A5085962078- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Crystallography and molecular interactions
- Neuroscience and Neuropharmacology Research
- Crystal structures of chemical compounds
- Metal-Organic Frameworks: Synthesis and Applications
- Metal complexes synthesis and properties
- Ion channel regulation and function
- Organic Chemistry Cycloaddition Reactions
- Neuroscience and Neural Engineering
- Memory and Neural Mechanisms
- Nicotinic Acetylcholine Receptors Study
- Cellular transport and secretion
- Neural dynamics and brain function
- Oxidative Organic Chemistry Reactions
- Neuroendocrine regulation and behavior
- Hormonal Regulation and Hypertension
- Action Observation and Synchronization
- Polyoxometalates: Synthesis and Applications
- Neurogenesis and neuroplasticity mechanisms
- Synthesis and biological activity
- Fluorine in Organic Chemistry
- Multisensory perception and integration
- Ammonia Synthesis and Nitrogen Reduction
- Protein Tyrosine Phosphatases
Vanderbilt University
2023-2025
Zhejiang University
2005-2023
Shanghai International Studies University
2023
Guizhou Academy of Agricultural Sciences
2022
Shaanxi Normal University
2021
Southeast University
2009
East China Normal University
2009
Early sensory experiences interact with genes to shape precise neural circuits during development. This process is vital for proper brain function in adulthood. Neurological dysfunctions caused by environmental alterations and/or genetic mutation may share the same molecular or cellular mechanisms. Here, we show that early life bilateral whisker trimming (BWT) subsequently affects social discrimination adult male mice. Enhanced activation of hippocampal dorsal CA3 (dCA3) BWT mice was...
Neuronal excitation-transcription (E-T) coupling pathways can be initiated by local increases of Ca 2+ concentrations within a nanodomain close to the L-type voltage-gated channel (LTCC). However, molecular mechanisms controlling LTCC organization plasma membrane that help creation these localized signaling domains remain poorly characterized. Here, we report neuronal depolarization V 1.3 clustering in cultured hippocampal neurons. Our previous work showed binding activated catalytic domain...
Neuroligins (NLs), a family of postsynaptic cell-adhesion molecules, have been associated with autism spectrum disorder. We reported that dysfunction the medial prefrontal cortex (mPFC) leads to social deficits in an NL3 R451C knockin (KI) mouse model autism. However, underlying molecular mechanism remains unclear. Here, we find N-methyl-D-aspartate receptor (NMDAR) function and parvalbumin-positive (PV+) interneuron number expression are reduced mPFC KI mice. Selective knockdown NMDAR...
N-methyl-D-aspartate (NMDA) receptor overactivation is involved in neuronal damage after stroke. However, the mechanism underlying NMDA receptor-mediated excitotoxicity remains unclear. In this study, we confirmed that excessive activation of NMDARs led to cell apoptosis PC12 cells and primary cultured cortical neurons, which was mediated predominantly by GluN2B-containing, but not GluN2A-containing NMDARs. addition, Clathrin-dependent endocytosis participated NMDA-induced excitotoxicity....
Abstract Clustering of L‐type voltage‐gated Ca 2+ channels (LTCCs) in the plasma membrane is increasingly implicated creating highly localized signaling nanodomains. For example, neuronal LTCC activation can increase phosphorylation nuclear CREB transcription factor by increasing concentrations within a nanodomain close to channel, without requiring bulk increases cytosol or nucleus. However, molecular basis for clustering poorly understood. The postsynaptic scaffolding protein Shank3...
Huntingtin-interacting protein 1-related (HIP1R) is considered to be an endocytic adaptor like the other two members of Sla2 family, Sla2p and HIP1. They all contain homology domains responsible for binding clathrin, inositol lipids F-actin. Previous studies have revealed that HIP1R highly expressed in different regions mouse brain localizes at synaptic structures. However, function nervous system remains unknown. In this study, we investigated cultured rat hippocampal neurons using shRNA...
Multi-source data is widely used in the field of energy future prices forecasting, improvement forecast ability and screening are becoming focus current research. In this paper, two tree-based models (namely, Random Forest XGBoost model) employed to predict China's crude oil prices. The empirical analysis confirms that model have superior prediction performances than benchmark performs best. An important finding there a time gap between investor information search processing because...
Huntington-interacting protein 1-related (HIP1R) was identified on the basis of its structural homology with HIP1. Based domain structure, HIP1R is a putative endocytosis-related protein. Our previous study had shown that knockdown induces dramatic decrease dendritic growth and branching in cultured rat hippocampal neurons. However, underlying mechanism remains elucidative. In this study, we found impaired endocytosis activated epidermal factor receptor (EGFR) consequent activation...
The collaborative ability to coordinate an individual with others is critical performance of joint actions. Prior studies found that different types interpersonal situations have more or less impact on the actions, but results are controversial. To clarify influence ability, we adopted Simon task, a choice-reaction task two people perform together. Functional near-infrared spectroscopy (fNIRS) was used study neural mechanisms and under payoffs fostered competition cooperation. fNIRS showed...
The title compound, [Cu(C5H3N2O2)2], was prepared in a water–ethanol solution containing 2-cyanopyrimidine, malonic acid and copper(II) nitrate trihydrate. CuII ion, located on an inversion center, is chelated by two pyrimidine-2-carboxylate anions CuO2N2 square-planar geometry. uncoordinated carboxylate O atom pyrimidine N atoms are linked to adjacent rings via weak C—H⋯O C—H⋯N hydrogen bonding. π–π Stacking observed between nearly parallel rings, the centroid-to-centroid separation...
In addition to cortical areas, the thalamus also displays plasticity during a critical period in early life. Since most sensory information is transmitted cortex via thalamus, it will be of significant interest understand precise time window and underlying mechanisms this thalamus. By using vitro whole-cell patch recording acute brain slices, we found that VPm relay synapses were only sensitive whisker deprivation from postnatal day 11 (P11) P14. Whisker initiated within P11 P14...
The crystal structure of the title compound, [Ni(C7H5O4)(C12H8N2)2(H2O)](C7H5O4)·H2O, consists NiII complex cations, 2,4-dihydroxybenzoate (dHBA) anions and solvent water molecules. cation assumes a distorted octahedral coordination geometry formed by two 1,10-phenanthroline (phen) ligands, one dHBA ion molecule. π–π Stacking is observed between partially overlapped, parallel phen ligands nearly ligand benzene ring dHBA.