A5017316328- Neural dynamics and brain function
- Neuroscience and Music Perception
- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Neuroscience and Neural Engineering
- stochastic dynamics and bifurcation
- Photoreceptor and optogenetics research
- Neuroscience and Neuropharmacology Research
- Hearing Loss and Rehabilitation
- Neural Networks and Applications
- Urban Green Space and Health
- Visual perception and processing mechanisms
- Autism Spectrum Disorder Research
- Fractal and DNA sequence analysis
- Neural and Behavioral Psychology Studies
- Color perception and design
- Congenital heart defects research
- Optical Polarization and Ellipsometry
- Optical Imaging and Spectroscopy Techniques
- Physical Education and Training Studies
- Complementary and Alternative Medicine Studies
- Neuroscience of respiration and sleep
- activated carbon and charcoal
- RNA regulation and disease
- Gaze Tracking and Assistive Technology
Tokyo Institute of Technology
2007-2025
RIKEN Center for Brain Science
2014-2024
National Center of Neurology and Psychiatry
2020-2023
Kanagawa University
2018
Chiba University
2014
Background . Despite increasing attention toward forest therapy as an alternative medicine, very little evidence continues to be available on its therapeutic effects. Therefore, this study was focused elucidating the health benefits of walking cardiovascular reactivity. Methods Within‐group comparisons were used examine responses in and urban environments. Forty‐eight young adult males participated two‐day field research. Changes heart rate variability, rate, blood pressure measured...
In recent years, the physiological relaxing effect brought by nature is becoming clear; however, many workers find it difficult to be exposed in their working environment. Exposure fresh flowers represents an opportunity incorporate into lives. this study, we examined effects of exposure roses on and psychological variables (heart rate variability, pulse rate, subjective responses) office workers. The experimental site was Mizuho Information & Research Institute, Inc., Tokyo metropolitan...
Our brains constantly generate predictions of sensory input that are compared with actual inputs, propagate the prediction-errors through a hierarchy brain regions, and subsequently update internal world. However, essential feature predictive coding, notion hierarchical depth its neural mechanisms, remains largely unexplored. Here, we investigated auditory processing by combining functional magnetic resonance imaging (fMRI) high-density whole-brain electrocorticography (ECoG) in marmoset...
Abstract A relevant question concerning inter-areal communication in the cortex is whether these interactions are synergistic. Synergy refers to complementary effect of multiple brain signals conveying more information than sum each isolated signal. Redundancy, on other hand, common shared between signals. Here, we dissociated cortical encoding (synergy) from those sharing (redundancy) during prediction error (PE) processing. We analyzed auditory and frontal electrocorticography (ECoG) five...
At the forefront of bridging computational brain modeling with personalized medicine, this study introduces a novel, real-time, electrocorticogram (ECoG) simulator, based on digital twin concept. Utilizing advanced data assimilation techniques, specifically Variational Bayesian Recurrent Neural Network model hierarchical latent units, simulator dynamically predicts ECoG signals reflecting real-time states. By assimilating broad from macaque monkeys across awake and anesthetized conditions,...
Abstract Mismatch negativity (MMN) is a component of event-related potentials (ERPs) evoked by violations regularity in sensory stimulus-series humans. Recently, the MMN has received attention as clinical and translatable biomarker psychiatric disorders such schizophrenia for development animal models these disorders. In this study, we investigated generation common marmosets, which are an important non-human primate model with genetic manipulability. We recorded electrocorticograms (ECoGs)...
Numerous studies have shown that the visual system consists of functionally distinct ventral and dorsal streams; however, its exact spatial-temporal dynamics during natural behavior remain to be investigated. Here, we report cerebral neural active exploration recorded by an electrocorticographic array covering entire lateral surface marmoset cortex. We found stream was activated before primary cortex with saccades followed alteration suppression activation signals along stream. Similarly,...
Although cortical feedback signals are essential for modulating feedforward processing, no error signal across hierarchical areas has been reported. Here, we observed such a in the auditory cortex of awake common marmoset during an oddball paradigm to induce duration mismatch negativity. Prediction errors deviant tone presentation were generated as offset calcium responses layer 2/3 neurons rostral parabelt (RPB) higher-order cortex, while non-deviant tones strongly suppressed. Within...
Optogenetics has potential applications in the study of epilepsy and neuroprostheses, for studies on neural circuit dynamics. However, to achieve translation clinical usage, optogenetic interfaces that are capable chronic stimulation monitoring with minimal brain trauma required. We aimed develop a chronically implantable device photostimulation non-human primates. used micro-light-emitting diode (LED) array flexible polyimide film. The was combined whole-cortex electrocorticographic (ECoG)...
