A5073889377- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Glycogen Storage Diseases and Myoclonus
- Genetics and Neurodevelopmental Disorders
- Mesenchymal stem cell research
- Lysosomal Storage Disorders Research
- Neurological diseases and metabolism
- Nuclear Receptors and Signaling
- Carbohydrate Chemistry and Synthesis
- Pharmacological Effects of Natural Compounds
- Genetic Neurodegenerative Diseases
- Tryptophan and brain disorders
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Aluminum toxicity and tolerance in plants and animals
- Pain Management and Treatment
- Phosphodiesterase function and regulation
- Bone and Dental Protein Studies
- Skin and Cellular Biology Research
- Alzheimer's disease research and treatments
- Stroke Rehabilitation and Recovery
- Intracerebral and Subarachnoid Hemorrhage Research
- Glioma Diagnosis and Treatment
- Genetic and rare skin diseases.
- Pluripotent Stem Cells Research
Foshan Hospital of TCM
2025
Weifang Medical University
2024
Liaocheng People's Hospital
2014-2024
Liaocheng University
2018-2024
Shandong University of Traditional Chinese Medicine
2020-2024
Yidu Central Hospital of Weifang
2024
Imam Khomeini Hospital
2023
Tehran University of Medical Sciences
2023
Shandong University
2023
Qingdao University
2019
Multiple genes have been now identified as causing Parkinson's disease (PD). In 2003, two mutations were in exon 1 of the Nurr1 gene 10 107 individuals with familial PD. To date, investigators only focused on screening for these known gene. All recruited from clinics Canada. Following PCR amplification each gene, samples underwent denaturing high-performance liquid chromatography (DHPLC) analysis. Ten also direct sequencing well any where variants identified. The was evaluated 202 PD...
There was much progress in the field of Neurorestoratology year 2022. It included highlighting advances understanding pathogenesis neurological diseases, neurorestorative mechanisms, and clinical treatments as compiled 2022 yearbook Neurorestoratology. is still controversy about whether amyloid β-protein tau protein deposition are reasons for or results Alzheimer's disease (AD) pathology. The fabricated images important key articles that speculated on AD were found. Cholinergic deficiency...
<b><i>Objective: </i></b> Inherited myoclonus-dystonia (IMD) is a new term for an autosomal dominant disorder characterized by myoclonus and dystonia. Recently, IMD was linked to region on chromosome 11q23 with two different mutations identified in the D2 dopamine receptor gene 7q five loss-of-function ε-sarcoglycan gene. <b><i>Methods: These regions genes were excluded large Canadian family whom 13 individuals are affected. A 25-cM genome scan of this 32 performed. <b><i>Results: Two-point...
Objective: To investigate the clinicopathological and genetic features of infantile rhabdomyofibrosarcoma (IRFS) with EGFR kinase domain duplication (EGFR-KDD). Methods: The clinical, morphological immunohistochemical three IRFS EGFR-KDD diagnosed from January 2022 to 2024 at Department Pathology, Foshan Traditional Chinese Medicine Hospital, Foshan, China were retrospectively analyzed using PCR or next generation sequencing technique; related literature was reviewed. Results: There 1 male 2...
Inherited myoclonus dystonia (MD) is an autosomal dominant disorder in which we previously mapped a novel locus to chromosome18p11 (OMIM number: 607488). Since no further informative STS markers were found within the flanking shared regions, utilized single nucleotide polymorphisms (SNP) for fine-mapping. All known or predicted genes this region directly sequenced. We identified three recombinant SNPs distal but none from proximal region. Our previous linked has now been reduced 3.18 Mb...
Myoclonus-dystonia syndrome (MDS) is a disorder for which the major cause appears to be mutations in epsilon-sarcoglycan gene (SGCE). The authors have now performed mutation screening 22 affected individuals from seven families with findings of typical MDS. A novel 5-bp deletion exon 7 one family and previously reported R102X nonsense 3 two other were identified. Mutations SGCE found minority screened this series.
Background: Mutations in the β-glucocerebrosidase gene (GBA) have been implicated as a risk factor for Parkinson's disease (PD). However, GBA mutations PD patients of different ethnic origins were reported to be inconsistent. Methods: We sequenced all exons 225 and 110 control individuals from Eastern Canada. Result: Two novel variants c.-119 A/G S(-35)N, five known R120W, N370S, L444P, RecNciI RecTL mutation (del55/D409H/RecNciI) well two non-pathological E326K T369M identified while only...
Protein arginine deiminase 3 (PADI3) is involved in various biological processes of human disease. PADI3 has recently received increasing attention due to its role tumorigenesis. In a previous study, we found that plays tumor suppressor colon cancer by inducing cell cycle arrest, but critical and mechanism metastasis remain obscure. this fully studied the metastasis.
