Background: Papillary thyroid microcarcinoma (PTMC) has a high incidence and good prognosis. Surgical operation for all PTMC might be an overtreatment. The objective of this study was to evaluate the efficacy safety ultrasound (US)-guided radiofrequency ablation (RFA) treating low-risk PTMC. Methods: Ninety-eight in 92 patients were included study. US contrast-enhanced (CEUS) examinations performed before ablation. RFA using moving-shot technique. area exceeded tumor edge prevent marginal...

Background: Papillary thyroid microcarcinoma (PTMC) typically carries an excellent prognosis regardless of the treatment option pursued. Radiofrequency ablation (RFA) for disease has been utilized benign lesions and in patients who are poor surgical candidates cancers with compression symptoms, but efficacy limitations RFA as first-line therapy PTMC not described adequate detail. The purpose our study was to investigate versus thyroidectomy terms efficacy, oncologic outcomes, quality life,...

Abstract Berberine is an isoquinoline alkaloid widely used in the treatment of microbial infections. Recent studies have shown that berberine can enhance inhibitory efficacy antibiotics against clinical multi-drug resistant isolates methicillin-resistant Staphylococcus aureus (MRSA). However, underlying mechanisms are poorly understood. Here, we demonstrated sub-minimum concentrations (MICs) exhibited no bactericidal activity MRSA, but affected MRSA biofilm development a dose dependent...

Background: Thermal ablation (TA) has been applied in patients with low-risk papillary thyroid microcarcinoma (PTMC) who refuse surgery or active surveillance (AS). Recently, TA proposed as a potential therapeutic option for are suitable AS. However, the clinical outcomes of versus remains controversial because lack sufficient data. This study aimed to compare between radiofrequency (RFA) lobectomy (TL) PTMC large cohort. Methods: retrospective evaluated 884 unifocal treated TL RFA from June...

Radiofrequency ablation (RFA) has gained increasing interest as a minimally invasive procedure to treat low-risk papillary thyroid carcinoma (PTC). Considering the indolent nature of this disease, studies in large populations with long follow-up would be invaluable further substantiate effectiveness RFA.

To report more than 5-year outcomes of ultrasound-guided thermal ablation (TA) for patients with solitary low-risk papillary thyroid microcarcinoma (PTMC) in a large multicenter cohort.TA, including radiofrequency (RFA) and microwave (MWA) have been used PTMC who refuse surgery or active surveillance. However, its clinical value remains controversial.This retrospective study included 474 treated TA (357 RFA; 117 MWA) from 4 centers followed up at least 5 years. Disease progression lymph node...

A detailed investigation of the absorption and CD signals Ag(I)−cysteine (Cys) aqueous solutions at buffered or varying pH has allowed us to suggest that coordination polymers are formed upon mixing Ag(I) Cys bearing a Ag(I)−Cys repeat unit. The formation shown be facilitated by both Ag(I)···Ag(I) interaction between side chains in polymeric backbone. former allows for an immediate spectral sensing with enantiomeric discrimination capacity high sensitivity selectivity, contribution...

Abstract: In the current study, we synthesized prostate cancer-targeting poly(lactide- co -glycolic acid) (PLGA) nanobubbles (NBs) modified using A10-3.2 aptamers targeted to prostate-specific membrane antigen (PSMA) and encapsulated paclitaxel (PTX). We also investigated their impact on ultrasound (US) imaging therapy of cancer. PTX-A10-3.2-PLGA NBs were developed water-in-oil-in-water (water/oil/water) double emulsion carbodiimide chemistry approaches. Fluorescence together with flow...

Purpose To evaluate the safety and efficacy of ultrasound-guided RFA for treatment papillary thyroid microcarcinoma (PTMC).Materials methods The data 204 nodules from 198 PTMC patients who were treated using retrospectively reviewed in this study. Demographic variables, complication details CEUS results different time points collected. volumes volume reduction rate (VRR) ablated area under at follow-up calculated compared.Results All successfully without major complication. Mild...

<strong>BACKGROUND</strong> The diagnosis of thyroid cancer and distinguishing benign from malignant nodules by junior radiologists can be challenging. This study aimed to develop a computer-aided (CAD) system based on the Thyroid Imaging Reporting Data System (TI-RADS) distinguish analyzing ultrasound images improve diagnostic performance radiologists. <strong>MATERIAL AND METHODS</strong> A modified TI-RADS convolutional neural network (CNN) was used CAD system. retrospective reviewed 789...

