A5029875111- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Neurofibromatosis and Schwannoma Cases
- MRI in cancer diagnosis
- Brain Metastases and Treatment
- Advanced MRI Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Advanced Neuroimaging Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- Pituitary Gland Disorders and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurogenesis and neuroplasticity mechanisms
- Bone Tumor Diagnosis and Treatments
- Bone and Joint Diseases
- Head and Neck Surgical Oncology
- Radiopharmaceutical Chemistry and Applications
- Ear and Head Tumors
- Traumatic Brain Injury Research
- Nanoplatforms for cancer theranostics
- MicroRNA in disease regulation
- S100 Proteins and Annexins
- Nerve injury and regeneration
- Vascular Malformations Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Cerebrospinal fluid and hydrocephalus
University Children's Hospital Tübingen
2016-2025
Bernstein Center for Computational Neuroscience Tübingen
2016-2025
University of Tübingen
2015-2024
Kreiskliniken Reutlingen
2021-2024
Hertie Institute for Clinical Brain Research
2016-2023
University of Toronto
2023
Center for Neuro-Oncology
2021-2022
Universitätsklinikum Tübingen
2018-2021
Ostalb-Klinikum Aalen
2021
Universitätsklinikum Würzburg
2021
Gliomas are the most frequent intraaxial CNS neoplasms with a heterogeneous molecular background. Recent studies on diffuse gliomas have shown alterations in genes involved chromatin remodelling pathways such as α-thalassemia/mental-retardation-syndrome-X-linked gene (ATRX). Yet, reliability of ATRX predicting isocitrate dehydrogenase (IDH) and H3 histone, family 3A (H3F3A) mutations gliomas, is unclear.We analysed expression status by immunohistochemistry, large series 1064 results...
Treatment options for oncological diseases have been enhanced by the advent of targeted therapies. The point mutation BRAF gene at codon 600 (BRAF V600E) is found in several tumor entities and can be approached with selective inhibitory antibodies. inhibitor vemurafenib has demonstrated clinical efficacy patients V600E-mutant melanoma brain metastases other cancer diseases. Therefore V600E a highly interesting target tumors.This study assesses status 969 intracranial neoplasms using tissue...
PURPOSE Prospective data suggested a superiority of intraoperative MRI (iMRI) over 5-aminolevulinic acid (5-ALA) for achieving complete resections contrast enhancement in glioblastoma surgery. We investigated this hypothesis prospective clinical trial and correlated residual disease volumes with outcome newly diagnosed glioblastoma. METHODS This is controlled multicenter parallel-group two center-specific treatment arms (5-ALA iMRI) blinded evaluation. The primary end point was resection on...
Homozygous deletion of CDKN2A/B was recently incorporated into the World Health Organization classification for grade 3 meningiomas. While this marker is overall rare in meningiomas, its relationship to other CDKN2A alterations on a transcriptomic, epigenomic, and copy number level has not yet been determined. We therefore utilized multidimensional molecular data 1577 meningioma samples from 6 independent cohorts enriched clinically aggressive meningiomas comprehensively interrogate spectrum...
Antiepileptic treatment of brain tumor patients mainly depends on the individual physician's choice rather than well-defined predictive factors. We investigated value defined clinical parameters to formulate a model risk estimations for subpopulations patients.We enclosed 650 > 18 years age who underwent surgery and included number data. Logistic regressions were performed determine effect sizes seizure-related factors develop prognostic scores occurrence preoperative early postoperative...
A loss of the trimethylation lysine 27 histone H3 (H3K27me3) in meningioma has been recently suggested as an adjunct to identify subsets higher risk recurrence. The aim present study was assess prognostic value H3K27 and its potential clinical utility "Tübingen cohort."Patients who underwent resection between October 2003 December 2015 at University Hospital Tübingen were included. Immunohistochemical stainings for H3K27me3 proliferation marker MIB1 assessed correlated with parameters using...
Proton MR spectroscopy (1H-MRS) has been previously used to monitor metabolic changes in areas of diffuse brain injury. We studied metabolism the close vicinity experimental traumatic contusions and remote on contralateral side from 1h 28d post-injury. Changes creatine phosphocreatine (Cr&PCr), N-acetylaspartate (NAA), choline (Cho), inositol (Ino), taurine (Tau), glutamate (Glu), lactate (Lac) were assessed compared neuronal, glial inflammatory histology. In pericontusional zone Cr&PCr,...
The purpose of this study was to correlate intravoxel incoherent motion (IVIM) imaging with classical perfusion‐weighted MRI metrics in human gliomas. Parametric images for slow diffusion coefficient ( D ), fast *), and fractional perfusion‐related volume f ) patients high‐grade gliomas were generated. Maps F p (plasma flow), v (vascular plasma volume), PS (permeability surface–area product), e (extravascular, extracellular E (extraction ratio), k (influx ratio into the interstitium), t c...
Purpose The aim of this study was to translate the T 1 ρ‐based dynamic glucose‐enhanced (DGEρ) experiment from ultrahigh magnetic field strengths a clinical strength 3 T. Although protocol would seem be as simple gadolinium‐enhanced imaging, several obstacles had addressed, including signal‐to‐noise ratio (SNR), robustness contrast, and postprocessing, especially motion correction. Methods Spin‐lock based presaturation 3D gradient‐echo snapshot readout were optimized for with regard...
Abstract Since the introduction of Simpson grading for extent resection in meningiomas 1957, its usefulness modern neurosurgery has been challenged. Especially, updated WHO classification regarding brain invasion and efficacy radiation therapy not taken into account when evaluating prognostic role this era. We analyzed clinical histopathological data 1571 that were surgically resected authors’ institution between July 2003 March 2017. Operative reports reviewed according to grading....
The clinical utility of molecular profiling and targeted therapies for neuro-oncology patients outside trials is not established. We aimed at investigating feasibility therapy in adult with advanced tumors the nervous system within a prospective observational study.molecular tumor board (MTB)@ZPM (NCT03503149) precision medicine study tumors. After inclusion patients, we performed comprehensive profiling, formulated ranked biomarker-guided recommendations based on consensus by MTB, collected...
Experimental human fetal neural progenitor cell (hfNPC) transplantation has proven to be a promising therapeutic approach after traumatic brain injury (TBI). However, the long-term efficacy and safety, which are both highly important for clinical translation of this approach, have thus far not been investigated. This study investigated effect local (L, 1 × 10(5) cells) systemic (S, 5 administration PKH-26-labeled pre-differentiated hfNPCs over period 12 weeks, beginning 24 h severe...
Purpose To examine in vivo metabolic alterations the isocitrate dehydrogenase (IDH) mutated gliomas using magnetic resonance spectroscopy (MRS) at field 9.4T. Materials and Methods Spectra were acquired with a 9.4T whole‐body scanner use of custom‐built head coil (16 channel transmit 31 receive). A modified stimulated echo acquisition mode (STEAM) sequence was used for localization. Eighteen patients brain tumors probable glial origin participated this study. The study performed accordance...
Abstract Preoperative hearing function shows wide variations among patients diagnosed with vestibular schwannoma. Besides the preoperative tumor size there are other factors that influence frequently discussed. A comprehensive analysis of a large cohort schwannomas has potential to describe new insights and management. We analyzed clinical factors, imaging data expression proliferation marker MIB1 as influencing on in retrospective 523 primary sporadic schwannomas. The results audiometry...