A5072449236- Neural dynamics and brain function
- Visual perception and processing mechanisms
- Photoreceptor and optogenetics research
- Functional Brain Connectivity Studies
- Neuroscience and Neural Engineering
- Retinal Development and Disorders
- Advanced MRI Techniques and Applications
- Neurobiology and Insect Physiology Research
- Optical Imaging and Spectroscopy Techniques
- Color Science and Applications
- EEG and Brain-Computer Interfaces
- Tactile and Sensory Interactions
- Photoacoustic and Ultrasonic Imaging
- Advanced Neuroimaging Techniques and Applications
- Advanced Fluorescence Microscopy Techniques
- Neuroscience and Neuropharmacology Research
- Nanoplatforms for cancer theranostics
- Glaucoma and retinal disorders
- Multisensory perception and integration
- Genetic Neurodegenerative Diseases
- Color perception and design
- Neurological disorders and treatments
- Advanced NMR Techniques and Applications
- Face Recognition and Perception
- Transcranial Magnetic Stimulation Studies
Zhejiang University
2016-2025
Second Affiliated Hospital of Zhejiang University
2019-2024
Zhejiang Lab
2022-2024
Zero to Three
2024
Brain (Germany)
2022-2024
Hangzhou Xixi hospital
2023
Oregon National Primate Research Center
2007-2022
Oregon Health & Science University
2016-2022
Zhejiang Institute of Science and Technology Information
2019-2020
Optica
2020
Retinal cells have been induced to project into the medial geniculate nucleus, principal auditory thalamic in newborn ferrets by reduction of targets retinal axons one hemisphere and creation alternative terminal space for these fibers thalamus. Many nucleus are then visually driven, large receptive fields, receive input from ganglion with small somata slow conduction velocities. Visual long latencies contralateral fields can also be recorded primary cortex. Some visual cortex direction...
The second visual cortical area (V2) of the primate is composed repeating thin, pale, and thick cytochrome oxidase stripes containing primarily color-selective, broad-band oriented, disparity-selective cells, respectively. We have now examined topography in V2 with respect to these functional subdivisions. Our data suggest that there are multiple, interleaved maps V2, one for each color, orientation, disparity domains. same region space re-represented by stripe within a cycle, resulting...
Maps of sensory surfaces are a fundamental feature cortical areas the brain. The relative roles afferents and targets in forming neocortical maps higher mammals can be examined ferrets which retinal inputs directed into auditory pathway. In these animals, primary cortex contains systematic representation retina (and visual space) rather than cochlea sound frequency). A two-dimensional epithelium, retina, that normally represents one-dimensional cochlea, suggests same area support different...
It is known that neurons in area V2 (the second visual area) can signal the orientation of illusory contours primate. Whether V1 (primary cortex) contour more controversial. While some electrophysiology studies have ruled out signaling V1, other reports suggest shows illusory-specific response. Here, using optical imaging and single unit electrophysiology, we report primate does show an orientation-specific response to ‘abutting line grating’ contour. However, this not conventional sense....
Areas V1 and V2 of Macaque monkey visual cortex are characterized by unique cytochrome-oxidase (CO)-staining patterns. Initial electrophysiological studies associated CO blobs in with processing surface properties such as color brightness the interblobs contour information processing. However, many subsequent showed controversial results, some supporting this proposal others failing to find significant functional differences between interblobs. In study, we have used optical imaging map...
How does cortex that normally processes inputs from one sensory modality respond when provided with input a different modality? We have addressed such question an experimental preparation in which retinal is routed to the auditory pathway ferrets. Following neonatal surgical manipulations, specific population of ganglion cells induced innervate thalamus and provides visual (Sur et al., 1988). now examined detail response properties single primary (A1) these rewired animals compared responses...
Optogenetics combines optics and genetics to control neuronal activity with cell-type specificity millisecond temporal precision. Its use in model organisms such as rodents, Drosophila, Caenorhabditis elegans is now well-established. However, application of this technology nonhuman primates (NHPs) has been slow develop. One key challenge the delivery viruses light brain through thick dura mater NHPs, which can only be penetrated large-diameter devices that damage brain. The opacity NHP...
Normalization has been proposed as a canonical computation that accounts for variety of nonlinear neuronal response properties associated with sensory processing and higher cognitive functions. A key premise normalization is the excitability neuron inversely proportional to overall activity level network. We tested this by optogenetically activating excitatory neurons in alert macaque primary visual cortex measuring changes function stimulation intensity, or without variable-contrast...
Vasculature architecture of the brain can provide revealing information about mental and neurological function disease.Fluorescence imaging in second near-infrared (NIR-II) regime with less light scattering is a more promising method for detecting cortical vessels than traditional visible NIR-I modes.Methods: Clinically approved dye indocyanine green (ICG) was used NIR-II fluorescence imaging.Here, first time, we developed two microscopy systems vasculature macaque monkeys.The wide-field...
In human and nonhuman primate brains, columnar (mesoscale) organization has been demonstrated to underlie both lower higher order aspects of visual information processing. Previous studies have focused on identifying functional preferences mesoscale domains in specific areas; but there little understanding how may cooperatively respond single stimuli across dorsal ventral pathways. Here, we developed ultrahigh-field 7 T fMRI methods enable simultaneous mapping, individual macaque monkeys,...
In the tactile funneling illusion, simultaneous presentation of brief stimuli at multiple points on skin produces a single focal sensation center stimulus pattern even when no physical occurs that site. Consistent with percept, we show optical imaging in area 3b primary somatosensory cortex (SI) stimulation two fingertips cortical activation between fingertip regions. Thus, contrast to traditional views body map, topographic representation SI reflects perceived rather than location...