A5101807225- Nanoplatforms for cancer theranostics
- Extracellular vesicles in disease
- Photoacoustic and Ultrasonic Imaging
- Photodynamic Therapy Research Studies
- Luminescence and Fluorescent Materials
- Nanoparticle-Based Drug Delivery
- Quantum Dots Synthesis And Properties
- Advanced Nanomaterials in Catalysis
- Cancer, Hypoxia, and Metabolism
- Nanocluster Synthesis and Applications
- Molecular Sensors and Ion Detection
- Advanced biosensing and bioanalysis techniques
- Advanced Chemical Sensor Technologies
- Nicotinic Acetylcholine Receptors Study
- Biochemical and Structural Characterization
- Luminescence Properties of Advanced Materials
- Neuroscience and Neuropharmacology Research
- Chemokine receptors and signaling
- Porphyrin and Phthalocyanine Chemistry
- Thermal Regulation in Medicine
- Chemical Synthesis and Analysis
- Ga2O3 and related materials
- Antimicrobial Peptides and Activities
- Food Quality and Safety Studies
- Parasitic infections in humans and animals
Xinjiang Medical University
2021-2025
Chinese Academy of Sciences
2024-2025
Second Affiliated Hospital of Xinjiang Medical University
2024-2025
Wuhan Institute of Physics and Mathematics
2024-2025
Huazhong University of Science and Technology
2025
Wuhan National Laboratory for Optoelectronics
2024-2025
Wuhan University
2022-2023
Global Health Research Center of Central Asia
2021
Urumqi Vocational University
2021
Institute of Scientific and Technical Information of China
2021
Developing a theranostic system that integrates multimodal imaging, synergistic therapeutic, and formulation entities is promising strategy for efficient cancer treatment. However, the complexity safety concerns of multiple functional hinder their clinical translation. Herein, versatile "all-in-one" heptamethine cyanine amphiphiles (PEG-Cy-Fs) with favorable capabilities, including fluorine-19 magnetic resonance imaging (19 F MRI), near-infrared fluorescence (NIR FLI), photodynamic therapy...
Purpose: Indocyanine green (ICG) is a favorable fluorescence nanoprobe for its strong NIR-I emission and good photothermal capabilities. However, the stability tumor targeting ability of ICG poor, which limits further applications. To improve therapeutic efficiency ICG, bovine serum albumin (BSA) was utilized to encapsulate chemotherapeutic drug doxorubicin (DOX) loaded form [email protected] theranostic nanoplatform. Methods: In this study, ICG-loaded BSA nanoparticles (NPs) NPs were...
Microorganisms and cancer have always been the fierce enemies of human beings, but traditional methods treating them still many defects. Therefore, it is extremely important to develop rapid, effective safe treatments. Photodynamic Therapy (PDT) has attracted much attention because its advantages non-invasive, non-drug tolerance, high selectivity low toxicity. As a result, more scientists are committed developing better photosensitizers enhance efficiency PDT in therapy microorganisms as...
Photodynamic therapy (PDT) holds great potential in cancer treatment, leveraging photosensitizers (PSs) to deliver targeted therapy. Fluorination can optimize the physicochemical and biological properties of PSs for better PDT performance. Here, we report some high-performance multifunctional specifically designed by fluorinating aza-BODIPY with perfluoro-tert-butoxymethyl (PFBM) groups. plays several roles, including enhancing selective cell uptake, plasma membrane (PM) targeting, inducing...
Purpose: A synergistic treatment strategy of phototherapy and chemotherapy has been shown to improve efficacy offer unique advantages over monotherapy. The purpose this study is explore a new nanocarrier system with liposome as the inner membrane erythrocyte outer membrane, which aims realize leak-free load drug indocyanine green (ICG) doxorubicin (DOX), prolong circulation time in vivo therapeutic effect. Patients Methods: In study, bilayer membrane-loaded ICG DOX nanoparticles (RBC@ICG-DOX...
Alveolar echinococcosis (AE) is a serious parasitic infectious disease that highly invasive and destructive to the liver has high mortality rate. However, currently, there no effective targeted imaging treatment method for precise detection therapy of AE. We proposed new two-step targeting strategy (TSTS) AE based on poly(lactic-co-glycolic acid) (PLGA). designed constructed novel type ICG@PLGA@Lips nanoprobe with integrated properties. First, we used characteristics PLGA gluconeogenic raw...
Photothermal therapy (PTT) is a popular tumor method, which based on efficient photothermal nanoagents (PTNs). Clinical Indocyanine Green (ICG), as Food and Drug Administration (FDA) approved agent, an often-used PTN, meanwhile it also good near-infrared (NIR) fluorescence contrast agent. However, the further applications of ICG in biomedical fields are limited due to its poor stability. In this study, was encapsulated by amphiphilic polymer poly(styrene-co-maleic anhydride) (PSMA) form...
Photothermal therapy (PTT) is a safe and efficient anti-tumor treatment.
High treatment accuracy is the key to efficient cancer treatment. Photodynamic therapy (PDT) and photothermal (PTT) are two kinds of popular, precise methods. The combination photodynamic (PDT/PTT) can greatly enhance therapeutic efficacy. In this work, protoporphyrin IX (PpIX) was selected as PDT agent (photosensitizer), new indocyanine green (IR-820) PTT agent. Further, theranostic agents were encapsulated by biological-membrane-compatible liposomes form PpIX-IR-820@Lipo nanoparticles...