Detection of statistical irregularities, measured as a prediction error response, is fundamental to the perceptual monitoring environment. We studied whether response associated with neural oscillations or asynchronous broadband activity. Electrocorticography was conducted in three male monkeys, who passively listened auditory roving oddball stimuli. Local field potentials (LFPs) recorded over cortex underwent spectral principal component analysis, which decoupled and rhythmic components LFP...
Abstract Sound frequency and duration are essential auditory components. The brain perceives deviations from the preceding sound context as prediction errors, allowing efficient reactions to environment. Additionally, error response change is reduced in initial stages of psychotic disorders. To compare spatiotemporal profiles responses we conducted a human electrocorticography study with special attention high gamma power 13 participants who completed both oddball tasks. Remarkable...
Abstract In autism spectrum disorder (ASD), atypical sensory experiences are often associated with irregularities in predictive coding, which proposes that the brain creates hierarchical models via a bidirectional process of predictions and prediction errors. However, it remains unclear how these manifest across different functional hierarchies brain. To address this, we study marmoset model ASD induced by valproic acid (VPA) treatment. We record high-density electrocorticography (ECoG)...
Abstract An important question concerning inter-areal communication in the cortex is whether these interactions are synergistic, i.e. brain signals can either share common information (redundancy) or they encode complementary that only available when both considered together (synergy). Here, we dissociated cortical sharing from those encoding during prediction error processing. To this end, computed co-information, an information-theoretical measure distinguishes redundant synergistic among...
Electrophysiological Source Imaging (ESI) is hampered by lack of "gold standards" for model validation. Concurrent electroencephalography (EEG) and electrocorticography (ECoG) experiments (EECoG) are useful this purpose, especially primate models due to their flexibility translational value human research. Unfortunately, there only one EECoG in the public domain that we know of: Multidimensional Recording (MDR) based on a single monkey ( www.neurotycho.org ). The mining type data hindered...
Auditory mismatch negativity (MMN) is an electrophysiological response to a deviation from regularity. This considered pivotal understanding auditory processing, particularly in the pre-attentive phase. However, previous findings suggest that MMN product of N1 adaptation/enhancement, which reflects lower-order processing. The separability these two components remains unclear and important issue field neuroscience. aim present study was spatiotemporally differentiate adaptation using human...
Electrocorticography (ECoG) allows the monitoring of electrical field potentials from cerebral cortex with high spatiotemporal resolution. Recent development thin, flexible ECoG electrodes has enabled conduction stable recordings large-scale cortical activity. We have developed a whole-cortical array for common marmoset. The continuously covers almost entire lateral surface hemisphere, occipital pole to temporal and frontal poles, it captures neural activity in one shot. This protocol...
In addition to primary rewards such as food and water, humans continuously seek information in daily life. Whereas the neural mechanisms for processing have been clarified detail homeostatic system, those seeking remain poorly understood. Although studies psychology economics suggested several criteria with which is assessed human seeking, mechanism that assesses remains unknown. The include value of (VOI; Hubbard, 2010), Shannon information, probability gain (Baron, 1985), are defined...
Ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, exerts broad effects on consciousness and perception. Since NMDA antagonists induce cognitive impairments, ketamine has been used for translational research several psychiatric diseases, such as schizophrenia. Whereas the of functions have extensively studied, studies simple sensory information processing remain limited. In this study, we investigated cortex-wide administration auditory in nonhuman primates using whole-cortical...
ABSTRACT At the forefront of bridging computational brain modeling with personalized medicine, this study introduces a novel, real-time, electrocorticogram (ECoG) simulator based on digital twin concept. Utilizing advanced data assimilation techniques, specifically Variational Bayesian Recurrent Neural Network model hierarchical latent units, dynamically predicts ECoG signals reflecting real-time states. By assimilating broad from Macaque monkeys across awake and anesthetized conditions,...
Auditory sensory processing is assumed to occur in a hierarchical structure including the primary auditory cortex (A1), superior temporal gyrus, and frontal areas. These areas are postulated generate predictions for incoming stimuli, creating an internal model of surrounding environment. Previous studies on mismatch negativity have indicated involvement gyrus this processing, whereas reports been mixed regarding contribution cortex. We designed novel paradigm, "cascade roving" which...
Abstract Electrophysiological Source Imaging (ESI) methods are hampered by the lack of “gold standards” for model comparison. Concurrent electroencephalography (EEG) and electrocorticography (ECoG) recordings (namely EECoG) considered gold standard to validating EEG generative models with primate have unique advantages both flexibility translational value in human research. However severe artifacts during such invasive experiments, complexity providing sufficiently detailed biophysical...
Focusing on waste biomass made from wood-based as a raw material, in order to effectively utilize charcoal, such construction waste, sawdust, cotton linters, etc. VOC adsorbent room, thermogravimetric analysis and headspace Gas Chromatography well evolved gas were used evaluate the adsorption properties. This method can be evaluated with about 10 mg of carbonized 1 μL or less, which is an effective evaluation method. The characteristics vary depending material. properties also differed...