A5101730067- Anesthesia and Pain Management
- Musculoskeletal pain and rehabilitation
- Palliative Care and End-of-Life Issues
- Patient-Provider Communication in Healthcare
- Receptor Mechanisms and Signaling
- Biochemical Analysis and Sensing Techniques
- Barrier Structure and Function Studies
- Regulation of Appetite and Obesity
- Pain Management and Opioid Use
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Acute Ischemic Stroke Management
- Eicosanoids and Hypertension Pharmacology
- Anesthesia and Sedative Agents
- Anesthesia and Neurotoxicity Research
- Cancer, Hypoxia, and Metabolism
- Neonatal and fetal brain pathology
- Traumatic Brain Injury and Neurovascular Disturbances
- Healthcare Decision-Making and Restraints
- Inflammatory mediators and NSAID effects
Oregon Health & Science University
2020-2022
Abstract Background and Purpose No current treatments target microvascular reperfusion after stroke, which can contribute to poor outcomes even successful clot retrieval. The G protein-coupled receptor GPR39 is expressed in brain peri-capillary pericytes, has been implicated regulation, but its role stroke unknown. We tested the hypothesis that plays a protective part due preservation of perfusion. generated knockout (KO) mice whether gene deletion worsens capillary blood flow exacerbates...
Background: Ischemic stroke is a leading cause of morbidity and mortality. Efficacy current thrombolytic endovascular therapies are not uniform in all patients, depends on age, severity diabetic status. This part attributed to impaired microvascular reperfusion, which limits the benefit from large-vessel recanalization. Microvascular blood flow regulated by number molecules including P450 eicosanoids arachidonic acid-derived lipid signaling whose levels known be altered during stroke. We...