A5041048288- Cerebrovascular and Carotid Artery Diseases
- Advanced MRI Techniques and Applications
- Glioma Diagnosis and Treatment
- CNS Lymphoma Diagnosis and Treatment
- MRI in cancer diagnosis
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Acute Ischemic Stroke Management
- Lanthanide and Transition Metal Complexes
- Lymphoma Diagnosis and Treatment
- Advanced Neuroimaging Techniques and Applications
- Cardiovascular Health and Disease Prevention
- Radiomics and Machine Learning in Medical Imaging
- Brain Metastases and Treatment
- Neurological Disease Mechanisms and Treatments
- Long-Term Effects of COVID-19
- Vascular Malformations Diagnosis and Treatment
- Cerebrospinal fluid and hydrocephalus
- Dementia and Cognitive Impairment Research
- Medical Imaging Techniques and Applications
- Peripheral Neuropathies and Disorders
- Multiple Sclerosis Research Studies
- Cardiac Imaging and Diagnostics
- Moyamoya disease diagnosis and treatment
- Cancer, Hypoxia, and Metabolism
San Salvatore Hospital
2025
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2004-2024
Vita-Salute San Raffaele University
2013-2024
San Raffaele University of Rome
2011-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2011-2024
IRCCS Ospedale San Raffaele
1997-2024
University of Milan
1984-2019
Fondazione Istituto Neurologico Nazionale Casimiro Mondino
2019
Philips (Italy)
2011
University Hospital of Geneva
2009
Perfusion MRI: The Five Most Frequently Asked Technical QuestionsMarco Essig1, Mark S. Shiroishi2, Thanh Binh Nguyen3, Marc Saake1, James M. Provenzale4 5, David Enterline4, Nicoletta Anzalone6, Arnd Dörfler1, Àlex Rovira7, Max Wintermark8 and Meng Law2Audio Available | Share
Advanced molecular and pathophysiologic characterization of primary central nervous system lymphoma (PCNSL) has revealed insights into promising targeted therapeutic approaches. Medical imaging plays a fundamental role in PCNSL diagnosis, staging, response assessment. Institutional variation inconsistent clinical trial reporting diminishes the reliability reproducibility In this context, we aimed to: (1) critically review use advanced positron emission tomography (PET) magnetic resonance...
Among dementia-like diseases, Alzheimer disease (AD) and vascular dementia (VD) are two of the most frequent. AD VD may share multiple neurological symptoms that lead to controversial diagnoses when using conventional clinical MRI criteria. Therefore, other approaches needed overcome this issue. Machine learning (ML) combined with magnetic resonance imaging (MRI) has been shown improve diagnostic accuracy several neurodegenerative including dementia. To end, in study, we investigated, first,...
Reliable biomarkers are needed to avoid diagnostic delay and its devastating effects in patients with primary central nervous system (CNS) lymphoma (PCNSL). We analysed the discriminating sensitivity specificity of myeloid differentiation response (88) (MYD88) L265P mutation (mut-MYD88) interleukin-10 (IL-10) cerebrospinal fluid (CSF) both newly diagnosed (n = 36) relapsed 27) PCNSL 162 controls (118 CNS disorders 44 extra-CNS lymphomas). The concordance MYD88 mutational status between...
PURPOSE: To compare three-dimensional (3D) time-of-flight (TOF) MR angiography, contrast–enhanced digital subtraction angiography (DSA), and rotational for depiction of stenosis. MATERIALS AND METHODS: The study had Ethics Committee approval, each patient gave written informed consent. Forty-nine patients (18 women, mean age, 67.2 years ± 9.1 [± standard deviation], 31 men, 63.1 8.0) with symptomatic stenosis internal carotid artery (ICA) diagnosed at duplex ultrasonography underwent...
Purpose To evaluate the feasibility of a standardized protocol for acquisition and analysis dynamic contrast material–enhanced (DCE) susceptibility (DSC) magnetic resonance (MR) imaging in multicenter clinical setting to verify its accuracy predicting glioma grade according new World Health Organization 2016 classification. Materials Methods The local research ethics committees all centers approved study, informed consent was obtained from patients. One hundred patients with were...
Alzheimer disease (AD) and vascular dementia (VaD) together represent the majority of cases. Since their neuropsychological profiles often overlap white matter lesions are observed in elderly subjects including AD, differentiating between VaD AD can be difficult. Characterization these different forms would benefit by identification quantitative imaging biomarkers specifically sensitive to or VaD. Parameters microstructural abnormalities derived from diffusion tensor (DTI) have been reported...
Purpose: To prospectively compare gadobenate dimeglumine with gadopentetate (0.1 mmol per kilogram body weight) for enhanced magnetic resonance (MR) imaging of central nervous system (CNS) lesions. Materials and Methods: This study was HIPAA-compliant at U.S. centers conducted all according to the Good Clinical Practice standard. Institutional review board regulatory approval were granted; written informed consent obtained. Seventy-nine men 78 women (mean age, 50.5 years ± 14.4 [standard...
Abstract Background Combining MRI techniques with machine learning methodology is rapidly gaining attention as a promising method for staging of brain gliomas. This study assesses the diagnostic value such framework applied to dynamic susceptibility contrast (DSC)-MRI in classifying treatment-naïve gliomas from multi-center patients into WHO grades II-IV and across their isocitrate dehydrogenase (IDH) mutation status. Methods Three hundred thirty-three 6 tertiary centres, diagnosed...
Primary Central Nervous System Lymphoma (PCNSL) is an aggressive neoplasm with a poor prognosis. Although therapeutic progresses have significantly improved Overall Survival (OS), number of patients do not respond to HD-MTX-based chemotherapy (15-25%) or experience relapse (25-50%) after initial response. The reasons underlying this response therapy are unknown. Thus, there urgent need develop predictive models for PCNSL. In study, we investigated whether radiomics features can improve...
Abstract Dengue is the most common arboviral disease globally. It caused by four distinct but closely related viruses (DENV-1, -2, -3, and − 4) transmitted through bites of infected Aedes species mosquito vectors. In last 50 years, incidence has increased 30-fold with increasing geographic expansion to new countries. Here we report important autochthonous epidemic in Italy ever recorded a total 86 confirmed cases occurring September 2024 Fano. They were DENV-2. 61 fever, 21 warning signs no...
The appearance of new clinical manifestations (for example subcutaneous or skin abscesses) during anti-tuberculosis treatment is generally indicative therapeutic failure. cause failure may be the presence a drug-resistant Mycobacterium infection to achieve sufficient concentration drugs in bloodstream. Here we report case 25-year-old man suffering from tuberculosis with lymph nodes and pulmonary involvement an atypical response specific therapy. Two weeks after starting 4-drug antitubercular...
<b>BACKGROUND AND PURPOSE:</b> Our aim was to compare contrast-enhanced MR angiography (CE-MRA) and 3D time-of-flight (TOF) MRA at 3T for follow-up of coiled cerebral aneurysms. <b>MATERIALS METHODS:</b> Fifty-two patients treated with Guglielmi detachable coils 54 aneurysms were evaluated MRA. TOF (TR/TE = 23/3.5; SENSE factor 2.5) CE-MRA by using a ultrafast gradient-echo sequence 5.9/1.8; 3) enhanced 0.1-mmol/kg gadobenate dimeglumine performed in the same session. Source images, maximum...