A5074644640- Meningioma and schwannoma management
- Glioma Diagnosis and Treatment
- Spinal Fractures and Fixation Techniques
- Neurofibromatosis and Schwannoma Cases
- Head and Neck Surgical Oncology
- Pituitary Gland Disorders and Treatments
- Vascular Malformations Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Delphi Technique in Research
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Neurosurgical Procedures and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- SARS-CoV-2 and COVID-19 Research
- CNS Lymphoma Diagnosis and Treatment
- Cerebrospinal fluid and hydrocephalus
- Spinal Dysraphism and Malformations
- Brain Metastases and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Cerebral Venous Sinus Thrombosis
- Radiomics and Machine Learning in Medical Imaging
- Epilepsy research and treatment
- Meta-analysis and systematic reviews
- Pharmacological Effects and Toxicity Studies
University of Liverpool
2016-2025
Walton Centre
2018-2025
Salford Royal Hospital
2023-2025
University of Manchester
2022-2025
Manchester Academic Health Science Centre
2023-2025
Salford Royal NHS Foundation Trust
2022-2024
Alder Hey Children's NHS Foundation Trust
2024
The Christie NHS Foundation Trust
2024
Aintree University Hospitals NHS Foundation Trust
2024
Liverpool College
2023
Treatment of the tumor and dural margin with surgery sometimes radiation are cornerstones therapy for meningioma. Molecular classifications have provided insights into biology disease; however, response to treatment remains heterogeneous. In this study, we used retrospective data on 2,824 meningiomas, including molecular 1,686 tumors 100 prospective from RTOG-0539 phase 2 trial define biomarkers response. Using propensity score matching, found that gross resection was associated longer...
Abstract Background Asymptomatic meningioma is a common incidental finding with no consensus on the optimal management strategy. We aimed to develop prognostic model guide personalized monitoring of patients. Methods A disease progression was developed in retrospective cohort (2007–2015), defined as: symptom development, meningioma-specific mortality, growth or loss window curability. Secondary endpoints included non-meningioma-specific mortality and intervention. Results Included were 441...
The optimal management of patients with incidental meningiomas remains unclear. aim this study was to characterize the radiologic and neurological outcomes expectant stereotactic radiosurgery (SRS) asymptomatic meningioma patients.Using data from 14 centers across 10 countries, compares SRS active surveillance meningiomas. Local tumor control development new deficits attributable were evaluated in conservatively managed groups.In unmatched cohorts, 727 underwent followed for a mean 57.2...
Epilepsy is a major cause of morbidity and mortality in meningioma patients. The aims this study were to determine which factors predispose patients developing perioperative seizures understand the impact antiepileptic drugs.Patients treated for histologically-confirmed intracranial at authors' institution between 2010 2015 retrospectively examined. Clinical imaging data assessed. Multivariate analysis was performed using binary logistic regression. effect treatment assessed survival...
Cranioplasty is an operation that aims to repair a defect in the skull. Indications commonly include Traumatic Brain Injury (TBI), tumours, and infections. It carries high rate of postoperative morbidity. Due underlying pathology nature patients' Health-related Quality life (QoL) can be severely affected. Patient reported outcomes (PROs) are poorly understood following cranioplasty. To investigate PROs cranioplasty cross-sectional cohort study adults undergoing between 01/03/2010-30/08/2020...
Abstract Introduction Management for elderly patients (> 65yo) with incidental meningiomas remains unclear. This study aims to characterize the functional and tumor outcomes of expectant stereotactic radiosurgery (SRS) management asymptomatic meningioma patients. Methods Using retrospectively collected data from 14 centers, SRS were compared radiographic clinical observation in following propensity score matching. Results Following matching, 114 each cohort. Tumor control was achieved at...
Abstract Background Core Outcome Sets (COS) define the minimum outcomes that should be measured and reported in all clinical trials for a specific health condition or area. The aim was to develop two COS intracranial meningioma used future studies: COSMIC: Intervention effectiveness Observation studies of incidental/untreated meningioma. Methods A study advisory group formed with representation from international stakeholder groups: EORTC BTG, ICOM, EANO, SNO, RANO-PRO, BNOS, SBNS, BIMS,...
