A5005990736- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Fatty Acid Research and Health
- Eicosanoids and Hypertension Pharmacology
- Neuropeptides and Animal Physiology
- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
- Glaucoma and retinal disorders
- Receptor Mechanisms and Signaling
- Traumatic Brain Injury and Neurovascular Disturbances
- Barrier Structure and Function Studies
- Neurological Disease Mechanisms and Treatments
- Heart Rate Variability and Autonomic Control
- Acute Ischemic Stroke Management
- Immune Response and Inflammation
- Sleep and related disorders
- Sleep and Wakefulness Research
- Retinal and Optic Conditions
- Diet and metabolism studies
- Neuroscience of respiration and sleep
- Adipose Tissue and Metabolism
- Antiplatelet Therapy and Cardiovascular Diseases
- Retinal Imaging and Analysis
- Inflammatory mediators and NSAID effects
- Skin Protection and Aging
Oregon Health & Science University
2019-2025
Gamal Abdel Nasser University of Conakry
2022-2023
Ignace Deen Hospital
2023
Donka Hospital
2021-2022
Institut Gustave Roussy
2016-2017
Centre de recherche en Epidémiologie et Santé des Populations
2016-2017
Dalhousie University
2013
Hôpital du Sacré-Cœur de Montréal
2008-2012
Université de Montréal
2007-2012
New York University Press
2009
Proinflammatory cytokines play a central role in depression-like behaviour and apoptosis the limbic system after myocardial infarction (MI). A PUFA n -3 diet or combination of Lactobacillus helveticus R0052 Bifidobacterium longum R0175 probiotics, when given before ischaemic period, reduce circulating proinflammatory as well system. The present study was designed to determine if same nutritional interventions maintain their beneficial effects started onset reperfusion period attenuate...
Abstract Depression is diagnosed in 15–30% of patients following myocardial infarction (MI) and this may also be observed the rat. We measured effects antidepressant sertraline on behavioural biochemical events MI a rat model. Following surgery, rats sham controls were treated with (10 mg/kg, i.p.) or saline. Subgroups tested for depression 14 days after surgery. Apoptosis was estimated other by measuring caspase-3 activity TUNEL positive cells (3 surgery) limbic structures (amygdale,...
Myocardial infarction (MI) stimulates the release of pro-inflammatory substances that induce apoptosis in limbic system. Pro-inflammatory cytokines are considered as root cause apoptosis, although mechanism is not fully explained and/or understood at this time. In addition, depression may gastrointestinal perturbations maintain elevated levels cytokines. It has been shown some specific probiotic formulations reduce problems induced by stress and pro/anti-inflammatory cytokine ratio....
Traumatic brain injury (TBI) causes transient but robust increases in hippocampal neurogenesis, referred to here as the neurogenic response, which is distinct from baseline or constitutive levels of neurogenesis. The response may reflect a restorative process for cognitive recovery TBI. It unknown whether hippocampus remains capable eliciting another subsequent TBI, and potential loss this endogenous repair mechanism affects repeated To address this, 2-month-old male female mice received...
We have observed that, after myocardial infarction (MI), rats display apoptosis in the limbic system that can be prevented by pentoxifylline (PTX), a proinflammatory cytokine inhibitor. hypothesized reduction of attenuate depressive behaviour occurring post-MI. The present study was, therefore, designed to assess outcome PTX on manifesting MI. Myocardial ischaemia, induced for 40 min male Sprague–Dawley rats, was followed reperfusion (MI groups). Sham groups were subjected same protocol...
Recently, we identified that olive leaf extract (OLE) prevents lead (Pb)-induced abnormalities in behavior and neurotransmitters production chronic Pb exposure rats. The aim of the present study was to provide additional evidence OLE acts as an anti-apoptotic, anti-inflammatory, antioxidant mediator exposed 4-weeks old Wistar rats were or not 250 mg/l for 13-weeks then tap water containing 0.1% 2-weeks. Atomic absorption spectrophotometry showed significantly elevated levels hippocampus...
Abstract Introduction The pathogenesis of vascular cognitive impairment (VCI) is not fully understood. GPR39, an orphan G‐protein coupled receptor, implicated in neurological disorders but its role VCI unknown. Methods We performed GPR39 immunohistochemical analysis post mortem brain samples from mild (MCI) and control subjects. DNA was analyzed for single nucleotide polymorphisms (SNPs), correlated with white matter hyperintensity (WMH) burden on pre magnetic resonance imaging. Results...
