A5046414760- HIV/AIDS drug development and treatment
- Oxidative Organic Chemistry Reactions
- Chemical Synthesis and Reactions
- Synthesis and Catalytic Reactions
- Sulfur-Based Synthesis Techniques
- Catalytic C–H Functionalization Methods
- Biochemical and Molecular Research
- Tuberculosis Research and Epidemiology
- Cancer therapeutics and mechanisms
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Drug Transport and Resistance Mechanisms
- Malaria Research and Control
- Organic Chemistry Cycloaddition Reactions
AstraZeneca (India)
2015
AstraZeneca (United Kingdom)
2014
Institute of Chemical Technology
2008-2011
University of Mumbai
2009-2010
Abstract The widespread emergence of Plasmodium falciparum ( Pf ) strains resistant to frontline agents has fuelled the search for fast-acting with novel mechanism action. Here, we report discovery and optimization antimalarial compounds, triaminopyrimidines (TAPs), which emerged from a phenotypic screen against blood stages . clinical candidate (compound 12 is efficacious in mouse model malaria an ED 99 <30 mg kg −1 displays good vivo safety margins guinea pigs rats. With predicted...
Diarylthiazole (DAT), a hit from diversity screening, was found to have potent antimycobacterial activity against Mycobacterium tuberculosis (Mtb). In systematic medicinal chemistry exploration, we demonstrated chemical opportunities optimize the potency and physicochemical properties. The effort led more than 10 compounds with submicromolar MICs desirable activity, in conjunction low molecular weight, made series an attractive lead (antibacterial ligand efficiency (ALE)>0.4). exhibited...
Alpha,alpha-disubstituted acetamides undergo oxidative dehomologation to give one-carbon-shorter ketones when reacted with a hypervalent iodine (lambda(5)) reagent in combination tetraethylammonium bromide (TEAB) various solvents. In further studies, one such of reagent, o-iodoxybenzoic acid, and TEAB has been established as new, mild, efficient, general method for the transformation.
An efficient and convenient method for the synthesis of arylthiols by reaction sulfonyl chlorides with triphenylphosphine in toluene is reported.
Formation of the nitrile was outcome investigation biochemically significant oxidative decarboxylation amino acids using o -iodoxybenzoic acid (IBX) in aqueous ammonia system.
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 200 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”