A5059989712- Glioma Diagnosis and Treatment
- Spine and Intervertebral Disc Pathology
- Meningioma and schwannoma management
- Radiomics and Machine Learning in Medical Imaging
- Advanced MRI Techniques and Applications
- Brain Metastases and Treatment
- Spinal Fractures and Fixation Techniques
- Intracranial Aneurysms: Treatment and Complications
- Medical Imaging Techniques and Applications
- Neurological disorders and treatments
- Pituitary Gland Disorders and Treatments
- MRI in cancer diagnosis
- Multiple Sclerosis Research Studies
- Cancer, Hypoxia, and Metabolism
- Vascular Malformations Diagnosis and Treatment
- Pelvic and Acetabular Injuries
- Cancer Genomics and Diagnostics
- Musculoskeletal pain and rehabilitation
- Anesthesia and Pain Management
- CNS Lymphoma Diagnosis and Treatment
- Advanced Neuroimaging Techniques and Applications
- Cerebrovascular and Carotid Artery Diseases
- Neuroblastoma Research and Treatments
- Spinal Hematomas and Complications
- Peripheral Neuropathies and Disorders
WinnMed
2014-2025
Mayo Clinic in Arizona
2015-2024
Mayo Clinic
2015-2024
Mayo Clinic in Florida
2010-2023
Neurological Surgery
2015-2023
University of Bologna
2022-2023
Boston Scientific (United States)
2022
Jacksonville College
2010-2021
Alliance for Clinical Trials in Oncology
2020
University Radiology
2018-2020
To retrospectively evaluate the complications of diagnostic cerebral catheter angiography in 19,826 consecutive patients.This HIPAA-compliant study had institutional review board approval, with waiver informed consent. Demographic, procedural, and complication data 19 826 patients undergoing at one institution from 1981 through 2003 were reviewed. Neurologic, systemic, local recorded on basis clinical follow-up results after each angiographic examination. Events that occurred within 24 hours...
<h3>SUMMARY:</h3> MR perfusion imaging is becoming an increasingly common means of evaluating a variety cerebral pathologies, including tumors and ischemia. In particular, there has been great interest in the use for both assessing brain tumor grade monitoring recurrence previously treated patients. Of various techniques devised imaging, dynamic susceptibility contrast method employed most widely among clinical practitioners. However, when implementing DSC contemporary radiology practice,...
A recent meeting was held on March 22, 2019, among the FDA, clinical scientists, pharmaceutical and biotech companies, trials cooperative groups, patient advocacy groups to discuss challenges potential solutions for increasing development of therapeutics central nervous system metastases. key issue identified at this need consistent tumor measurement reliable response assessment, including first step standardized image acquisition with an MRI protocol that could be implemented in multicenter...
Spinal cord infarction (SCI) is often disabling, and the diagnosis can be challenging without an inciting event (eg, aortic surgery). Patients with a spontaneous SCI are misdiagnosed as having transverse myelitis. Diagnostic criteria for lacking, hindering clinical care research.To describe characteristics of propose diagnostic criteria.An institution-based search tool was used to identify patients evaluated at Mayo Clinic, Rochester, Minnesota, from January 1997 December 2017 SCI. provided...
Despite the widespread clinical use of dynamic susceptibility contrast (DSC) MRI, DSC-MRI methodology has not been standardized, hindering its utilization for response assessment in multicenter trials. Recently, Standardization Subcommittee Jumpstarting Brain Tumor Drug Development Coalition issued an updated consensus protocol compatible with standardized brain tumor imaging (BTIP) high-grade gliomas that is increasingly used setting and default MRI National Clinical Trials Network. After...
Advanced molecular and pathophysiologic characterization of primary central nervous system lymphoma (PCNSL) has revealed insights into promising targeted therapeutic approaches. Medical imaging plays a fundamental role in PCNSL diagnosis, staging, response assessment. Institutional variation inconsistent clinical trial reporting diminishes the reliability reproducibility In this context, we aimed to: (1) critically review use advanced positron emission tomography (PET) magnetic resonance...
Craniopharyngiomas, primary brain tumors of the pituitary-hypothalamic axis, can cause clinically significant sequelae. Treatment with use surgery, radiation, or both is often associated substantial morbidity related to vision loss, neuroendocrine dysfunction, and memory loss. Genotyping has shown that more than 90% papillary craniopharyngiomas carry
Abstract Measles virus (MV) vaccine strains have shown significant preclinical antitumor activity against glioblastoma (GBM), the most lethal glioma histology. In this first in human trial (NCT00390299), a carcinoembryonic antigen-expressing oncolytic measles derivative (MV-CEA), was administered recurrent GBM patients either at resection cavity (Group A), or, intratumorally on day 1, followed by second dose after tumor 5 B). A total of 22 received study treatment, 9 Group and 13 B. Primary...