Changes in dietary omega-6/3 polyunsaturated fatty acids (PUFA) ratios affect anti- and proinflammatory equilibrium. As reperfused myocardial infarction (MI) is an inflammatory pathology that alters the cell integrity of myocardium but also other tissues, such as hippocampus amygdala, attenuation inflammation could be helpful maintaining after MI. Therefore, we hypothesized a decrease PUFA ratio, without altering diet content total fat, proteins, or carbohydrates, will result reduction...
Vascular cognitive impairment (VCI) is the second most common cause of dementia. There no treatment for VCI, in part due to a lack understanding underlying mechanisms. The G-protein coupled receptor 39 (GPR39) regulated by arachidonic acid (AA)-derived oxylipins that have been implicated VCI. Furthermore, GPR39 increased microglia post mortem human brains with Carriers homozygous SNPs higher burden white matter hyperintensity, an MRI marker We tested hypothesis plays protective role against...
Background: Type 2 diabetes (DM2) exacerbates stroke injury, reduces efficacy of endovascular therapy, and worsens long-term functional outcome. Sex differences exist in incidence, response to poststroke microvascular dysfunction, recovery. In this study, we tested the hypotheses that poor outcome after setting DM2 is linked impaired tissue reperfusion male female mice exhibit different transient middle cerebral artery occlusion (MCAO). Methods: Transient MCAO was induced for 60 minutes...
Soluble epoxide hydrolase (sEH) is abundant in the brain, upregulated type 2 diabetes mellitus (DM2), and possible mediator of ischemic injury via breakdown neuroprotective epoxyeicosatrienoic acids (EETs). Prophylactic, pre-ischemic sEH blockade with 4-[[trans-4-[[(tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]cyclohexyl]oxy]-benzoic acid (tAUCB) reduces stroke-induced infarct normal diabetic mice, larger neuroprotection DM2. The present study tested whether benefit occurs DM2 mice if...
Acute myocardial infarction (MI) is followed, within a few hours, by neuronal loss in the central nervous system (CNS), including limbic system, hypothalamus, and brainstem. Sleep before after MI was investigated first experiment. In parallel experiment, 2 weeks MI, we quantified brainstem cholinergic neurons known to control paradoxical sleep (PS). Data were obtained from 28 adult male Sprague-Dawley rats weighing 350–375 g maintained under 12-12 light-dark cycle experiments on 16 12 rats,...
Abstract Soluble epoxide hydrolase (sEH) is upregulated in microvascular endothelium of human brain with vascular cognitive impairment (VCI). Transgenic endothelial expression sEH mice (Tie2hsEH) induces dysfunction (ED), a pathogenetic mechanism VCI. We sought to determine if upregulation sufficient cause impairment, and due chronic hypoperfusion induced by unilateral common carotid artery occlusion (CCAO) exacerbated Tie2hsEH mice. Behavioral performance was assessed the open field,...
Abstract INTRODUCTION The pathogenesis of vascular cognitive impairment (VCI) is not fully understood. GPR39, an orphan G-protein coupled receptor, implicated in neurological disorders but its role VCI unknown. METHODS We performed GPR39 immunohistochemical analysis postmortem brain samples from mild (MCI) and control subjects. DNA was analyzed for SNPs, correlated with white matter hyperintensity (WMH) burden on premortem MRI. RESULTS expressed aged human dorsolateral prefrontal cortex,...
This study was designed to evaluate the effect of long-term pretreatment with celecoxib, a cyclooxygenase-2 inhibitor, on myocardial infarct size. Celecoxib (3 mg/kg/day i.p; n = 16) or vehicle (DMSO 50%; EtOH 15%; distilled water, administered chronically male Sprague-Dawley rats through ALZET osmotic pumps for 28 days. Under anaesthesia, animals were then subjected left anterior descending coronary artery occlusion 40 minutes, followed by 24-hour reperfusion. The results show that size in...
Incidence rates have increased considerably worldwide for both differentiated thyroid cancer and cutaneous melanoma, two-way associations between these neoplasms been described. Whether melanoma risk factors are associated with remains unknown.Using Cox regression modeling, we prospectively analyzed the relationship self-reported pigmentary traits, baseline residential ultraviolet (UV) exposure, in 86,960 women from E3N cohort, followed-up over 1990-2008 through biennial questionnaires. We...