A5024219987- Nanoplatforms for cancer theranostics
- Luminescence and Fluorescent Materials
- Photoacoustic and Ultrasonic Imaging
- Millimeter-Wave Propagation and Modeling
- Advanced Fluorescence Microscopy Techniques
- Optical Wireless Communication Technologies
- Nonlinear Optical Materials Studies
- Telecommunications and Broadcasting Technologies
- Optical Imaging and Spectroscopy Techniques
- Molecular Sensors and Ion Detection
- Neural dynamics and brain function
- Porphyrin and Phthalocyanine Chemistry
- Photoreceptor and optogenetics research
- Neuroscience and Neural Engineering
- Acute Ischemic Stroke Management
- Indoor and Outdoor Localization Technologies
- Advanced Photonic Communication Systems
- Photodynamic Therapy Research Studies
- Crystallography and Radiation Phenomena
- Topological Materials and Phenomena
- Advanced Image and Video Retrieval Techniques
- Advanced MIMO Systems Optimization
- Gold and Silver Nanoparticles Synthesis and Applications
- Advanced Wireless Communication Technologies
- X-ray Diffraction in Crystallography
University of Chinese Academy of Sciences
2024
Zhejiang University
2015-2024
Second Affiliated Hospital of Zhejiang University
2021-2024
State Key Laboratory of Modern Optical Instruments
2014-2023
Dahua Technology (China)
2018-2023
Viavi Solutions (United Kingdom)
2023
Zhejiang Lab
2022
University of Leicester
2019-2022
Optica
2017-2021
Tsinghua University
2020-2021
Fluorescence imaging in the spectral region beyond conventional near-infrared biological window (700-900 nm) can theoretically afford high resolution and deep tissue penetration. Although some efforts have been devoted to developing a short-wave infrared (SWIR; 900-1700 modality past decade, long-wavelength biomedical is still suboptimal owing unsatisfactory materials properties of SWIR fluorophores. Taking advantage organic dots based on an aggregation-induced emission luminogen (AIEgen),...
Second near-infrared (NIR-II, 1000-1700 nm) fluorescence bioimaging has attracted tremendous scientific interest and already been used in many biomedical studies. However, reports on organic NIR-II fluorescent probes for vivo photoinduced imaging simultaneous therapy, as well the long-term tracing of specific biological objects, are still very rare. Herein we designed a single-molecular NIR-II-emissive theranostic system by encapsulating kind aggregation-induced emission luminogen (AIEgen,...
Currently, a serious problem obstructing the large-scale clinical applications of fluorescence technique is shallow penetration depth. Two-photon microscopic imaging with excitation in longer-wavelength near-infrared (NIR) region (>1100 nm) and emission NIR-I (650–950 good choice to realize deep-tissue high-resolution imaging. Here, we report ultradeep two-photon bioimaging 1300 nm NIR-II (peak ∼810 based on NIR aggregation-induced luminogen (AIEgen). The crab-shaped AIEgen possesses planar...
The traditional design strategies for highly bright solid-state luminescent materials rely on weakening the intermolecular π-π interactions, which may limit diversity when developing new materials. Herein, we propose a strategy of tuning molecular packing mode by regioisomerization to regulate fluorescence. TBP-e-TPA with rotor in end position planar core adopts long-range cofacial mode, solid state is almost non-emissive. By shifting rotors bay position, resultant TBP-b-TPA possesses...
The development of fluorogens with deep-red emission is one the hottest topics investigation in field bio/chemosensors and bioimaging. Herein, tunable fluorescence perylene diimide (PDI) derivatives was achieved by incorporation varied isolation groups linked on PDI core. With enlarged sizes groups, conversion from aggregation caused quenching to aggregation-induced obtained their variations solutions nanoparticles, as result efficient inhibition π-π stacking larger groups. Accordingly,...
Organic fluorescent dyes with high quantum yield are widely applied in bioimaging and biosensing. However, most of them suffer from a severe effect called aggregation-caused quenching (ACQ), which means that their fluorescence is quenched at molecular concentrations or the aggregation state. Aggregation-induced emission (AIE) diametrically opposite phenomenon to ACQ, luminogens this feature can effectively solve problem. Graphene oxide has been utilized as quencher for many dyes, based on...
2,3-bis(4-(phenyl(4-(1,2,2-triphenylvinyl)phenyl)amino)phenyl)fumaronitrile (TTF) shows unique aggregation-induced emission (AIE) characteristics. Under the excitation of a 1560 nm femtosecond laser, simultaneous three-photon-excited luminescence (3PL) and third-harmonic-generation signals can be observed from its nanoaggregate solid state. TTF is further encapsulated with DSPE-mPEG (a type amphiphilic polymer) to form AIE-active nanoparticles. 3PL brain imaging mice achieved based on
Three-photon fluorescence microscopic (3PFM) bioimaging is a promising imaging technique for visualizing the brain in its native environment thanks to advantages of high spatial resolution and large depth. However, developing fluorophores with strong three-photon absorption (3PA) bright emission that meets requirements efficient still challenging. Herein, four aggregation-induced features are facilely synthesized, their powders exhibit quantum yields up 56.4%. The intramolecular engineering...
