Farshad Nassiri
A5007013927- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Pituitary Gland Disorders and Treatments
- Neurofibromatosis and Schwannoma Cases
- Spinal Fractures and Fixation Techniques
- Head and Neck Surgical Oncology
- Radiomics and Machine Learning in Medical Imaging
- Spine and Intervertebral Disc Pathology
- Epigenetics and DNA Methylation
- Brain Metastases and Treatment
- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
- Bone Tumor Diagnosis and Treatments
- Neurosurgical Procedures and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Adrenal and Paraganglionic Tumors
- Sarcoma Diagnosis and Treatment
- Cervical and Thoracic Myelopathy
- Neuroblastoma Research and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Growth Hormone and Insulin-like Growth Factors
- Cerebrospinal fluid and hydrocephalus
- Chromatin Remodeling and Cancer
- RNA modifications and cancer
- Virus-based gene therapy research
University of Toronto
2016-2025
Princess Margaret Cancer Centre
2018-2025
University Health Network
2015-2025
Hospital for Sick Children
2018-2024
SickKids Foundation
2018-2024
University of Utah
2024
Toronto Public Health
2024
Toronto Western Hospital
2016-2023
Systems, Applications & Products in Data Processing (Canada)
2018-2023
McMaster University
2015-2019
Abstract Background Variability in standard-of-care classifications precludes accurate predictions of early tumor recurrence for individual patients with meningioma, limiting the appropriate selection who would benefit from adjuvant radiotherapy to delay recurrence. We aimed develop an individualized prediction model risk combining clinical and molecular factors meningioma. Methods DNA methylation profiles clinically annotated samples across multiple institutions were used a methylome 5-year...
Meningiomas are the most common primary intracranial tumor in adults. Clinical care is currently guided by World Health Organization (WHO) grade assigned to meningiomas, a 3-tiered grading system based on histopathology features, as well extent of surgical resection. behavior, however, often fails conform WHO grade. Additional prognostic information needed optimize patient management.We evaluated whether chromosomal copy-number data improved prediction time-to-recurrence for patients with...
Abstract Immune-mediated anti-tumoral responses, elicited by oncolytic viruses and augmented with checkpoint inhibition, may be an effective treatment approach for glioblastoma. Here in this multicenter phase 1/2 study we evaluated the combination of intratumoral delivery virus DNX-2401 followed intravenous anti-PD-1 antibody pembrolizumab recurrent glioblastoma, first a dose-escalation then dose-expansion phase, 49 patients. The primary endpoints were overall safety objective response rate....
We investigated prognostic models based on clinical, radiologic, and radiomic feature to preoperatively identify meningiomas at risk for poor outcomes.Retrospective review was performed 303 patients who underwent resection of 314 (57% World Health Organization grade I, 35% II, 8% III) two independent institutions, which comprised primary external datasets. For each patient in the dataset, 16 radiologic 172 features were extracted from preoperative magnetic resonance images, grade, local...
There is a critical need for objective and reliable biomarkers of outcome in meningiomas beyond WHO classification. Loss H3K27me3 has been reported as prognostically unfavorable alteration meningiomas. We sought to independently evaluate the reproducibility prognostic value loss by immunohistochemistry (IHC) multicenter study.IHC staining analyses whole slides from 181 across three centers was performed. Staining analyzed dichotomization into retained immunoreactivity, using 3-tiered scoring...
Abstract Background Accurate CNS tumor diagnosis can be challenging, and methylation profiling serve as an adjunct to classify diagnostically difficult cases. Methods An integrated diagnostic approach was employed for a consecutive series of 1258 surgical neuropathology samples obtained primarily in consultation practice over 2-year period. DNA classification using the DKFZ/Heidelberg classifier performed, well unsupervised analyses data. Ancillary testing, where relevant, performed. Results...
Homozygous deletion of CDKN2A/B was recently incorporated into the World Health Organization classification for grade 3 meningiomas. While this marker is overall rare in meningiomas, its relationship to other CDKN2A alterations on a transcriptomic, epigenomic, and copy number level has not yet been determined. We therefore utilized multidimensional molecular data 1577 meningioma samples from 6 independent cohorts enriched clinically aggressive meningiomas comprehensively interrogate spectrum...
Abstract Background Meningiomas exhibit considerable clinical and biological heterogeneity. We previously identified four distinct molecular groups (immunogenic, NF2-wildtype, hypermetabolic, proliferative) that address much of this Despite the utility these groups, stochasticity clustering methods use multi-omics data for discovery limits potential classifying prospective cases. sought to with a dedicated classifier. Methods Using an international cohort 1698 meningiomas, we constructed...
Post-hoc analysis of 606 patients enrolled in the AOSpine CSM-NA or CSM-I prospective, multicenter cohort studies.The aim this study was to determine minimum clinically important difference (MCID) SF-36v2 Physical Component Summary (PCS) and Mental (MCS) scores undergoing surgery for degenerative cervical myelopathy (DCM).There has been a shift toward focus on patient-reported outcomes (PROs) spine surgery. However, numerical PROs lack immediate clinical meaning. The MCID adds dimension...
To evaluate the outcomes of patients with giant pituitary tumours (GPTs) who underwent a purely binasal endoscopic transsphenoidal surgery (BETS) and compare their those achieved through craniotomy microscopic (MTS).Seventy-two consecutive GPTs (greater than 10 cm3 in volume) were treated surgically BETS, craniotomy, or MTS from October 1994 to July 2009 reviewed for clinical outcomes, degree tumor resection, recurrence rates, surgical complications.The BETS group had significantly better...