A5078773979- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Neuroscience and Neuropharmacology Research
- Cell Image Analysis Techniques
- Neurological disorders and treatments
- Genetics and Neurodevelopmental Disorders
- Protein Tyrosine Phosphatases
- Neurotransmitter Receptor Influence on Behavior
- Photoreceptor and optogenetics research
- MicroRNA in disease regulation
- Parkinson's Disease Mechanisms and Treatments
- Receptor Mechanisms and Signaling
- Nicotinic Acetylcholine Receptors Study
- Memory and Neural Mechanisms
- Transcranial Magnetic Stimulation Studies
- Bioactive Compounds and Antitumor Agents
- Autism Spectrum Disorder Research
- Protein Kinase Regulation and GTPase Signaling
East China Normal University
2023-2024
Salk Institute for Biological Studies
2019-2023
Zhejiang University
2015-2016
Cortico-basal ganglia-thalamocortical loops are largely conceived as parallel circuits that process limbic, associative, and sensorimotor information separately. Whether how these functionally distinct interact remains unclear. Combining genetic viral approaches, we systemically mapped the limbic motor cortico-basal in rodents. Despite closed within each functional domain, discovered a unidirectional influence of over loop via ventral striatum-substantia nigra (SNr)-motor thalamus circuitry....
Parkinson's disease (PD) is a progressive neurodegeneration initially described by James Parkinson. It typically diagnosed based on clinical features such as bradykinesia, resting tremor, rigidity, and, in later stages, postural instability. Epidemiologically, the prevalence of PD ranges from 5 to over 35 cases per 100,000 population, with majority affecting individuals aged 50 years or older. The risk increases age, particularly males. Various factors, including genetics, lifestyle,...
The striatal direct and indirect pathways constitute the core for basal ganglia function in action control. Although both D1- D2-spiny projection neurons (SPNs) receive excitatory inputs from cerebral cortex, whether or not they share same cortical neurons, how pathway-specific corticostriatal projections control behavior remain largely unknown. Here using a new G-deleted rabies system mice, we found that more than two-thirds of to D2-SPNs also target D1-SPNs, while only one-third do so vice...
The striatal direct and indirect pathways constitute the core for basal ganglia function in action control. Although both D1- D2-spiny projection neurons (SPNs) receive excitatory inputs from cerebral cortex, whether or not they share same cortical neurons, how pathway-specific corticostriatal projections control behavior remain largely unknown. Here using a new G-deleted rabies system mice, we found that more than two-thirds of to D2-SPNs also target D1-SPNs, while only one-third do so vice...
The striatal direct and indirect pathways constitute the core for basal ganglia function in action control. Although both D1- D2-spiny projection neurons (SPNs) receive excitatory inputs from cerebral cortex, whether or not they share same cortical neurons, how pathway-specific corticostriatal projections control behavior remain largely unknown. Here using a new G-deleted rabies system mice, we found that more than two-thirds of to D2-SPNs also target D1-SPNs, while only one-third do so vice...