Many features of 5G are definitely important to the broadcasting service, including diverse content services such as follow-me TV, video-on-demand, but also gaming, Virtual reality (VR) and Augmented (AR) many others. Meanwhile, those depend more on user's position accuracy, especially in indoor environment. With increase data traffic indoors, obtain a highly accurate is becoming challenge because impact radio interference. In order support high-quality high-accuracy positioning,...
Due to the great demand of throughput and reliability for multimedia applications in Fifth Generation (5G) networks, many broadcasting systems adopt Millimeter Wave (mmWave) technology address lack spectrum resources. As one 5G-PPP projects, Internet Radio Light (IoRL) project adopts 40GHz mmWave band support a high-speed stable Ultra-High-Definition (UHD) television service indoor environment. Because high frequency property, bands usually suffers from path loss penetration loss. Thus,...
Three-photon luminescence (3PL) imaging with near-infrared (NIR) excitation is quite promising for its deep penetration, high resolution, and good signal-to-noise ratio (SNR). In this report, a type of red emissive fluorophore TPEPT aggregation-induced emission (AIE) properties was synthesized, it found to possess large three-photon absorption (3PA) cross-section 6.33 × 10-78 cm6 s2 under 1550 nm femtosecond laser excitation. then encapsulated mPEG5000-DSPE form AIE nanoparticles, the...
Abstract The traditional design strategies for highly bright solid‐state luminescent materials rely on weakening the intermolecular π–π interactions, which may limit diversity when developing new materials. Herein, we propose a strategy of tuning molecular packing mode by regioisomerization to regulate fluorescence. TBP‐ e ‐TPA with rotor in end position planar core adopts long‐range cofacial mode, solid state is almost non‐emissive. By shifting rotors bay position, resultant b possesses...
The Internet of Radio-Light (IoRL) is a cutting-edge system paradigm to enable seamless 5G service provision in indoor environments, such as homes, hospitals, and museums. draws on innovative architectural structure that sits the synergy between Radio Access Network (RAN) technologies millimeter Wave communications (mmWave) Visible Light Communications (VLC) for improving network throughput, latency, coverage compared existing efforts. aim this paper introduce IoRL architecture present key...
Here we present organic AIE nanoparticles that feature high absorption cross-section under NIR-IIa three-photon excitation, which enables ultra-deep fluorescence imaging in the<italic>in vivo</italic>mouse brain.
Though commonly used, metal electrodes are incompatible with brain tissues, often leading to injury and failure achieve long-term implantation. Here we report a subdural neural interface of hydrogel functioning as an ionic conductor, elastomer dielectric. We demonstrate that it incurs far less glial reaction cerebrovascular destruction than electrode. Using cat model, the electrode was able record electrical signals comparably in quality The hydrogel-elastomer also readily facilitated...
Abstract The spinal cord (SC) is crucial for a myriad of somatosensory, autonomic signal processing, and transductions. Understanding the SC vascular structure function thus plays an integral part in neuroscience clinical research. However, dense layers myelinated ascending axons on dorsal side inconveniently grant tissue with high optical scattering property, which significantly hinders imaging depth vasculature vivo. Commonly used antiscattering techniques such as multiphoton fluorescence...
Multiphoton microscopy has been a powerful tool in brain research, three-photon fluorescence is increasingly becoming an emerging technique for neurological research of the cortex depth. Nonhuman primates play important roles study science because their neural and vascular similarity to humans. However, there are few results on nonhuman due lack optimized imaging systems excellent fluorescent probes. Here we introduced bright aggregation-induced emission (AIE) probe with efficiency as well...
SignificancePulsed infrared neural stimulation (INS, 1875 nm) is an emerging neurostimulation technology that delivers focal pulsed heat to activate functionally specific mesoscale networks and holds promise for clinical application. However, little known about its effect on excitatory inhibitory cell types in cerebral cortex.AimEstimates of summed population neuronal response time courses provide a potential basis hemodynamic signals described other studies.ApproachUsing two-photon calcium...
In this paper, we present a new one stage detector for object detection. order to meet the requirements of real-time detection, use MobileNetV2-FPN as backbone feature extraction. The lightweight depthwise separable convolutions can improve speed detection and make model smaller. accuracy our small model, add Stem Block into SEnet in front two task-specific subnets. stem block reduce information loss from raw input images. enhance useful features network suppress that are little two-specific...
Abstract The significance of performing large‐depth dynamic microscopic imaging in vivo for life science research cannot be overstated. However, the optical throughput microscope limits available information per unit time, i.e., it is difficult to obtain both high spatial and temporal resolution at once. Here, a method proposed construct kind intravital microscopy with throughput, by making near‐infrared‐II (NIR‐II, 900–1880 nm) wide‐field fluorescence learn from two‐photon based on...