, observe these effects are more pronounced during unfavorable conditions, at lower...
Abstract The tumor suppressor gene Syk tyrosine kinase is absent or reduced in invasive breast cancer tissues and cell lines; its loss linked to poor prognosis metastasis. Also, evidence shows that vitro involved regulating proliferation. Here, we show by situ hybridization on tissue sections the of expression progressive during development. Strikingly, already partially lost normal epithelial adjacent lesion. In vivo, proliferation (as measured proliferative index Ki67) increased from...
Antagonism of the glucagon receptor (GCGR) is associated with increased circulating levels glucagon-like peptide-1 (GLP-1). To investigate contribution GLP-1 to antidiabetic actions GCGR antagonism, we administered an anti-GCGR monoclonal antibody (mAb B) wild-type mice and knockout (GLP-1R KO) mice. Treatment mAb B lowered fasting blood glucose, improved glucose tolerance, enhanced glucose-stimulated insulin secretion during intraperitoneal tolerance test (ipGTT). In contrast, treatment...
Abstract Background Chronic lymphocytic thyroiditis (CLT) is an autoimmune disease commonly associated with papillary thyroid carcinoma characterized by a smaller primary tumor size at presentation. The efficacy and safety of ultrasound‐guided radiofrequency ablation (RFA) for microcarcinoma (PTMC) coexisting CLT still unknown. Methods Sixty patients unifocal PTMC were enrolled classified into PTMC+CLT groups (n = 30/group). was diagnosed histopathologically. area exceeded the margins,...
Attention-deficit/hyperactivity disorder (ADHD) is one of the most prevalent psychiatric disorders that affects children and even continues into adulthood. Dexmedetomidine (DEX), a short-term sedative, can selectively activate α2-adrenoceptor. Treatment with α2-adrenergic agonists in patients ADHD becoming increasingly common. However, therapeutic potential DEX for treatment unknown. Here, we evaluated effect on ADHD-like behavior spontaneously hypertensive rats (SHRs), widely used animal...
Objective: In this pilot-study, the effects of a multispecies probiotic supplement on glycaemic control and metabolic parameters in adults with type 1 diabetes (T1DM) were explored. Material Methods: A total 50 T1DM patients enrolled randomly placed into group receiving capsules containing multi-probiotic strains ( Bifidobacterium longum , Lactobacterium bulagricumi Streptococcus thermophilus ) insulin (probiotics group, n = 27) or placebo (placebo 23). All underwent continuous glucose...
Thyroid cancer is a leading endocrine malignancy, with anaplastic and medullary subtypes posing treatment challenges. Existing therapies have limited efficacy, highlighting need for innovative approaches.
In our series of patients with primary aldosteronism, we compared diagnostic concordance and clinical outcomes after adrenalectomy between adrenal venous sampling (AVS) computed tomography (CT) imaging. Our retrospective analysis included 886 aldosteronism diagnosed in hospital 2005 2014. Of them, 269 CT unilateral disease were the on 126 follow-up data adrenalectomy. Hypertension was considered cured if systolic/diastolic blood pressure (BP) controlled (<140/90 mm Hg) without medication...
Background: The urgency of the 2019 novel coronavirus outbreak has led to demand effective antiviral agents. Preliminary experiment indicated that Arbidol concentrations might inhibit replication in vitro. However, there was limited data about clinical efficacy coronavirus-infected pneumonia (NCP). Methods: We did a retrospective cohort study NCP patients who received empiric al regimens with or without Arbidol. A total 111 from two centers China were enrolled. Findings: Among these...
Differentiation between follicular thyroid carcinomas (FTCs) and adenomas (FTAs) is difficult the sonographic features of FTC are not yet fully established. The purpose this study to explore value sonography in differentiating FTCs from FTAs.A total 28 pathologically proven 53 FTAs 78 patients who were performed surgery included retrospective study. each tumor including an interrupted halo, satellite nodule(s) with or without halo ring, local irregularity margin cluster grapes sign...
Background Systemic inflammation, aging, and type 2 diabetes (T2D) lead to varying degrees of cardiovascular dysfunction impaired aerobic exercise capacity. This study evaluates the impact inflammation sex differences on coronary peripheral vascular function capacity in older individuals with without T2D. Methods Older (aged≥65 years) underwent biochemical tissue inflammatory phenotyping, cardiopulmonary testing, magnetic resonance imaging, reactivity testing. Correlation regression analyses...
Abstract Objectives The aim of this study was to determine the status tertiary lymphoid structures (TLSs) using radiomic features in patients with invasive pulmonary adenocarcinoma (IA). Methods In retrospective study, IA from November 2015 March 2024 were recruited two independent centers (center 1, training and internal test data set; center 2, external set). TLS divided into groups according hematoxylin-eosin staining. Radiomic extracted, support vector machine (SVM) implemented predict...
Robust COVID-19 outcomes classification is important for ongoing epidemiology research on acute and post-acute conditions. Protocolized medical record review an established method to validate endpoints clinical trials cardiovascular cohorts; however, a protocol adjudicate hospitalizations among cohorts was lacking. We developed ascertain hospitalized across meta-cohort of 14 US prospective cohort studies. This report describes the first three years implementation (October 1, 2020-October...