Although albumin has been extensively used in nanomedicine, it is still challenging to fluorinate into fluorine-19 magnetic resonance imaging (19F MRI)-traceable theranostics because existing strategies lead severe 19F signal splitting, line broadening, and low MRI sensitivity. To this end, 34-cysteine-selectively fluorinated bovine serum albumins (BSAs) with a sharp singlet peak have developed as MRI-sensitive self-assembled frameworks for cancer theranostics. It was found that non-binding...
Photodynamic therapy (PDT) has become a potential anti-cancer strategy owing to its negligible invasiveness, low toxicity, and high selectivity. The photosensitizer (PS) plays an indispensable role in PDT. Herein, novel type of PS (Ce6-MB@Lips) which can be excited by near-infrared (NIR) laser was designed synthesized. Methylene blue (MB) Chlorin e6 (Ce6), two organic dyes approved the Food Drug Administration (FDA), were used prepare Ce6-MB@Lips thin-film dispersion method, improve water...
Smart lipids with fluorescence emission, thermal response, and polyethylene glycolation (PEGylation) functions can be highly valuable for formulation, image-traceable delivery, targeted release of payloads.
Gold (Au) nanorods (NRs) have been extensively used in applications biomedical fields, thanks to their adjustable optical and stable chemical properties. Especially for the photothermal therapy (PTT) of cancer, Au NRs show an excellent thermal effect near-infrared (NIR) light range. However, cetyltrimethylammonium bromide (CTAB), which has traditionally widely synthesis NRs, is generally cytotoxic. Surface modification one ideal nanotechnologies reduce toxicity enhance biocompatibility...
Triple-negative breast cancer (TNBC) is an aggressive and often fatal disease, especially since the brain metastasis of TNBC has been a particularly severe manifestation. However, in at early stages lacks noticeable symptoms, making it challenging to detect. Near-infrared II (NIR-II) fluorescence microscopic imaging obtains long wavelength, which enables reduced scattering, high spatial resolution minimal autofluorescence, also favorable method for tumor diagnosis. PbS@CdS quantum dots (QDs)...
Pioneering approaches for precise tumor removal involve fluorescence-guided surgery, while challenges persist, including the low fluorescence contrast observed at boundaries and potential excessive damage to normal tissue edges. Lead/cadmium sulfide quantum dots (PbS@CdS QDs), boasting high yields (QYs) vivid fluorescence, have facilitated advancements in second near-infrared window (NIR-II, 900–1700 nm). However, during fluorescent surgical navigation operations, hydrophilic coatings of...
Abstract Precise theranostics of tumors is intricately linked to the early detection and monitoring lymph nodes (LN) metastases, making targeted localization LNs essential for tumor identification. However, designing LN‐targeting probes remains a significant challenge due issues such as lymphatic uptake, biocompatibility, fluorescence stability. To address these challenges, near‐infrared II (NIR‐II) are developed through meticulous analysis LN physiological structure passive targeting...
Abstract Photothermal therapy (PTT) has attracted wide attention due to its noninvasiveness and thermal ablation ability. As photothermal agents are crucial factor in PTT, those with the characteristics of biocompatibility, non‐toxicity high stability have great interest. In this work, new indocyanine green (IR‐820) was utilized as a agent near‐infrared (NIR) fluorescence imaging nanoprobe. To improve poly(styrene‐co‐maleic anhydride) (PSMA) encapsulate IR‐820 molecules form novel...
Photothermal therapy (PTT) has attracted extensive attention in cancer treatment due to its non-invasiveness, high efficiency, and repeatability recent years. agents (PTAs) are the key factor for PTT. Recently, although an increasing number of PTAs have been developed, there is still a great demand optimized photothermal nanoparticles (NPs) with low toxicity, bio-safety stability. Herein, new indocyanine green (IR820) near-infrared (NIR:700-1,700 nm) fluorescence emission was selected as...
Near-infrared II (NIR-II, 900-1700 nm) fluorescence bioimaging with advantages of good biosafety, excellent spatial resolution, high sensitivity, and contrast has attracted great attention in biomedical research fields. However, most the nanoprobes used for NIR-II imaging have poor tumor-targeting ability therapeutic efficiency. To overcome these limitations, a novel NIR-II-emissive theranostic nanoplatform treatment cervical cancer was designed prepared. The dye IR-783 chemotherapy drug...
The advent of drones has revolutionized various aspects our lives, and in the realm biological systems, molecular hold immense promise as "magic bullets" for major diseases. Herein, we introduce a unique class fluorinated macromolecular amphiphiles, designed shape jellyfish, serving exemplary fluorine-19 MRI (
Imaging-guided chemo-photothermal combination therapy (chemo-PTT) is recognized for its synergistic therapeutic effects, reduced side and minimal drug resistance, while the development of such theranostics has been hampered by poor imaging performance tedious formulation. Herein, we introduce an all-in-one "add-on" module (BBT-C6) convenient construction doxorubicin (DOX)-loaded nanoparticles (DOX@BBT) efficient second near-infrared (NIR-II) fluorescence (FLI)-guided chemo-PTT drug-resistant...