A5061126255- EEG and Brain-Computer Interfaces
- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Neuroscience and Neural Engineering
- Neurological disorders and treatments
- Anatomy and Medical Technology
- Surgical Simulation and Training
- Motor Control and Adaptation
- Vascular Malformations Diagnosis and Treatment
- Nonlinear Dynamics and Pattern Formation
- Neuroscience and Music Perception
- Ophthalmology and Eye Disorders
- Neural and Behavioral Psychology Studies
- Intracranial Aneurysms: Treatment and Complications
- Bone Tumor Diagnosis and Treatments
- Nitric Oxide and Endothelin Effects
- Cardiac, Anesthesia and Surgical Outcomes
- Musculoskeletal synovial abnormalities and treatments
- Muscle activation and electromyography studies
- Simulation-Based Education in Healthcare
- Radio Astronomy Observations and Technology
- Electrochemical Analysis and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Fatty Acid Research and Health
- Wireless Communication Networks Research
Mayo Clinic
2021-2025
WinnMed
2021-2025
Mayo Clinic in Arizona
2022-2024
Neurological Surgery
2023
Mayo Clinic in Florida
2023
University of Oklahoma Health Sciences Center
2023
Oregon Health & Science University
2022
Augusta University
2006
Abstract Cells in the precentral gyrus directly send signals to periphery generate movement and are principally organized as a topological map of body. We find that movement-induced electrophysiological responses from depth electrodes extend this three-dimensionally throughout gyrus. Unexpectedly, organization is interrupted by previously undescribed motor association area depths midlateral aspect central sulcus. This ‘Rolandic association’ (RMA) active during movements different body parts...
Abstract A relevant question concerning inter-areal communication in the cortex is whether these interactions are synergistic. Synergy refers to complementary effect of multiple brain signals conveying more information than sum each isolated signal. Redundancy, on other hand, common shared between signals. Here, we dissociated cortical encoding (synergy) from those sharing (redundancy) during prediction error (PE) processing. We analyzed auditory and frontal electrocorticography (ECoG) five...
Deep brain stimulation (DBS) is a targeted manipulation of circuitry to treat neurological and neuropsychiatric conditions. Optimal DBS lead placement essential for treatment efficacy. Current targeting practice based on preoperative intraoperative imaging, electrophysiology, mapping. Electrophysiological mapping using extracellular microelectrode recordings aids in identifying functional subdomains, anatomical boundaries, disease-correlated physiology. The shape single-unit action...
The cortex generates diverse neural dynamics, ranging from broadband fluctuations to narrowband oscillations in specific frequency bands. Here, we investigated whether and oscillatory dynamics play different roles the encoding transmission of synergistic redundant information. We used information-theoretical measures dissociate signals sharing common information (i.e., redundancy) complementary synergy). analyzed electrocorticography (ECoG) local field potentials (LFP) visual human non-human...
Stereoelectroencephalography (sEEG) is a method of epilepsy monitoring that uses stereotactically placed depth electrodes. Connectivity between brain regions may be assessed by delivering current pulse from sEEG electrode(s) and all other electrodes for Brain Stimulation-Evoked Potentials (BSEPs). However, the shape, magnitude, spectral content BSEPs are sensitive to analysis approaches used study them. In order understand nuance interpretation BSEP data, we carefully apply contrast modified...
Abstract An important question concerning inter-areal communication in the cortex is whether these interactions are synergistic, i.e. brain signals can either share common information (redundancy) or they encode complementary that only available when both considered together (synergy). Here, we dissociated cortical sharing from those encoding during prediction error processing. To this end, computed co-information, an information-theoretical measure distinguishes redundant synergistic among...
OBJECTIVE Stereoelectroencephalography (SEEG) has become the predominant method for intracranial seizure localization. When imaging, semiology, and scalp EEG findings are not in full agreement or definitively localizing, implanted SEEG recordings used to test candidate onset zones (SOZs). Discovered SOZs may then be targeted resection, laser ablation, neurostimulation. If an SOZ is eloquent, resection ablation both contraindicated, so identifying functional representation crucial therapeutic...
