A5101553743- Traumatic Brain Injury Research
- Neural dynamics and brain function
- Traumatic Brain Injury and Neurovascular Disturbances
- Nonlinear Waves and Solitons
- Advanced Neuroimaging Techniques and Applications
- EEG and Brain-Computer Interfaces
- Neural and Behavioral Psychology Studies
- Functional Brain Connectivity Studies
- Nonlinear Photonic Systems
- Hydrology and Watershed Management Studies
- DNA Repair Mechanisms
- Neuroendocrine regulation and behavior
- Neuroscience and Neural Engineering
- Neuroinflammation and Neurodegeneration Mechanisms
- DNA and Nucleic Acid Chemistry
- Single-cell and spatial transcriptomics
- Photoreceptor and optogenetics research
- Cardiac Arrest and Resuscitation
- Neuroscience and Neuropharmacology Research
- Molecular spectroscopy and chirality
- Primate Behavior and Ecology
- Memory and Neural Mechanisms
- Cancer, Stress, Anesthesia, and Immune Response
- Receptor Mechanisms and Signaling
- Sports injuries and prevention
University of Pennsylvania
2017-2025
Université Laval
2024
California University of Pennsylvania
2022
Montreal Neurological Institute and Hospital
2014-2022
Philadelphia University
2022
McGill University
2013-2022
Institut Universitaire de Gériatrie de Montréal
2014
Université de Montréal
1998-2013
Centre de recherche cerveau et cognition
2011-2012
Université du Québec à Trois-Rivières
2008
Recent studies have shown that the detrimental effects of sports concussions on cognitive and motor function may persist up to a few years post-injury. The present study sought investigate having sustained concussion more than 30 prior testing functions. Nineteen healthy former athletes, in late adulthood (mean age = 60.79; SD 5.16), who their last sport-related early 26.05; 9.21) were compared with 21 athletes no history 58.89; 9.07). Neuropsychological tests sensitive age-related changes...
Despite negative neuroimaging findings in concussed athletes, studies indicate that the acceleration and deceleration of brain after concussive impacts result metabolic electrophysiological alterations may be attributable to changes white matter resulting from biomechanical strain. In present study we investigated effects sports concussion on using three different diffusion tensor imaging (DTI) measures: fractional anisotropy (FA), mean diffusivity (MD), axial (AD). We compared a group 10...
Sports concussion is a major problem that affects thousands of people in North America every year. Despite negative neuroimaging findings, many athletes display neurophysiological alterations and post-concussion symptoms such as headaches sensitivity to light noise. It suspected neurometabolic changes may underlie these changes. In this study we investigated the effects sports on brain metabolism using (1)H-MR spectroscopy by comparing group 12 non-concussed with concussed same age (mean...
Recent epidemiological and experimental studies suggest a link between cognitive decline in late adulthood sports concussions sustained early adulthood. In order to provide the first vivo neuroanatomical evidence of this relation, present study probes neuroimaging profile former athletes with relation cognition. Former who their last concussion >3 decades prior testing were compared those no history traumatic brain injury. Participants underwent quantitative (optimized voxel-based...
Context: The known detrimental effects of sport concussions on motor system function include balance problems, slowed execution, and abnormal cortex excitability. Objective: To assess whether these concussion-related alterations are still evident in collegiate football players who sustained but returned to competition more than 9 months before testing. Design: Case-control study. Setting: University laboratory. Patients or Other Participants: A group 21 active, university-level had...
Despite negative neuroimaging findings many athletes display neurophysiological alterations and post-concussion symptoms that may be attributable to neurometabolic alterations. The present study investigated the effects of sports concussion on brain metabolism using 1H-MR Spectroscopy by comparing a group 10 non-concussed with concussed same age (mean: 22.5 years) education 16 within both acute chronic post-injury phases. All were scanned 1-6 days again 6-months later in 3T Siemens MRI....