Bone marrow stromal cells (BMSCs) may differentiate into nerve under a certain condition; however, the clinical application for treating nervous system disease remains unclear. The aim is to assess safety profile, feasibility, and effectiveness of surgery combined with autologous BMSCs transplantation ICH. 206 ICH patients who had received surgical procedure were divided (n = 110) or control group 96). For group, injected perihemorrhage area in base ganglia through an intracranial drainage...
// Yabing Dong 1, 2, * , Gaoyi Wu 3, Ting Zhu Hongyu Chen 2 Yong Guoxiong 3 Fabin Han 4 Huaqiang Zhao 1 School of Stomatology, Shandong University, Wen Hua Xi Lu, Jinan City 250012, Province, China Provincial Key Laboratory Oral Tissue Regeneration, Department Military General Hospital, Shi Fan 250031, Center for Stem Cells and Regenerative Medicine, The Affiliated Liaocheng Taishan Medical 252000, These authors contributed equally to this work Correspondence to: Zhao, email:...
Time is infinite movement in constant motion. We are glad to see that Neurorestoratology, a new discipline, has grown into rich field involving many global researchers recent years. In this 2019 yearbook of we introduce the most advances and achievements field, including findings on pathogenesis neurological diseases, neurorestorative mechanisms, clinical therapeutic globally. Many patients have benefited from treatments cell therapies, neurostimulation/neuromodulation, brain–computer...
Neural progenitor cells (NPCs) have great potentials in cell replacement therapy for neurodegenerative diseases, such as Alzheimer's disease (AD), by promoting neurogenesis associated with hippocampal memory improvement. Ephrin receptors and angiogenic growth factor a marked impact on the proliferation differentiation of NPCs. Although ephrin receptor A4 (EphA4) was shown to directly interact platelet-derived β (PDGFRβ), functional effects this interaction cultured NPCs adult hippocampus not...
Cell therapy has been shown to be a crucial clinical therapeutic option for central nervous system diseases or damage. Promoting standardization of cell procedures is essential professional associations devoted therapy. The International Association Neurorestoratology (IANR) and the Chinese (CANR; Preparatory) collaborated release Clinical Therapy Guidelines Neurorestoration (IANR/CANR 2017) in 2018. Due recent advances achievements worldwide years, IANR CANR have renewed updated guidelines....
Abstract Hereditary chin trembling is a rare autosomal dominant condition that has been linked to chromosome 9q13‐21 in one kindred. We describe four‐generation family with this and, using linkage analysis, have excluded the region as causing family. © 2002 Movement Disorder Society
Abstract Myoclonus‐dystonia (M‐D) (MIM 159900) is a rare “dystonia plus” syndrome, characterized by rapid myoclonic jerks, predominantly in the neck and upper limbs, combination with dystonia. Mutations gene ε‐sarcoglycan ( SGCE ) are known to be responsible for approximately one‐third of cases. We screened 21 probands diagnosed M‐D large deletions who were mutation negative as determined PCR‐direct sequencing. Multiplex PCR quantification products was performed using modified application...
Parkinson's disease (PD) is a highly prevalent and severe neurodegenerative that affects more than 10 million individuals worldwide. Pathogenic mutations in LRP10 have been associated with autosomal dominant PD. Here, we report an induced pluripotent stem cell (iPSC) line generated from PD patient harboring the c.688C > T (p.Arg230Trp) variant. Skin fibroblasts were successfully reprogrammed into iPSCs expressed pluripotency markers, normal karyotype, capacity to differentiate three germ...
This study aimed to investigate the causal relationship between gut microbiota characteristics (207 taxa and 205 pathways) Alzheimer's disease determine quantify role of immune cells as potential mediators.
Background: Mutations in the leucine-rich repeat kinase 2 gene (LRRK2) have become most common known cause for developing Parkinson's disease. The frequency of mutations described literature varies widely depending on population studied with reports focusing only screening G2019S mutation exon 41. Methods: In this study seven exons (19, 24, 25, 31, 35, 38, and 41) LRRK2 where been reported were screened 230 unselected disease patients using denaturing high-performance liquid chromatography....
Background: Recently, a single base pair substitution (G1747A) mutation of the neurofilament M (NF-M) gene was reported in French-Canadian patient with early onset Parkinson’s disease (PD). Three unaffected siblings were found to be heterozygotes for NF-M Gly336Ser but, date, no other affected PD individuals have been similar mutation. No and ethnic background screened this Methods: We 102 patients definite 45 controls using PCR-restriction enzyme digestion method. Results: None or carried...