A5101554920- Bone Tissue Engineering Materials
- Nanoparticle-Based Drug Delivery
- Electrospun Nanofibers in Biomedical Applications
- Spine and Intervertebral Disc Pathology
- RNA Interference and Gene Delivery
- Dendrimers and Hyperbranched Polymers
- Musculoskeletal pain and rehabilitation
- Cellular Mechanics and Interactions
- 3D Printing in Biomedical Research
- Tissue Engineering and Regenerative Medicine
- Tendon Structure and Treatment
- Advanced biosensing and bioanalysis techniques
- Polymer Surface Interaction Studies
- Osteoarthritis Treatment and Mechanisms
- Orthopaedic implants and arthroplasty
- Periodontal Regeneration and Treatments
- DNA and Nucleic Acid Chemistry
- Advanced Polymer Synthesis and Characterization
- Nanoplatforms for cancer theranostics
- Mesenchymal stem cell research
- Sirtuins and Resveratrol in Medicine
- Hippo pathway signaling and YAP/TAZ
- Bone Metabolism and Diseases
- Polymer composites and self-healing
- Carbon and Quantum Dots Applications
Soochow University
2016-2025
Fudan University
2023
State Key Laboratory of Medical Neurobiology
2023
First Affiliated Hospital of Soochow University
2014-2022
Soochow University
2019-2022
The Orthopaedic Institute
2015-2019
Orthopedic Institute
2014-2016
Suzhou Research Institute
2014
Annulus fibrosus (AF) tissue engineering has recently received increasing attention as a treatment for intervertebral disc (IVD) degeneration; however, such remains challenging because of the remarkable complexity AF tissue. In order to engineer functional replacement, fabrication cell-scaffold constructs that mimic cellular, biochemical and structural features native is critical. this study, we fabricated aligned fibrous polyurethane scaffolds using an electrospinning technique used them...
The dynamic extracellular matrix (ECM) constantly affects the behaviors of cells. To mimic dynamics ECM with controllable stiffness and energy dissipation, this study proposes a strategy in which small molecule, 3,4-dihydroxybenzaldehyde (DB), was used as fast "dynamic bridges'' to construct viscoelastic gelatin methacryloyl (GelMA)-based hydrogels. storage modulus loss hydrogels were independently adjusted by covalent crosslinking density number bonds. exhibited self-healing property,...
Intervertebral disc degeneration (IVDD) is one of the main causes low back pain. Although local delivery strategies using biomaterial carriers have shown potential for IVDD treatment, it remains challenging intervention against multiple adverse contributors by a single platform. In present work, we propose new functionalization strategy vanillin, natural molecule with anti-inflammatory and antioxidant properties, to develop multifunctional gelatin methacrylate (GelMA) microspheres...
Reversibly shielded DNA polyplexes based on bioreducible poly(dimethylaminoethyl methacrylate)-SS-poly(ethylene glycol)-SS-poly(dimethylaminoethyl methacrylate) (PDMAEMA-SS-PEG-SS-PDMAEMA) triblock copolymers were designed, prepared and investigated for in vitro gene transfection. Two PDMAEMA-SS-PEG-SS-PDMAEMA with controlled compositions, 6.6-6-6.6 13-6-13 kDa, obtained by reversible addition-fragmentation chain transfer (RAFT) polymerization of dimethylaminoethyl methacrylate (DMAEMA)...
Abstract: Natural and synthetic polymeric materials have been widely used in bone tissue engineering due to their similarity with extracellular matrices considerable biocompatibility biodegradability. A variety of techniques has applied modify the physicochemical, structural, biological properties meet specific requirements regeneration. This review aims provide a brief overview recent progress on synthesis fabrication for engineering. Commonly innovative processing fabricate different...
The behaviors and functions of individual cells, fundamental to the complexity multicellular organisms, are regulated by their integrated response a variety environmental cues such as soluble factors, extracellular matrix (ECM)-mediated signals, cell-cell interactions. Among these cues, biomechanical feature ECM, represented its elasticity, has been increasingly recognized dominating factor cell fate. This review article aims provide an overview general principles recent advances in field...
Cell sheet-based scaffold-free technology holds promise for tissue engineering applications and has been extensively explored during the past decades. However, efficient harvest handling of cell sheets remain challenging, including insufficient extracellular matrix content poor mechanical strength. Mechanical loading widely used to enhance production in a variety types. currently, there are no effective ways apply sheets. In this study, we prepared thermo-responsive elastomer substrates by...
Saccharides and temperature dual-responsive hydrogels have been prepared based on PNIPAAm copolymers containing phenylboronic acid (PBA) groups used for harvesting cell sheets. The sheet could be released from the hydrogel layer at 37 °C simply by increasing sugar concentration, more efficiently a lower elevated concentration.
Osteoarthritis is a chronic degenerative joint disease involving both articular cartilage and subchondral bone. Kartogenin (KGN) was recently identified to improve in vivo repair; however, its effect on bone formation unknown. The aim of this study investigate the KGN antioxidant properties osteogenic differentiation marrow‐derived mesenchymal stem cells (BM‐MSCs). Human BM‐MSCs were treated with at concentrations ranging from 10 −8 M −6 M. Our results indicated that improved cell...
We describe a biodegradable amphiphilic polyurethane (PU) with disulfide bonds in the main chain [PEtOz-b-PU(SS)-b-PEtOz]. This multi-block PU was synthesized using poly (ε-caprolactone) diol (PCL-SS-PCL) and (2-ethyl-2-oxazoline) (PEtOz-OH) as soft segments, bis (2-isocyanatoethyl) hard segment. Acid-sensitive PEtOz-OH used hydrophilic segment for pH sensitivity. And reduction sensitivity induced via incorporated into hydrophobic of PUs. The system can self-assemble to form micelles...
The self-repair ability of articular cartilage is limited, which one the most difficult diseases to treat clinically. Kartogenin (KGN) induces chondrogenesis by regulating RUNX1 mRNA translation and small molecule compound TD-198946 (TD) promotes chondrogenic differentiation mesenchymal stem cells (MSCs) through increasing transcription mRNA. GelMA hydrogel liposomes are respectively similar extracellular matrix (ECM) vesicles (EVs). So, we developed an "EVs-in-ECM" mimicking system...
Abstract A versatile family of cationic methacrylate copolymers containing varying amounts primary and tertiary amino side groups were synthesized investigated for in vitro gene transfection. Two different types copolymers, poly(2‐(dimethylamino)ethyl methacrylate)/aminoethyl [P(DMAEMA/AEMA)] methacrylate)/aminohexyl [P(DMAEMA/AHMA)], obtained by reversible addition‐fragmentation chain transfer (RAFT) copolymerization dimethylaminoethyl (DMAEMA) with N ‐( tert ‐butoxycarbonyl)aminoethyl...