Abstract Soluble epoxide hydrolase (sEH) is upregulated in microvascular endothelium of human brain with vascular cognitive impairment (VCI). Transgenic endothelial expression sEH mice (Tie2hsEH) induces dysfunction (ED), a pathogenetic mechanism VCI. We sought to determine if upregulation sufficient cause impairment, and due chronic hypoperfusion induced by unilateral common carotid artery occlusion (CCAO) exacerbated Tie2hsEH mice. Behavioral performance was assessed the open field,...
OBJECTIVE: We describe the case of a temporomandibular joint cyst eroding into middle fossa, initially causing compression trigeminal nerve and neuropathy, ultimately destruction second division with facial numbness. CLINICAL PRESENTATION: A 50-year-old woman rheumatoid arthritis on prednisone developed right-sided, lancinating pain that became dull in nature maxillary nerve. This change was associated development numbness same distribution. The gradually resolved, but persisted. Imaging...
Implantable pulse generators (IPGs) store energy and deliver electrical impulses for deep brain stimulation (DBS) to treat neurological psychiatric disorders. IPGs have evolved over time meet the demands of expanding clinical indications more nuanced therapeutic approaches.The aim this study was examine workflow first 4-lead IPG DBS in patients with complex disease.The engineering capabilities, use cases, surgical technique are described a cohort 12 epilepsy, essential tremor, Parkinson's...
Cells in the precentral gyrus of human brain directly send signals to periphery generate movement and are topologically organized as a map body. We find that induced electrophysiological changes from implanted depth electrodes extend this 3-dimensionally throughout volume gyrus. Unexpectedly, organization is interrupted by motor association area depths central sulcus at its mid-lateral aspect active during many different types movements both sides
Stereoelectroencephalography (sEEG) has become the predominant method for intracranial seizure localization. When imaging, semiology, and scalp EEG are not in full agreement or definitively localizing, implanted sEEG recordings used to test candidate onset zones (SOZs). Discovered SOZs may then be targeted resection, laser ablation, neurostimulation. If a SOZ is eloquent, resection ablation both contraindicated, so identifying functional representation crucial therapeutic decision making.
The motor thalamus plays a crucial role in the integration and modulation of sensorimotor information projects to primary cortex. While voltage power spectral changes cortex with movement have been well-characterized, corresponding activity thalamus, particularly broadband (sometimes referred as high gamma) power, remains unclear. present study aims characterize during hand movements 15 subjects undergoing awake deep brain stimulation surgery targeting ventral intermediate (VIM) nucleus for...
Abstract Single pulse electrical stimulation experiments produce pulse-evoked potentials used to infer brain connectivity. The choice of recording reference for intracranial electrodes remains non-standardized and can significantly impact data interpretation. When the electrode is affected by or evoked activity, it contaminate recorded at all other influence interpretation findings. We highlight this specific issue in EEG datasets from two subjects separate institutions. present several...
Stereoelectroencephalography (sEEG) is a mesoscale intracranial monitoring method which records from the brain volumetrically with depth electrodes. Implementation of sEEG in BCI has not been well-described across diverse patient cohort.
ABSTRACT Electrocorticographic (ECoG) signals provide high-fidelity representations of sensorimotor cortex activation during contralateral hand movements. Understanding the relationship between independent and coordinated finger movements along with their corresponding ECoG is crucial for precise brain mapping neural prosthetic development. We analyzed subdural from three adult epilepsy patients electrode arrays implanted seizure foci identification. Patients performed a cue-based task...
Motor thalamus plays a crucial role in integrating and modulating sensorimotor information. While voltage power spectral changes motor cortex with movement are well-characterized, corresponding activity the thalamus, particularly broadband change, remains unclear. The present study aims to characterize during hand movements of 15 subjects undergoing awake deep brain stimulation surgery targeting ventral intermediate (Vim) nucleus for disabling tremor. We analyzed subject-specific low...
✓ Cerebral vasospasm following aneurysmal subarachnoid hemorrhage (SAH) is a disease process for which the lack of effective treatments has plagued neurosurgeons decades. Historically, successful treatment after SAH in acute setting was often followed by rapid, uncontrollable deterioration subacute interval. Little known regarding nature and progression this condition until mid-1800s, when first described Gull. Insight into origin natural history cerebral came slowly over next 100 years,...