Introduction Following endovascular treatment (EVT) or microsurgical (MT) of intracranial aneurysms (IA), radiological follow-up is performed to assess for recurrence and determine the need re-treatment. There a paucity evidence describing long-term results EVT MT IA therefore data inform design protocols are lacking. The overarching aim META study clinically relevant outcomes IA, use this create based clinical these aneurysms.
INTRODUCTION: Glioblastoma is the most common malignant primary brain tumor in adults. Post-operative MRI used to assess extent of resection, monitor treatment response and detect progression. However, compliance with accepted guidelines for follow-up MRI, impact on patient management outcomes unclear. METHODS: Multi-center, international, retrospective observational cohort study patients confirmed WHO grade 4 glioma (Operated August 2018-February 2019) receiving oncological treatment, May...
Abstract The widespread availability and use of brain magnetic resonance imaging computed tomography has led to an increase in the frequency incidental meningioma diagnoses. Most are small, demonstrate indolent behavior during follow-up, do not require intervention. Occasionally, growth causes neurological deficits or seizures prompting surgical radiation treatment. They may cause anxiety patient present a management dilemma for clinician. questions both clinician “will grow symptoms such...
Radiation induced meningioma (RIM) incidence is increasing in line with improved childhood cancer survival. No optimal management strategy consensus exists. This study aimed to delineate growth rates from tumor discovery and correlate clinical outcomes.Retrospective of patients a RIM, managed at specialist tertiary neuroscience center (2007-2019). Tumor volume was measured diagnosis subsequent interval scans. Meningioma rate determined using linear mixed-effects model. Clinical outcomes were...
The optimal management of asymptomatic, presumed WHO grade I meningiomas remains controversial.To define the safety and efficacy stereotactic radiosurgery (SRS) compared with active surveillance for patients asymptomatic parafalcine/parasagittal (PFPS) meningiomas.Data from SRS-treated 14 centers managed conservatively an PFPS meningioma were compared. Local tumor control rate new neurological deficits development evaluated in cohorts.There 173 98 unmatched cohorts. After matching patient...
Meningioma is the most common primary intracranial tumour in adults. The majority are non-malignant, but a proportion behave more aggressively. Incidental/minimally symptomatic meningioma often managed by serial imaging. Symptomatic meningioma, those that threaten neurovascular structures, or demonstrate radiological growth, usually resected as first-line management strategy. For patients poor clinical condition, with inoperable, residual recurrent disease, radiotherapy used adjuvant...
Investigate the effect of age category (1-9 years vs 10-18 years), sex, Gross Motor Function Classification System (GMFCS) level, and presence dystonia on changes in eight function test parameters 24 months after selective dorsal rhizotomy (SDR).Prospective, single-center study all children aged 3-18 with bilateral cerebral palsy spasticity who underwent SDR at a tertiary pediatric neurosurgery center between 2012 2019. A linear mixed effects model was used to assess longitudinal...
Cranioplasty remains an essential procedure following craniectomy but is associated with high morbidity. We investigated factors outcomes first alloplastic cranioplasty.A single-centre, retrospective cohort study of patients undergoing cranioplasty at a tertiary neuroscience centre (01 March 2010-01 September 2021). Patient demographics and craniectomy/cranioplasty details were extracted. Primary outcome was all-cause explantation. Secondary explantation secondary to infection, surgical...
Few studies have evaluated meningioma patients' longer-term health-related quality of life (HRQoL) following diagnosis and treatment, particularly in those with incidental, actively monitored tumours.A single-center, cross-sectional study was completed. Adult patients surgically managed or more than five years follow-up were included. The patient-reported outcome measures RAND SF-36, EORTC QLQ-C30 QLQ-BN20 used to evaluate HRQoL. HRQoL scores compared normative population data. Outcome...
Intracranial meningioma with bone involvement and primary intraosseous is uncommon. There currently no consensus for optimal management. This study aimed to describe the management strategy outcomes a 10-year illustrative cohort, propose an algorithm aid clinicians in selecting cranioplasty material such patients.A single-centre, retrospective cohort (January 2010-August 2021). All adult patients requiring cranial reconstruction due or were included. Baseline patient characteristics,...