A5100423394- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Neuroscience and Neural Engineering
- Regulation of Appetite and Obesity
- Memory and Neural Mechanisms
- Neurological Disease Mechanisms and Treatments
- Ovarian function and disorders
- Photoreceptor and optogenetics research
- Epilepsy research and treatment
- Sleep and Wakefulness Research
- Biochemical Analysis and Sensing Techniques
- Genetic Associations and Epidemiology
- Hydrogels: synthesis, properties, applications
- Ion channel regulation and function
- Infectious Encephalopathies and Encephalitis
- Cerebrovascular and genetic disorders
- Traffic control and management
- Pharmacovigilance and Adverse Drug Reactions
- Circadian rhythm and melatonin
- Pharmaceutical industry and healthcare
- Biochemical effects in animals
- Pregnancy and preeclampsia studies
- Ovarian cancer diagnosis and treatment
- Cerebrovascular and Carotid Artery Diseases
Qingdao University
2020-2025
Affiliated Hospital of Qingdao University
2020-2025
Xi'an Medical University
2024
Zhejiang University
2017-2022
Zhejiang Lab
2021-2022
Second Affiliated Hospital of Zhejiang University
2021
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2016
Overeating is a serious issue in modern society, causing many health problems, including obesity. Although the hypothalamus has been previously identified as key brain structure that regulates body weight homeostasis, downstream pathways and non-canonical neural circuitry involved feeding behavior remain largely uncharacterized. Here, we discover suppressing activity of GABAergic cells anterior ventrolateral periaqueductal gray (vlPAG), whether directly or through long-projection inputs from...
Abstract Background Observational studies have shown a link between elevated body mass index (BMI) and the risk of polycystic ovary syndrome (PCOS). While Mendelian randomization (MR) in Europeans suggested causal role increased BMI PCOS, whether same is Asians has yet to be investigated. We used MR infer effects using genetic data from East Asian populations. Methods Findings performed 2-sample bidirectional analysis summary statistics genome-wide association (GWAS) (with up 173 430...
Early sensory experiences interact with genes to shape precise neural circuits during development. This process is vital for proper brain function in adulthood. Neurological dysfunctions caused by environmental alterations and/or genetic mutation may share the same molecular or cellular mechanisms. Here, we show that early life bilateral whisker trimming (BWT) subsequently affects social discrimination adult male mice. Enhanced activation of hippocampal dorsal CA3 (dCA3) BWT mice was...
Objectives Medroxyprogesterone acetate (MPA), a steroid progesterone, is widely used to treat endometriosis, menstrual disorders, and uterine bleeding in clinical practice. However, the safety profile of MPA requires comprehensive evaluation.
Though commonly used, metal electrodes are incompatible with brain tissues, often leading to injury and failure achieve long-term implantation. Here we report a subdural neural interface of hydrogel functioning as an ionic conductor, elastomer dielectric. We demonstrate that it incurs far less glial reaction cerebrovascular destruction than electrode. Using cat model, the electrode was able record electrical signals comparably in quality The hydrogel-elastomer also readily facilitated...
Abstract Background Reversible splenial lesion syndrome (RESLES) is known to cause severe psychiatric symptoms but also a very rare clinical disease in which the specific aetiology unknown. According current reports, there are major causes of disease, including viral or bacterial infection, epilepsy, anti-epileptic drug withdrawal, high-altitude cerebral oedema, and metabolic disorders such as hypoglycaemia hypernatraemia. In this article, we report patient with thrombotic thrombocytopenic...
In addition to cortical areas, the thalamus also displays plasticity during a critical period in early life. Since most sensory information is transmitted cortex via thalamus, it will be of significant interest understand precise time window and underlying mechanisms this thalamus. By using vitro whole-cell patch recording acute brain slices, we found that VPm relay synapses were only sensitive whisker deprivation from postnatal day 11 (P11) P14. Whisker initiated within P11 P14...
Association of single-nucleotide polymorphisms (SNPs) the ghrelin gene with polycystic ovary syndrome (PCOS)is unclear. However, their correlation PCOS-related obesity has been observed. The objective this study was to evaluate effects SNPs on in Chinese women. full-length sequence determined explore relationship sequenced, including all exons, introns and exon–intron boundaries 230 Han women PCOS 162 normal Significant genotypic allelic differences were observed between obese group control...
Abstract Background Emerging evidence has implied that the GABRG2 gene play a role in mechanism of febrile seizure (FS), however, relationship between rs211037 polymorphism and risk FS remains controversial. This meta-analysis was conducted to investigate with susceptibility FS. Methods MEDLINE, Embase, Cochrane Library CNKI databases were searched (until April 6, 2019) for eligible studies on We calculated odds ratios (ORs) by fixed or random model STATA 15.0 software. Subgroup analyses...
Myocardial infarction (MI) is one of the most common cardiovascular diseases, inducing severe myocardial injury and leading to high mortality. Bromodomain-containing protein 7 (BRD7), a member bromodomain-containing family, involved in multiple cellular processes, such as cell cycle, transcriptional regulation, chromatin remodeling, but functions BRD7 regulating MI-associated are still obscure. In this work, we investigated effect on MI-induced vitro vivo.The MI model was established by...
Feeding behavior is imperative for the survival and reproduction of animals. Depending on motivation, feeding induced by metabolic need or hedonic reason, which associated with energy demand pleasurable food intake respectively. Although substantial differences exist, neural circuits are largely intertwined. Here, we review distinctions overlaps between to provide insights into central regulation feeding.
Abstract Background We performed this meta-analysis to investigate the association between GABRG2 rs211037polymorphism and risk for idiopathic generalized epilepsies (IGEs). Methods Medline, Embase, Cochrane Library Chinese National Knowledge Infrastructure (CNKI) databases were searched eligible studies (until May 5, 2020) on rs211037 polymorphism IGE. The odds ratios calculated using a fixed or random model in STATA 15.0 software. Subgroup analyses ethnicity, age, source of controls, type...
Background: HbA1c levels are elevated in PCOS patients, but little is known about the causal relationship. We aimed to evaluate whether glycated hemoglobin A1c (HbA1c) causally associated with polycystic ovary syndrome (PCOS) and driven by glycemic and/or nonglycemic factors.Methods: In mendelian randomization study, genetic data from several East Asian cohorts (4,386 cases 8,017 controls for PCOS; 42,790 participants BioBank Japan Project 33,741 ancestry of Meta-Analyses Glucose...
Abstract Background : Pulmonary fibrosis (PF) is a chronic progressive disease whose pathogenesis thought to be associated with activation of the immune system and consequent metabolic changes. Recent studies suggested that gut microbes are closely related host's response changes in fibrotic hosts. However, dynamic microbiome interaction profiles host metabolism during development pulmonary remain inconclusive. Results We collected serum fecal samples from bleomycin-induced mice at 0, 7, 14,...