A5024300858- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Visual perception and processing mechanisms
- Retinal Development and Disorders
- Photoreceptor and optogenetics research
- Genetics and Neurodevelopmental Disorders
- Neuroscience and Neural Engineering
- Neurobiology and Insect Physiology Research
- Memory and Neural Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Receptor Mechanisms and Signaling
- Advanced Fluorescence Microscopy Techniques
- EEG and Brain-Computer Interfaces
- Autism Spectrum Disorder Research
- Tactile and Sensory Interactions
- Neurogenesis and neuroplasticity mechanisms
- Axon Guidance and Neuronal Signaling
- Glaucoma and retinal disorders
- Functional Brain Connectivity Studies
- Advanced Memory and Neural Computing
- MicroRNA in disease regulation
- Cell Image Analysis Techniques
- CRISPR and Genetic Engineering
- Epigenetics and DNA Methylation
- Motor Control and Adaptation
Massachusetts Institute of Technology
2016-2025
Institute of Cognitive and Brain Sciences
2011-2025
Simons Foundation
2014-2022
Vassar College
2013-2022
Institute for Advanced Learning and Research
2021
Trinity College Dublin
2012
KU Leuven
2012
Vanderbilt University
1978-2011
Fudan University
2011
University of Rochester
2011
Neuroplasticity can be defined as the ability of nervous system to respond intrinsic or extrinsic stimuli by reorganizing its structure, function and connections. Major advances in understanding neuroplasticity have date yielded few established interventions. To advance translation research towards clinical applications, National Institutes Health Blueprint for Neuroscience Research sponsored a workshop 2009. Basic researchers disciplines from central injury/stroke, mental/addictive...
It is well known that visual cortical neurons respond vigorously to a limited range of stimulus orientations, while their primary afferent inputs, in the lateral geniculate nucleus (LGN), all orientations. Mechanisms based on intracortical inhibition and/or converging thalamocortical afferents have previously been suggested underlie generation orientation selectivity; however, these models conflict with experimental data. Here, 1:4 scale model 1700 microns by 200 microms region layer IV cat...
Microelectrode mapping experiments indicate that the classical primary somatosensory cortex of monkeys consists as many four separate body representations rather than just one. Two complete surface occupy cortical fields 3b and 1. In addition, area 2 contains an orderly representation predominantly "deep" tissues. Area 3a may constitute a fourth representation.
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Astrocytes have long been thought to act as a support network for neurons, with little role in information representation or processing. We used two-photon imaging of calcium signals the ferret visual cortex vivo discover that astrocytes, like respond stimuli, distinct spatial receptive fields and sharp tuning stimulus features including orientation frequency. The stimulus-feature preferences astrocytes were exquisitely mapped across cortical surface, close register neuronal maps. spatially...
Rett Syndrome (RTT) is a severe form of X-linked mental retardation caused by mutations in the gene coding for methyl CpG-binding protein 2 (MECP2). Mice deficient MeCP2 have range physiological and neurological abnormalities that mimic human syndrome. Here we show systemic treatment mutant mice with an active peptide fragment Insulin-like Growth Factor 1 (IGF-1) extends life span mice, improves locomotor function, ameliorates breathing patterns, reduces irregularity heart rate. In addition,...
Retinal cells have been induced to project into the medial geniculate nucleus, principal auditory thalamic in newborn ferrets by reduction of targets retinal axons one hemisphere and creation alternative terminal space for these fibers thalamus. Many nucleus are then visually driven, large receptive fields, receive input from ganglion with small somata slow conduction velocities. Visual long latencies contralateral fields can also be recorded primary cortex. Some visual cortex direction...
Abstract Microelectrode multiunit mapping studies of parietal cortex in owl monkeys indicate that the classical “primary” somatosensory region (or “SI”) including separate architectonic fields 3a, 3b, 1, and 2 contains as many four representations body rather than one. An analysis receptive field locations for extensive arrays closely placed recording sites which were later related to cortical architecture led following conclusions: (1) There are two large systematic surface within “SI”....
Abstract The somatotopic organization of the postcentral parietal cortex Old World monkey, Macaca fascicularis , was determined with multi‐unit microelectrode recordings. results lead to following conclusions: (1) There are at least two complete and systematic representations contralateral body surface in gyrus. One representation is contained within Area 3b, other 1. (2) While there important differences representations, they basically mirror‐images each other. (3) Each maintains...