Treatment of the tumor and dural margin with surgery sometimes radiation are cornerstones therapy for meningioma. Molecular classifications have provided insights into biology disease; however, response to treatment remains heterogeneous. In this study, we used retrospective data on 2,824 meningiomas, including molecular 1,686 tumors 100 prospective from RTOG-0539 phase 2 trial define biomarkers response. Using propensity score matching, found that gross resection was associated longer...
To compare longitudinally extensive myelitis in neuromyelitis optica spectrum disorders (NMOSD) and spinal cord sarcoidosis (SCS).We identified adult patients evaluated between 1996 2015 with SCS or NMOSD whose first episode was accompanied by a lesion spanning ≥3 vertebral segments. All were positive for aquaporin-4-immunoglobulin G, all cases pathologically confirmed. Clinical characteristics evaluated. Spine magnetic resonance imaging reviewed 2 neuroradiologists.We studied 71 (NMOSD, 37;...
We hypothesized that vertical blockade of VEGF signaling by combining bevacizumab with sorafenib in patients recurrent glioblastoma would result a synergistic therapeutic effect. also investigated whether VEGF, VEGFR2 and hypoxia-inducible factor-1α single-nucleotide polymorphisms (SNP), circulating biomarkers angiogenesis, MRI markers such as apparent diffusion coefficient (ADC) are correlated treatment efficacy and/or toxicity.Patients received (5 mg/kg every 2 weeks) (200 mg twice day,...
BackgroundThe mammalian target of rapamycin (mTOR) functions within the phosphatidylinositol-3 kinase (PI3K)/Akt pathway as a critical modulator cell survival. This clinical trial evaluated combination mTOR inhibitor everolimus with conventional temozolomide (TMZ)-based chemoradiotherapy.
BACKGROUND: Embolization of spinal dural arteriovenous fistulae (SDVAFs) has emerged as an alternative to surgery. However, surgical disconnection is a simple and effective procedure. OBJECTIVE: To review results complications treatment 154 consecutive SDAVFs. METHODS: The records patients with SDAVFs were retrospectively reviewed. RESULTS: There 120 males 34 females (male/female ratio 3.5:1, mean age 63.6 years). located at the thoracic level in 92 lumbar sacral spine levels 45 15 patients,...
To assess whether a nonparticulate steroid (dexamethasone, 10 mg) is less clinically effective than the particulate steroids (triamcinolone, 80 mg; betamethasone, 12 in lumbar transforaminal epidural injections (TFESIs) subjects with radicular pain or without radiculopathy.Retrospective observational study noninferiority analysis of dexamethasone relative to steroids.Single academic radiology management practice.Three thousand six hundred forty-five TFESIs at L4-5, L5-S1, S1 neural foramina,...
Abroad array of conditions can lead to neurological symptoms in chronic lymphocytic leukemia patients and distinguishing between clinically significant involvement the central nervous system by due other etiologies be challenging. Between January 1999 November 2014, 172 (4%) 4174 with followed at our center had a magnetic resonance imaging and/or lumbar puncture evaluate symptoms. After comprehensive evaluation, etiology was: 18 (10% evaluated puncture, 0.4% overall cohort); Richter Syndrome...
There is a critical need for objective and reliable biomarkers of outcome in meningiomas beyond WHO classification. Loss H3K27me3 has been reported as prognostically unfavorable alteration meningiomas. We sought to independently evaluate the reproducibility prognostic value loss by immunohistochemistry (IHC) multicenter study.IHC staining analyses whole slides from 181 across three centers was performed. Staining analyzed dichotomization into retained immunoreactivity, using 3-tiered scoring...
Patients with progressive or recurrent meningiomas have limited systemic therapy options. Focal adhesion kinase (FAK) inhibition has a synthetic lethal relationship
Abstract Cells in the precentral gyrus directly send signals to periphery generate movement and are principally organized as a topological map of body. We find that movement-induced electrophysiological responses from depth electrodes extend this three-dimensionally throughout gyrus. Unexpectedly, organization is interrupted by previously undescribed motor association area depths midlateral aspect central sulcus. This ‘Rolandic association’ (RMA) active during movements different body parts...