Persistent motor/cognitive alterations and increased prevalence of Alzheimer's disease are known consequences recurrent sports concussions, the most prevalent cause mild traumatic brain injury (TBI) among youth. Animal models TBI demonstrated that impaired learning was related to persistent synaptic plasticity suppression in form long-term potentiation (LTP) depression (LTD). In humans, single repeated concussive injuries lead lifelong cumulative enhancements gamma-aminobutyric acid...
Sports-related concussions have been shown to lead persistent subclinical anomalies of the motor and cognitive systems in young asymptomatic athletes. In advancing age, these latent alterations correlate with detectable function decline. Until now, interacting effects normal ageing process on white matter tract integrity remain unknown. Here we used a tract-based spatial statistical method uncover potential tissue damage 15 retired athletes history concussions, free comorbid medical...
The activity of neurons in the primate lateral prefrontal cortex (LPFC) is strongly modulated by visual attention. Such a modulation has mostly been documented averaging independently recorded over repeated experimental trials. However, realistic settings, ensembles simultaneously active LPFC must generate attentional signals on single-trial basis, despite individual and correlated variability neuronal responses. Whether, under these circumstances, can reliably unclear. Here, we show that...
Cataloging the diverse cellular architecture of primate brain is crucial for understanding cognition, behavior, and disease in humans. Here, we generated a brain-wide single-cell multimodal molecular atlas rhesus macaque brain. Together, profiled 2.58 M transcriptomes 1.59 epigenomes from single nuclei sampled 30 regions across adult Cell composition differed extensively brain, revealing signatures region-specific functions. We also identified 1.19 candidate regulatory elements, many...
Event-related potentials (ERPs) have been useful to detect subtle, pervasive alterations of cognition-related waveforms in athletes with multiple concussions. This study used the sustained posterior contralateral negativity (SPCN) waveform component recorded while participants performed a visual short-term memory task investigate how working (WM) storage capacity was affected among who differed according their history sports Fifty-five university-level football players were assigned three...
Understanding the neurobiological mechanisms underlying HIV-associated neurocognitive decline in people living with HIV is frequently complicated by an inability to analyze changes across course of infection and frequent presence comorbid psychiatric substance use disorders. Preclinical non-human primate simian immunodeficiency virus (SIV) models help address these shortcomings. However, SIV studies target protracted endpoints, limiting our understanding neuromolecular alterations during...
Abstract Background Retired athletes with a history of sports concussions experience cognitive and motor declines aging, the risk severe neurodegenerative conditions is magnified in this population. The present study investigated effects aging on system metabolism function former university-level who sustained their last concussion several decades prior to testing. Methods To test hypothesis that age remote induce functional as well metabolic alterations system, we used proton magnetic...
Local field potentials (LFPs) are fluctuations of extracellular voltage that may reflect the physiological phenomena occurring within a volume neural tissue. It is known allocation spatial attention modulates amplitude LFPs in visual areas primates. An issue remains poorly investigated whether and how executive brain areas, such as lateral prefrontal cortex (LPFC), thought to be involved origins attention. We addressed this by recording from multielectrode arrays implanted LPFC two macaques....
With concurrent global epidemics of chronic pain and opioid use disorders, there is a critical need to identify, target manipulate specific cell populations expressing the mu-opioid receptor (MOR). However, available tools transgenic models for gaining long-term genetic access MOR+ neural types circuits involved in modulating pain, analgesia addiction across species are limited. To address this, we developed catalog MOR promoter (MORp) based constructs packaged into adeno-associated viral...
A method is presented for finding the Lie point symmetry transformations acting simultaneously on difference equations and lattices, while leaving solution set of corresponding scheme invariant. The applied to several examples. found groups are used obtain particular solutions differential-difference equations.
A method is presented for calculating the Lie point symmetries of a scalar difference equation on two-dimensional lattice. The symmetry transformations act equations and They take solutions into can be used to perform reduction. generalizes one in recent publication case ordinary equations. In turn, it easily generalized systems involving an arbitrary number dependent independent variables.