Objective: Papillary thyroid microcarcinoma (PTMC) has a good prognosis and longterm survival, the health-related quality of life (HRQoL) is vital for PTMC survivors during their entire survivorship. Ultrasound (US)-guided radiofrequency ablation (RFA) been introduced as an alternative to surgery patients with low-risk high efficacy safety. However, assessment QoL not specially reported. The aim this study was compare HRQoL between underwent RFA surgery. Methods: From October 2019 December...

BACKGROUND:The aim of this study was to investigate the accuracy contrast-enhanced ultrasound (CEUS) enhancement patterns in assessment thyroid nodules. MATERIAL AND METHODS:A total 158 patients with suspected cancer underwent conventional (US) and CEUS examinations. The contrast lesions, including peripheries were assessed by scans. relationship between size lesions degree also studied. US- and/or CEUS-guided biopsy used obtain specimens for histopathological diagnosis. RESULTS:The final...

Abstract Objective Ultrasonography‐guided radiofrequency ablation (RFA) has been used to treat low‐risk small papillary thyroid carcinoma (PTC) and yielded promising results. However, little research conducted on the application of RFA for management T1bN0M0 PTC. Therefore, this study was compare midterm outcome with that surgery treatment clinical solitary Design This is a retrospective study. Patients In total, 182 patients PTC between April 2014 May 2019 were treated or ( n = 91/group)....

Abstract Background Prediction of lymph node metastasis (LNM) is critical for individualized management papillary thyroid carcinoma (PTC) patients to avoid unnecessary overtreatment as well undesired under-treatment. Artificial intelligence (AI) trained by ultrasound (US) may improve prediction performance. Methods From September 2017 December 2018, with suspicious PTC from the first medical center Chinese PLA general hospital were retrospectively enrolled pre-train multi-scale, multi-frame,...

Forkhead box M1 (FoxM1) transcription factor is related to the pathogenesis of various malignancies and recent evidence indicates that FoxM1 promotes epithelial-mesenchymal transition (EMT) in breast cancer. Metformin can inhibit progression However, whether plays a role EMT prostate cancer (PCa) metformin suppress through PCa remain unresolved issues. In this study, we investigated expression levels protein 62 39 benign hyperplasia (BPH) samples found were higher tissues (66.1%) compared...

Ultrasonography-guided radiofrequency ablation (RFA) is used to treat small low-risk papillary thyroid carcinoma (PTC) and has achieved favorable results. However, few studies have compared the outcomes of T1aN0M0 T1bN0M0 PTC treated with ultrasonography-guided RFA. The objective this study was compare patients receiving RFA for solitary retrospectively.Patients or between April 2014 December 2019 were retrospectively reviewed. All ineligible refused surgery. Our institutional review board...

Purpose To evaluate the efficacy and safety of ultrasonography (US)-guided radiofrequency ablation (RFA) for treating low-risk T1bN0M0 papillary thyroid cancer (PTC).Methods This retrospective study was approved by ethics committee Chinese People's Liberation Army General Hospital (S2019-211-01). Sixty-six patients with PTC (14 men 52 women a mean age 41.0 ± 9.2 years [range, 21–61 years]), who were not eligible or refused surgery, included in our study. RFA performed moving-shot technique,...

Purpose To determine a novel quantitative index, residual vital ratio(RVR) by contrast-enhanced ultrasound(CEUS) with conventional Ultrasound(US), to early predict nodule regrowth after radiofrequency ablation (RFA)for benign thyroid nodules.Methods This retrospective study evaluated 186 patients 206 nodules underwent RFA. Patients were followed at 1, 3, 6, 12 months and every thereafter US, CEUS clinical evaluation. RVR was defined as the initial ratio of volume total calculated US first...

Background: The criteria for determining technical efficacy of thermal ablation papillary thyroid carcinoma (PTC) are not clearly defined. We analyzed the involution process zone with clear pathologic results on core-needle biopsy (CNB) to clarify relationship between sonographic changes and findings. Methods: This retrospective cohort study included 382 patients unifocal T1N0M0 PTC who underwent radiofrequency (RFA) May 2014 August 2021. Patients a single (recommended at 3 or 6 months T1a...