A5077856001- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Synthesis and biological activity
- Multicomponent Synthesis of Heterocycles
- Neuroblastoma Research and Treatments
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Synthesis and Biological Evaluation
- Synthesis of Organic Compounds
- MicroRNA in disease regulation
- Chemical Synthesis and Reactions
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Photochemistry and Electron Transfer Studies
- Luminescence and Fluorescent Materials
- Phenothiazines and Benzothiazines Synthesis and Activities
- Prostate Cancer Treatment and Research
- Photochromic and Fluorescence Chemistry
- Bone Tumor Diagnosis and Treatments
- Quinazolinone synthesis and applications
- Synthesis and Characterization of Heterocyclic Compounds
Princess Margaret Cancer Centre
2020-2025
University of Toronto
2020-2025
University Health Network
2020-2025
Institute of Chemical Technology
2014-2024
Vignan's Foundation for Science, Technology & Research
2018-2024
George E. Wahlen Department of VA Medical Center
2019-2024
North Maharashtra University
2018-2024
University of Utah
2017-2024
Toronto Public Health
2024
Shri Vile Parle Kelavani Mandal
2024
Abstract Immune-mediated anti-tumoral responses, elicited by oncolytic viruses and augmented with checkpoint inhibition, may be an effective treatment approach for glioblastoma. Here in this multicenter phase 1/2 study we evaluated the combination of intratumoral delivery virus DNX-2401 followed intravenous anti-PD-1 antibody pembrolizumab recurrent glioblastoma, first a dose-escalation then dose-expansion phase, 49 patients. The primary endpoints were overall safety objective response rate....
Treatment of the tumor and dural margin with surgery sometimes radiation are cornerstones therapy for meningioma. Molecular classifications have provided insights into biology disease; however, response to treatment remains heterogeneous. In this study, we used retrospective data on 2,824 meningiomas, including molecular 1,686 tumors 100 prospective from RTOG-0539 phase 2 trial define biomarkers response. Using propensity score matching, found that gross resection was associated longer...
Homozygous deletion of CDKN2A/B was recently incorporated into the World Health Organization classification for grade 3 meningiomas. While this marker is overall rare in meningiomas, its relationship to other CDKN2A alterations on a transcriptomic, epigenomic, and copy number level has not yet been determined. We therefore utilized multidimensional molecular data 1577 meningioma samples from 6 independent cohorts enriched clinically aggressive meningiomas comprehensively interrogate spectrum...
In an endeavor to find a new class of antimicrobial agents, series 2-(1H-benzimidazol-2-yl)-5-(diethylamino)phenol, 2-(1,3-benzoxazol-2-yl)-5-(diethylamino)phenol, 2-(1,3-benzothiazol-2-yl)-5-(diethylamino)phenol and their derivatives were synthesized starting from p-N,N-diethyl amino salicylaldehyde with different substituted o-phenylenediamine or o-aminophenol o-aminothiophenol. The newly compounds characterized by FT-IR, 1H NMR LC–MS analysis. All evaluated for in vitro antibacterial...
Aminopyrazinamides originated from a high throughput screen targeting the Mycobacterium smegmatis (Msm) GyrB ATPase. This series displays chemical tractability, robust structure-activity relationship, and potent antitubercular activity. The crystal structure of Msm in complex with one aminopyrazinamides revealed promising attributes specificity against other broad spectrum pathogens selectivity eukaryotic kinases due to novel interactions at hydrophobic pocket, unlike known inhibitors....
In this topical review article, we attempt to capture recent advances in the development of sustainable hybrid nanocomposite coatings for corrosion inhibition structural metals. Spurred primarily by urgent imperative replacing hexavalent chromium but also driven concerns regarding environmental impact organic solvents, materials criticality considerations, need maintain integrity and function under extreme environments, a renewed impetus towards lightweighting, design new coating concepts...
Cell lines derived from tumor tissues have been used as a valuable system to study gene regulation and cancer development. Comprehensive characterization of the genetic background cell could provide clues on novel genes responsible for carcinogenesis help in choosing particular studies. Here, we carried out whole exome RNA sequencing commonly glioblastoma (GBM) (U87, T98G, LN229, U343, U373 LN18) unearth single nucleotide variations (SNVs), indels, differential expression, fusions editing...
Abstract The widespread emergence of Plasmodium falciparum ( Pf ) strains resistant to frontline agents has fuelled the search for fast-acting with novel mechanism action. Here, we report discovery and optimization antimalarial compounds, triaminopyrimidines (TAPs), which emerged from a phenotypic screen against blood stages . clinical candidate (compound 12 is efficacious in mouse model malaria an ED 99 <30 mg kg −1 displays good vivo safety margins guinea pigs rats. With predicted...
Abstract Background Resolving the differential diagnosis between brain metastases (BM), glioblastomas (GBM), and central nervous system lymphomas (CNSL) is an important dilemma for clinical management of main three intra-axial tumor types. Currently, treatment decisions require invasive diagnostic surgical biopsies that carry risks morbidity. This study aimed to utilize methylomes from cerebrospinal fluid (CSF), a biofluid proximal tumors, reliable non-invasive classification addresses...
This study analyzes the technical performance, costs and life-cycle greenhouse gas (GHG) emissions of production various fuels using air-captured water CO2, concentrated solar energy as source high-temperature process heat. The thermochemical fuel pathway utilizes a ceria-based redox cycle for splitting CO2 to syngas - tailored mixture H2 CO which in turn is further converted liquid hydrocarbon fuels. driven by heat supplemented thermal storage round-the-clock continuous operation. examines...
ESIPT-inspired benzimidazolyl substituted fluorescein dyes were synthesized. PH-sensitivity was determined by the photophysical property measured at a physiological possible pH range. Fluorescence quantum efficiency values calculated independently two different emissions. A rational relationship is defined between fluorescence and HOMO energy.
A novel synthetic approach is developed wherein graphene oxide and oxidized multiwalled carbon nanotubes are used as curing agents to induce cross-linking of an epoxy resin, thereby yielding a nanostructured composite with excellent dispersion the nanomaterials. This method allows for incorporation up 50 wt% nanomaterials within polymeric matrix. The combination covalent bonding π–π interactions ensure dispersibility These nanocomposites offer alternative hazardous high-temperature...
Glioblastomas (GBM) continue to remain one of the most dreaded tumours that are highly infiltrative in nature and easily preclude comprehensive surgical resection. GBMs pose an intricate etiology as they being associated with a plethora genetic epigenetic lesions. Misregulation PI3 kinase pathway is familiar events GBM. While signalling regulated pathways genes have been comprehensively studied, its impact on miRNome yet be explored. The objective this study was elucidate miRNAs miRNA...
Chordomas are rare malignant bone cancers of the skull-base and spine. Patient survival is variable not reliably predicted using clinical factors or molecular features. This study identifies prognostic epigenetic chordoma subtypes that detected noninvasively plasma methylomes.Methylation profiles 68 surgical samples were obtained between 1996 2018 across three international centers along with matched methylomes where available.Consensus clustering identified two stable tissue clusters a...
Abstract Malignant peripheral nerve sheath tumor (MPNST) is a highly aggressive sarcoma, and lethal neurofibromatosis type 1-related malignancy, with little progress made on treatment strategies. Here, we apply multiplatform integrated molecular analysis 108 tumors spanning the spectrum of to identify candidate drivers MPNST that can serve as therapeutic targets. Unsupervised analyses methylome transcriptome profiles two distinct subgroups MPNSTs unique targetable oncogenic programs. We...